Hepatoprotective and antioxidant effects of &lt;i&gt;Cymbopogon citratus&lt;/i&gt; Stapf (Lemon grass) extract in paracetamolinduced hepatotoxicity in rats

Saenthaweesuk, Suphaket; Munkong, Narongsuk; Parklak, Wason; Thaeomor, Atcharaporn; Chaisakul, Janeyuth; Somparn, Nuntiya

doi:10.4314/tjpr.v16i1.13

Cited by 14 publications

(10 citation statements)

References 23 publications

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“…Hence our observation indicates NAC treatment, significantly reduces serum MDA levels as shown in previous reports. 34,35 Moreover, serum TAC levels significantly increased, which was likewise consistent with earlier observation. 36 Oxidative stress and inflammatory cascade response are related.…”

Section: Discussionsupporting

confidence: 88%

The Potential Effect of Silymarin Against Paracetamol-Induced Hepatotoxicity in Male Albino Rats

Abed¹,

Khalaf²,

Alnori³

2022

Pharmacogn J.

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Background: Being the main metabolic organ, liver stays in touch with toxicity of introduced materials including, drugs. Protection is priceless to avoid complication of liver toxicity. Objectives: This research aimed to assess the protective impact of silymarin (SIL) on hepatotoxicity based on acute paracetamol (APAP) intoxication in rats in comparison with N-acetylcysteine (NAC). Methods: To do so serum was collected and the liver was analyzed for histological findings on rat model-paracetamol toxicity whether alone or in combination with SIL or NAC. The scenario was based on either preconditioning with SIL/NAC before induction of toxicity or afterwards. Serum liver function tests, pro-oxidant/antioxidant status, and proinflammatory markers were detected alongside liver histological study. Results: The results showed that liver function indices, oxidative state, and pro-inflammatory parameters were significantly changed, and histopathological alterations were detected in the liver of the intoxicated group. These modifications were inverted in groups treated with either SIL or NAC. The results of the current study suggested that SIL might be employed as a hepatoprotective drug against liver damage induced by APAP because of its ability to reduce lipid peroxidation, improve antioxidant defense status, and have anti-inflammatory effects. Conclusion: These results are equivalent to NAC therapy which is a standard drug against APAPrelated hepatotoxicity.

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Section: Discussionsupporting

confidence: 88%

The Potential Effect of Silymarin Against Paracetamol-Induced Hepatotoxicity in Male Albino Rats

Abed¹,

Khalaf²,

Alnori³

2022

Pharmacogn J.

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“…The pretreatment with citral prevented hepatic alterations caused by APAP acute toxicity, preventing the increase of hepatic injury markers (ALT, AST, ALP, and γ GT), MPO activity, and NO concentration in hepatic tissues. Some studies have shown the hepatoprotective effect of lemongrass on hepatotoxicity in experimental model in rats or mice [ 11 , 40 , 41 ] and according to our results, we suggest that this improvement in liver damage by pretreatment with lemongrass essential oil may be associated with citral content, since citral is the major constituent of C. citratus essential oil.…”

Section: Discussionsupporting

confidence: 81%

Hepatoprotective Effect of Citral on Acetaminophen‐Induced Liver Toxicity in Mice

Uchida

Silva-Filho

Cardia

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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High doses of acetaminophen (APAP) lead to acute liver damage. In this study, we evaluated the effects of citral in a murine model of hepatotoxicity induced by APAP. The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) were determined to evaluate the hepatoprotective effects of citral. The livers were used to determine myeloperoxidase (MPO) activity and nitric oxide (NO) production and in histological analysis. The effect of citral on leukocyte migration and antioxidant activity was evaluated in vitro. Citral pretreatment decreased significantly the levels of ALT, AST, ALP, and γGT, MPO activity, and NO production. The histopathological analysis showed an improvement of hepatic lesions in mice after citral pretreatment. Citral inhibited neutrophil migration and exhibited antioxidant activity. Our results suggest that citral protects the liver against liver toxicity induced by APAP.

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“…The potential effect of lemongrass (Cymbopogon Citratus)related to high probability of tannins and flavonoids [Morgado et al, 2015]. Studies showed lemongrass (Cymbopogon Citratus) extracts containing antioxidants such as phenolic compounds and tannins that reduce the levels of lipid peroxide and prevent from the destructive effects, radical scavenging activity, regulatory action on suppressing oxidative stress and stability, permeability of cellular [Saenthaweesuk et al, 2017]. In the same line, the action of lemongrass (Cymbopogon Citratus)related to the its content from phenolic compounds as well as to the fractions of phenolic acids, flavonoids, terpenoids and tannins [Avosehet al, 2015 andRessurreição,2022].…”

Section: Discussionmentioning

confidence: 99%

Lemongrass (Cymbopogon Citratus), and Coenzyme Q10, ameliorates sodium valproate induced reproductive toxicity in rat model

El-Din

2023

Egyptian Journal of Nutrition and Health

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This study was conducted to analyze the impact of lemongrass ( Cymbopogon Citratus ) powder (CP) and aqueous extract (CA) with and without coenzyme Q10 supplementation on reproductive toxicity induced by sodium valproate (SVA) in rat model. Forty-eight male albino rats (210 ± 5g) were divided randomly into 6 groups (n=8 rats).Experimental design; group (1) fed on basal diet as normal control (-ve).Groups(2 -6) received sodium valproate (SVA) orally at dose 500mg/kg/BW daily on the final week of the experimental duration (45 days)to induce reproductive toxicity.Group(2) fed on basal diet with orally SVA at dose 500mg/kg/BW daily (on the final week) as reproductive toxicity control (+ ve),group (3) treated with coenzyme Q10 at dose (150 mg/kg/BW) + (SVA), group (4) treated withle mongrass (Cymbopogon Citratus) powder (CP) at dose (150 gm/kgdiet) + (SVA), group (5) treated with lemongrass (Cymbopogon Citratus) aqueous extract (CA) at dose (150 mg/kg/BW)+ (SVA) and group (6) treated with mixture of(coenzyme Q10+CP+CA) at (50 mg/kg/BW+ 50 gm/kg diet + 50mg/kg/BW, respectively)+(SVA).The antioxidant and phenolic compounds of lemongrass (Cymbopogon Citratus) leaves and its aqueous extract were estimated.Lemongrass(Cymbopogon Citratus) leaves and its aqueous extract contained remarkable amounts of antioxidant compounds.The results showed the groups treated with lemongrass (Cymbopogon Citratus) leaves, aqueous extract and coenzyme Q10 affected the relative weight of (testis and seminal vesicles) positively. Moreover, the parameters determined in this study showed improvement in these levels when compared with reproductive toxicity control. The best results for parameters that were determined in this study, as serum lipid profiles and liver enzymes, testicular antioxidant and lipid peroxidation biomarkers, serum testosterone, (FSH) and (LH) levels in addition,sperm count were shown in groups were treated with (coenzyme Q10+CP+CA) then CP followed by coenzyme Q10 and CA respectively, but most results showed non-significant difference between these groups.The study showed that,lemongrass (Cymbopogon Citratus) alone or combined with coenzyme Q10 has a powerful protection benefits versus SVA-induced reproductive toxicity in rat model, without causing severe oxidative injury to the reproductive organs and hormonal levels that could be attributable to its antioxidants, phenolics and flavonoid contents that related mainly to ameliorate reproductive toxicity induced by sodium valproate in rat model.

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Hepatoprotective and antioxidant effects of <i>Cymbopogon citratus</i> Stapf (Lemon grass) extract in paracetamolinduced hepatotoxicity in rats

Cited by 14 publications

References 23 publications

The Potential Effect of Silymarin Against Paracetamol-Induced Hepatotoxicity in Male Albino Rats

The Potential Effect of Silymarin Against Paracetamol-Induced Hepatotoxicity in Male Albino Rats

Hepatoprotective Effect of Citral on Acetaminophen‐Induced Liver Toxicity in Mice

Lemongrass (Cymbopogon Citratus), and Coenzyme Q10, ameliorates sodium valproate induced reproductive toxicity in rat model

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