Hepatoprotective and anti-inflammatory activities of Plantago major L.

Türel, İdris; Özbek, Hanefí; Erten, Remzi; Öner, Ahmet Cihat; Cengiz, Nureddin; Yılmaz, Orhan

doi:10.4103/0253-7613.55211

Cited by 52 publications

(11 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 113 In addition, Plantago major exhibited anti-inflammatory activity at 20 and 25 mg/kg as compared to indomethacin and placebo. 114 In another study, the aqueous extract of leaves (1 g/kg) could reduce acetic acid–induced writhing and carrageenan-induced paw edema and pleurisy. 115 …”

Section: Resultsmentioning

confidence: 96%

An Evidence-Based Study on Medicinal Plants for Hemorrhoids in Medieval Persia

Hashempur

Khademi

Rahmanifard

et al. 2017

J Evid Based Complementary Altern Med

View full text Add to dashboard Cite

Hemorrhoids is one of the most common gastrointestinal diseases. There are several therapeutic options associated with some complications. Therefore, researchers look for traditional medicines as a potential resource for introduction of new natural drugs. The current study reports an evidence-based review of herbal remedies for hemorrhoids in traditional Persian medicine. A comprehensive survey about hemorrhoids on the most important manuscripts of traditional Persian medicine was done. Then, scientific data banks were searched for possible related properties of each herb in the conventional medicine. We reported some historical aspects of traditional Persian medicine view on classification, examination, and predisposing factors of hemorrhoids. In addition, we have reported 105 medicinal plants belonging to 51 families. More than half of the reported herbs exhibited anti-inflammatory and analgesic effects. Although lack of human studies regarding the mentioned herbs is noted, positive results from experimental findings can be considered for new drug discovery supported by traditional and medieval experiences.

show abstract

Section: Resultsmentioning

confidence: 96%

An Evidence-Based Study on Medicinal Plants for Hemorrhoids in Medieval Persia

Hashempur

Khademi

Rahmanifard

et al. 2017

J Evid Based Complementary Altern Med

View full text Add to dashboard Cite

show abstract

“…In recent years, hepatic disorders have been the main cause of deaths around the world ( 26 ). In one model of animal study, extract of Plantago major seed, exhibits the hepatoprotective activity by which the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) showed reduction ( 26 , 27 ).…”

Section: Resultsmentioning

confidence: 99%

Plantago major in Traditional Persian Medicine and modern phytotherapy: a narrative review

Najafian¹,

Hamedi²,

Farshchi³

et al. 2018

Electron Physician

View full text Add to dashboard Cite

Plantago major has been used widely since ancient times, to manage a wide range of diseases including constipation, coughs and wounds. The aim of this study is to review the traditional application, botanical characterization, pharmacological activities, phytochemistry effects and toxicity of Plantago major. In this review study, medicinal properties of Plantago major are collected from credible pharmacopeias, textbooks of traditional Persian medicine (TPM) belonging to the 10–18th century AD, such as “The Canon of Medicine”, “Makhzan-Al- Advia” and so on. Moreover, electronic databases including Scopus, Medline and Web of science were explored for this purpose. Plantago major has been prescribed in various forms such as roasted seeds, decoction, syrup, liniment, gargle, rectal enema, vaginal suppository, eye and nasal drop for each illness by TPM scholars. Some of its traditional properties including wound healing, antipyretic, antitussive, anti-infective, anti-hemorrhagic, anti-inflammatory, diuretic, laxative, astringent and hemostatic have been confirmed in recent researches. Phytochemical investigations showed that Plantago major contains volatile compounds, triterpenoids, phenolic acids and flavonoids. Modern pharmacological studies have proven some of the traditional applications of Plantago major. Nevertheless, more investigations are required on this plant, because it has the potential to be used to produce various natural medications.

show abstract

“…The in vivo anti-inflammatory activity of P. major has been well described [ 17 ]. The anti-inflammatory activity of the extracts was determined using lipoxygenase assay.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Property ofPlantago majorLeaf Extract Reduces the Inflammatory Reaction in Experimental Acetaminophen-Induced Liver Injury

Hussan

Mansor

Hassan

et al. 2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Hepatic injury induces inflammatory process and cell necrosis. Plantago major is traditionally used for various diseases. This study aimed to determine the anti-inflammatory property of P. major leaf extracts on inflammatory reaction following acetaminophen (APAP) hepatotoxicity. Thirty male Sprague-Dawley rats were divided into 5 groups, namely, normal control (C), APAP, aqueous (APAP + AQ), methanol (APAP + MT), and ethanol (APAP + ET) extract treated groups. All APAP groups received oral APAP (2 g/kg) at day 0. Then, 1000 mg/kg dose of P. major extracts was given for six days. The levels of liver transaminases were measured at day 1 and day 7 after APAP induction. At day 7, the blood and liver tissue were collected to determine plasma cytokines and tissue 11β-HSD type 1 enzyme. The in vitro anti-inflammatory activities of methanol, ethanol, and aqueous extracts were 26.74 ± 1.6%, 21.69 ± 2.81%, and 12.23 ± 3.15%, respectively. The ALT and AST levels were significantly higher in the APAP groups at day 1 whereas the enzyme levels of all groups showed no significant difference at day 7. The extracts treatment significantly reduced the proinflammatory cytokine levels and significantly increased the 11β-HSD type 1 enzyme activity (p < 0.05). In conclusion, the P. major extracts attenuate the inflammatory reaction following APAP-induced liver injury.

show abstract

Hepatoprotective and anti-inflammatory activities of Plantago major L.

Cited by 52 publications

References 22 publications

An Evidence-Based Study on Medicinal Plants for Hemorrhoids in Medieval Persia

An Evidence-Based Study on Medicinal Plants for Hemorrhoids in Medieval Persia

Plantago major in Traditional Persian Medicine and modern phytotherapy: a narrative review

Anti-Inflammatory Property ofPlantago majorLeaf Extract Reduces the Inflammatory Reaction in Experimental Acetaminophen-Induced Liver Injury

Contact Info

Product

Resources

About