Hepatoprotective and antioxidant activity of standardized herbal extracts

Hiraganahalli, Bhaskarmurthy Deepak; Chinampudur, Velusami Chandrasekaran; Dethe, Shekhar; Mundkinajeddu, Deepak; Pandre, Manoj Kumar; Balachandran, Jaya; Agarwal, Amit

doi:10.4103/0973-1296.96553

Cited by 74 publications

(25 citation statements)

References 35 publications

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“…Dhatri is Rasayana and Yakrututtejaka and has been proved as antioxidant, immunomodulator, and hepatoprotective. [ 24 ] Yashtimadhu ( Glycyrrhiza glabra L.) is Rasayana and active bio-availability enhancer. [ 25 ] Amruta ( Tinospora cordifolia [Willd.]…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of Punarnava Mandura and Dhatri Lauha in the management of Garbhini Pandu (anemia in pregnancy)

Khandelwal

Donga

Dei

2015

AYU

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Introduction:India is one of the countries with high prevalence of anemia during pregnancy. Anemia in pregnancy is multifactorial. Iron deficiency anemia is the most common conditions in a pregnant woman. As per ayurvedic classics, this condition occurs due to improper Rasa Dhatu in mother and continuously increasing fetal demands and is considered as Rasa Pradoshajavikara. A large number of Lauha preparations have been used widely for centuries to cure Anemia.Aim:To evaluate efficacy of Punarnava Mandura and Dhatri Lauha on Garbhini Pandu.Materials and Methods:A total 24 pregnant women with symptoms of Garbhini Pandu were randomly divided into two groups (A and B). In Group A (n = 15) Punarnava Mandura, two tablets (each of 500 mg) thrice a day with one cup (100 ml) of buttermilk and in Group B (n = 9) Dhatri Lauha, two tablets (each of 500 mg) thrice a day with luke warm water were administered for 90 days. The assessment was done with subjective parameters such as pallor, general weakness, dyspnea, etc., and objective parameters such as hematological parameters. Results were statistically analyzed using Student's t-test.Results:The results revealed that overall clinical improvement was better in Group A when compared to Group B. Hemoglobin was increased in patients of Group A, which was statistically significant. No adverse drug reaction was observed during the treatment period.Conclusion:Punarnava Mandura is more effective on Garbhini Pandu in comparison to Dhatri Lauha.

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Section: Discussionmentioning

confidence: 99%

Clinical efficacy of Punarnava Mandura and Dhatri Lauha in the management of Garbhini Pandu (anemia in pregnancy)

Khandelwal

Donga

Dei

2015

AYU

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“…However, due to consumption of alcohol, exposure of environmental toxin, over drugs consumption lead the liver in various ailments like hepatitis, cirrhosis, etc. [ 5 6 ] Carbon tetrachloride (CCl 4 ) is a widely used hepatotoxic chemical to induce the liver and tissue damage in laboratory animal experiment. [ 7 8 ] The main principle of CCl 4 − induced liver damage is the lipid peroxidation and decreases the antioxidant enzyme system by producing free radicals.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant and hepatoprotective activity of fruit rind extract of Garcinia dulcis (Roxburgh) Kurz

Gogoi¹,

Gogoi²,

Neog³

et al. 2017

Phcog Res

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Background:Garcinia spp. belongs to the family Clusiaceae has been traditionally used for the treatment of many ailments including the liver damage. Garcinia dulcis found in North Eastern region of Assam; India can be a potential candidature to combat different ailments. Objective: The present work has been designed in such a way to appraisal the antioxidant and hepatoprotective activity of fruit rind extract of this plant.Materials and Methods:The antioxidant activity was investigated through the various in vitro models, namely, 2,2-diphenyl-1-picrylhydrazine, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid, nitrite oxide. Phytochemical investigation for total phenolic and flavonoids contents were carried out by standard protocol. For the evaluation of hepatoprotective activity, albino Wistar rats were divided into five groups, five animals per group and activity was determined by measuring the contents of liver function marker enzymes such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), and biochemical parameter, that is, Bilirubin and total protein. Histopathology observation of liver sections was conducted.Results:Phytochemical investigation revealed the presence of both phenolic and flavonoid groups in the extract in a significant amount. Antioxidant activity of the plant extract was observed in all models and percentage of inhibition was dose-dependent. Intoxicated with carbon tetrachloride, elevated the liver function enzymes, bilirubin, and suppressed the production of total protein. Pretreatment with the extract decreased the SGOT, SGPT, ALP, and bilirubin level significantly and increased the production level of total protein in a dose-dependent manner. The histopathological observation supported the hepatoprotective potentiality of the extract.Conclusion:The results indicate that fruit rind part of G. dulcis is nontoxic and the plant can utilize as an antioxidant source. The plant has a protective agent for liver damages and other diseases caused by free radicals.SUMMARY In vitro antioxidant and in vivo hepatoprotective activity was evaluatedMethanolic extract was subjected to quantify the both phenolic and flavonoid contents. The extract showed the significant amount of both phenolic and flavonoids contents. The extract showed the free radical scavenging activity in 2,2-diphenyl-1-picrylhydrazine, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid and nitrite oxide modelsThe extract was administrated against the carbon tetrachloride intoxicated animal models to evaluate the hepatoprotective activity by determining the level of liver marker enzymes such as serum glutamate pyruvate transaminase, SGOT, alkaline phosphatase and biochemical parameter such as protein and bilirubin. Pretreatment with the extract reversed the elevated level of the enzymes and increased the protein level in a dose-dependent mannerThe histopathological observations of the liver sections supported the hepatoprotective activity of the ex...

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“…These free radicals begin peroxidation of membrane polyunsaturated fatty acids and covalently bind microsomal lipids and proteins producing lipid peroxides leading to cellular disorders and pathological alterations. [ 9 10 ]…”

Section: Introductionmentioning

confidence: 99%

Toxicological and biochemical studies on Schinus terebinthifolius concerning its curative and hepatoprotective effects against carbon tetrachloride-induced liver injury

2015

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Background:Recently, many efforts have been made to discover new products of natural origin which can limit the xenobiotic-induced hepatic injury. Carbon tetrachloride (CCl4) is a highly toxic chemical that is widely used to study hepatotoxicity in animal models.Objective:The present study was conducted to investigate the curative and protective effects of Schinus terbenthifolius ethanolic extract against CCl4 -induced acute hepatotoxicity in rats.Materials and Methods:S. terbenthifolius extract was orally administered in a dose of 350 mg dried extract/kg b.wt. before and after intoxication with CCl4 for curative and protective experiments, respectively. A group of hepatotoxicity indicative enzymes, oxidant-antioxidant capacity, DNA oxidation, and apoptosis markers were measured.Results:CCl4 increased liver enzyme leakage, oxidative stress, hepatic apoptosis, DNA oxidation, and inflammatory markers. Administration of S. terebinthifolius, either before or after CCl4 intoxication, significantly decreased elevated serum liver enzymes and reinstated the antioxidant capacity. Interestingly, S. terebinthifolius extract inhibited hepatocyte apoptosis as revealed by approximately 20 times down-regulation in caspase-3 expression when compared to CCl4 untreated group. On the other hand, there was neither protective nor curative effect of S. terebinthifolius against DNA damage caused by CCl4.Conclusion:The present study suggests that S. terebinthifolius extract could be a substantially promising hepatoprotective agent against CCl4 toxic effects and may be against other hepatotoxic chemical or drugs.

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Hepatoprotective and antioxidant activity of standardized herbal extracts

Cited by 74 publications

References 35 publications

Clinical efficacy of Punarnava Mandura and Dhatri Lauha in the management of Garbhini Pandu (anemia in pregnancy)

Clinical efficacy of Punarnava Mandura and Dhatri Lauha in the management of Garbhini Pandu (anemia in pregnancy)

Evaluation of antioxidant and hepatoprotective activity of fruit rind extract of Garcinia dulcis (Roxburgh) Kurz

Toxicological and biochemical studies on Schinus terebinthifolius concerning its curative and hepatoprotective effects against carbon tetrachloride-induced liver injury

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