Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice

Rasool, Mahaboobkhan; Sabina, Evan Prince; Ramya, S.; Preety, Pranatharthiharan; Patel, Smita S.; Mandal, Niharika; Mishra, Punya P.; Samuel, Jaisy

doi:10.1211/jpp.62.05.0012

Cited by 150 publications

(91 citation statements)

References 32 publications

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“…Thus, this is in agreement with the works of Randle et al (2008) and Rasool et al (2010) who have reported elevations in serum transaminases (ALT and AST) after administration of high doses of paracetamol in Wistar albino rats. Due to the localization of these enzymes (ALT and AST), measurement of its activities in serum will give an indication of the status of the liver in disease conditions.…”

Section: Resultssupporting

confidence: 93%

Therapeutic effect of an alkaloid-rich fraction of Abrus precatorius seed methanol extract on paracetamol-induced liver damage in rats

Young¹,

Joshua²,

Nwodo³

et al. 2017

Afr. J. Biochem. Res.

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The therapeutic effect of an alkaloid-rich fraction of the chloroform-methanol extract of Abrus precatorius seeds on paracetamol-induced hepatotoxicity in rats was investigated in this study. The extract was fractionated in a 17.5 × 2.5 cm Sephadex G15 swollen, packed and eluted with water. The fractions were spotted on F 2.54 pre-coated thin layer chromatography (TLC) plates and sprayed with Drangendorff's reagent. The fractions that turned purple indicating the presence of alkaloids were pulled together and used in the study. Hepatotoxicity was induced using per oral 2500 mg/kg b.w. of paracetamol. Treatment with the fraction caused a dose-dependent significant decrease (p ˂ 0.05) in the activity of serum liver marker enzymes [alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT), bilirubin levels, serum urea, creatinine and Malondialdehyde (MDA)] concentrations when compared with the positive control, while there was a significant increase (p ˂ 0.05) in the superoxide dismutase (SOD) activity of the treated rats when compared with the positive control. The haematological parameters of the rats treated with fraction I showed significant increases (p˂0.05) in the packed cell volume (PCV) levels, haemoglobin (Hb) concentration and red blood cell (RBC) count compared to the positive control. From these findings, the alkaloid-rich fraction had a therapeutic effect on the paracetamol-intoxicated rats but the standard drug used was more potent.

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Section: Resultssupporting

confidence: 93%

Therapeutic effect of an alkaloid-rich fraction of Abrus precatorius seed methanol extract on paracetamol-induced liver damage in rats

Young¹,

Joshua²,

Nwodo³

et al. 2017

Afr. J. Biochem. Res.

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show abstract

“…The marked release of transaminases into the circulation is indicative of severe damage to hepatic tissue membranes during paracetamol intoxication [36]. This was consistent with the results of previous investigators who studied the effect of chronic paracetamol ingestion on liver damage [37].…”

Section: Discussionsupporting

confidence: 88%

Protective Effect of Curcumin versus N-acetylcystein on Acetaminophen Induced Hepatotoxicity in Adult Albino Rats

AB¹,

HE²

2015

J Cytol Histol

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Curcumin exerted hepatoprotective influences on various animal models of liver injury such as carbon tetrachloride, endotoxin and thioacetamide. This Study aimed to investigate the protective effects of curcumin as compared to N-acetylcysteine in the rat model of acetaminophen induced hepatotoxicity. 55 albino rats were divided into four groups: group (control group). Group II received acetaminophen. Group III received both acetaminophen and N-acetylcysteine and Group IV received both acetaminophen and curcumin. At the end of the experiment, liver specimens were processed for histological study by light microscope and stained immunohistochemically for detection of apoptosis in hepatic cells by using anti p53 and the oxidative damage by anti-inducible nitric oxide synthase (anti iNOS). Serum levels of liver injury markers were assessed as well as the levels of malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) activity were determined in all dissected tissues. Histological examination of liver sections of acetaminophen treated group revealed degeneration, cytoplasmic vacuolation and hydropic necrosis of hepatocytes. The central and the portal veins were dilated and congested and invading infiltrative inflammatory cells were appeared in association with significant increase in p53 and iNOS positive cells. Significant rise in serum levels of liver injury markers and MDA in liver tissues were recorded. However, levels of GSH and SOD were significantly decreased. Both curcumin and N-acetylcysteine resolved most of these morphological, immunohistochemical and biochemical alterations. Curcumin has protective effect similar to N-acetylcysteine against liver damage induced by acetaminophen in rats by reducing oxidative stress and apoptosis.

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“…There are several reports of this beneficial phytochemical for its potential antioxidant activity studied in animal models (2)(3)(4)(5)(6)(7). Other biological activities of GA studied in animal models are anticancer (1), antihyperglycemic (5), hepatoprotective (6), and antiviral (7) activity.…”

Section: Introductionmentioning

confidence: 99%

The Gallic Acid–Phospholipid Complex Improved the Antioxidant Potential of Gallic Acid by Enhancing Its Bioavailability

et al. 2013

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Abstract. Gallic acid (GA) is well known for its antioxidant and hepatoprotective activity, though its effectiveness is restricted due to rapid metabolism and elimination. To overcome these problems, gallic acid-phospholipid complex was prepared and the effect of phospholipid complexation was investigated on carbon tetrachloride (CCl 4 )-induced oxidative damage in rat liver. The complex significantly reduced the hepatic marker enzymes in rat serum and restored the antioxidant enzyme levels with respect to CCl 4 -induced group (P<0.05 and P<0.01). Also, the complex improved the pharmacokinetics of GA by increasing the relative bioavailability and elimination half-life. The study therefore suggests that phospholipid complexation has enhanced the therapeutic efficacy of GA which may be due to its improved absorption and increased bioavailability in rat serum.

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Hepatoprotective and antioxidant effects of gallic acid in paracetamol-induced liver damage in mice

Abstract: The results clearly demonstrate that gallic acid possesses promising hepatoprotective effects.

Cited by 150 publications

References 32 publications

Therapeutic effect of an alkaloid-rich fraction of Abrus precatorius seed methanol extract on paracetamol-induced liver damage in rats

Therapeutic effect of an alkaloid-rich fraction of Abrus precatorius seed methanol extract on paracetamol-induced liver damage in rats

Protective Effect of Curcumin versus N-acetylcystein on Acetaminophen Induced Hepatotoxicity in Adult Albino Rats

The Gallic Acid–Phospholipid Complex Improved the Antioxidant Potential of Gallic Acid by Enhancing Its Bioavailability

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