Hepatoprotective and antioxidative effects of total phenolics from Laggera pterodonta on chemical-induced injury in primary cultured neonatal rat hepatocytes

Wu, Yicheng; Yang, Leixiang; Wang, Fang; Wu, Xiumei; Zhou, Chang‐Xin; Shi, Shuyun; Mo, Jian‐Xia; Zhao, Yu

doi:10.1016/j.fct.2007.01.011

Cited by 33 publications

(34 citation statements)

References 29 publications

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“…Previous studies have claimed that phenolic compounds have diverse pharmacological activities such as antioxidant, anti-inflammatory, and hepatoprotective activities (Oh et al, 2004;Wu et al, 2007;Ranawat et al, 2010). RPL extract exhibited prominent antioxidant and hepatoprotective potential against CCl 4 -induced damage, in accordance with the description on the pharmacological properties of phenolic compounds in the aforementioned reports.…”

Section: Discussionsupporting

confidence: 64%

“…The CCl 4 -induced experimental damage resembles viral hepatitis histologically due to the formation of free radicals and the occurrence of lipid peroxidation in cellular and organelle membranes (Wu et al, 2007). Toxicity begins with a highly reactive trichloromethyl free radical (·CCl 3 ), which is further converted to trichloromethyl peroxyl radical (CCl 3 OO·), a classical form of reactive oxygen species (ROS), as the initiator of lipid peroxidation (Hsiao et al, 2003;Jain et al, 2008;Ranawat et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

Gao

Sun

Yang

et al. 2011

J. Zhejiang Univ. Sci. B

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Abstract:The hepatoprotective and antioxidant activities of the n-butanol extract of Rubus parvifolius L. (RPL), a widely used medicinal plant, were evaluated. Results demonstrated that RPL extract possessed pronounced hepatoprotective effects against carbon tetrachloride (CCl 4 )-induced hepatic injury in mice, which was at least partially attributed to its strong antioxidant capacity. Treatment with RPL extract markedly attenuated the increases in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels caused by CCl 4 intoxication. It also significantly prevented the decrease in superoxide dismutase (SOD) activity and the increase in malondialdehyde (MDA) content of liver tissue. Meanwhile, histopathological changes of hepatic damage were also remarkably ameliorated. Phytochemical analysis based on high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) revealed the presence of various phenolic compounds, including caffeic acid conjugates, ellagic acid glycosides, and flavonol glycosides, which might be responsible for the hepatoprotective and antioxidant activities of RPL.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

Gao

Sun

Yang

et al. 2011

J. Zhejiang Univ. Sci. B

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“…Herbal extracts are widely used to alleviate chemical-induced liver injury (Su et al, 2013;Wu et al, 2007). Although neotanshinone B, dehydromiltirone, tanshinol A, tanshinone I, dihydrotanshinono I, neotanshinone A, cryptanshinono, tanshinone II A, and salvianolie acid B from S. miltiorrhiza have different structures, the administration of all these components significantly prevented hepatocyte injury and decreased levels of ALB, ALT, AST, ALP, and BIL-T. …”

Section: Discussionmentioning

confidence: 99%

Salvia miltiorrhizacompounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells

Yue

Wang

et al. 2014

Pharmaceutical Biology

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Context: Salvia miltiorrhiza Bunge is a traditional Asian medicine used to treat cerebral and cardiac ischemia. However, the effects of the active compounds of S. miltiorrhiza on liver damage are unclear. Objective: In this study, we tested the effects on acute liver injury of crude S. miltiorrhiza extracts from roots as well as neotanshinone B, dehydromiltirone, tanshinol A, tanshinone I, dihydrotanshinono I, neotanshinone A, cryptanshinono, tanshinone II A, and salvianolie acid B from purified S. miltiorrhiza extracts. Materials and methods: Various compounds or ethanol extract of S. miltiorrhiza (50, 100, and 200 mg/kg, p.o.) were administered to rats for five consecutive days. After acute carbon tetrachloride (CCl 4 )-induced liver injury by treatment of rats with a single dose of CCl 4 (0.75 mL/kg, p.o), rat liver function was tested by measuring serum biochemical parameters. Serum cytokine concentrations were assessed by enzyme-linked immunosorbent assay (ELISA). Expression of p38 and NFkB was evaluated by western blot. Results: All S. miltiorrhiza components showed their effects on liver function from the dose from 50 to 200 mg/kg. At the dose of 200 mg/kg, they reduced serum levels of alkaline phosphatase (ALP) by 34-77%, alanine aminotransferase (ALT) by 30-57%, aspartate aminotransferase (AST) by 43-72%, creatine total bilirubin (BIL-T) by 33-81%, albumin (ALB) by 37-67%, indicating that S. miltiorrhiza extracts protected liver from CCl 4 -induced damage. Moreover, S. miltiorrhiza extracts at 200 mg/kg reduced the increase in the proinflammatory cytokines tumor necrosis factor-a (TNF-a) by 25-82%, interleukin-1 (IL-1) by 42-74% and interleukin-6 (IL-6) by 67-83%, indicating an effect on alleviating liver inflammation. Furthermore, in vitro, S. miltiorrhiza extracts inhibited p38 and NFkB signaling in Kupffer cells. This effect could be a main mechanism by which S. miltiorrhiza protects against acute liver toxicity. Discussion and conclusion: Active compounds of S. miltiorrhiza protected the liver from CCl 4 -induced injury. Protection might have been due to inhibition of p38 and NFkB signaling in Kupffer cells, which subsequently reduced inflammation in the liver.

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“…Bactericidal properties of the volatile oil are reported by Geda in 1995 [16]. Other species of Laggera such as L. pterodonta has been employed in herbal medicine in China as anti inflammatory agent for treatment of hepatitis, arthritis, bronchitis and nephritis [17][18]. However, no significant work has been reported on chemical composition and bioactivity related studies of the species found in Pakistan.…”

Section: Introductionmentioning

confidence: 94%

Chemical composition and biological activities of the essential oil of Laggera aurita Linn (DC.) grown in Pakistan

Shahwar¹,

Ahmad²,

Khan³

et al. 2012

Turk J Bioch

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Hepatoprotective and antioxidative effects of total phenolics from Laggera pterodonta on chemical-induced injury in primary cultured neonatal rat hepatocytes

Cited by 33 publications

References 29 publications

Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

Salvia miltiorrhizacompounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells

Chemical composition and biological activities of the essential oil of Laggera aurita Linn (DC.) grown in Pakistan

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