Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats.

Abstract

-Effect of Tinospora cordifolia extract on modulation of hepatoprotective and immunostimulatory functions in carbon tetrachloride (CCl 4 ) intoxicated mature rats is reported here. Administration of CCl 4 (0.7 ml/kg body weight for 7 days) produces damage in the liver as evident by estimation of enzymes such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transminase (SGPT) and alkaline phosphatase (ALP) as well as serum bilirubin level. CCl 4 administration also causes immunosuppressive effects as indicated by phagocytic capacity, chemotactic migration and cell adhesiveness of rat peritoneal macrophages. However, treatment with T. cordifolia extract (100 mg/kg body weight for 15 days) in CCl 4 intoxicated rats was found to protect the liver, as indicated by enzyme level in serum. A significant reduction in serum levels of SGOT, SGPT, ALP, bilirubin were observed following T. cordifolia treatment during CCl 4 intoxication. Treatment with T. cordifolia extract also deleted the immunosuppressive effect of CCl 4 , since a significant increment in the functional capacities of rat peritoneal macrophages (PMφ) was observed following T. cordifolia treatment. The results of our experiment suggest that treatment by T. cordifolia extract may be the critical remedy for the adverse effect of CCl 4 in liver function as well as immune functions.

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

“…Bilirubin is a product of the chemical breakdown of hemoglobin that increases water solubility in hepatocytes in conjugation with glucuronic acid (33). The present study showed a significant increase in the bilirubin levels of CCl 4 -injected rats, which is in accordance with the findings of previous studies (19,34,35). This hyper-bilirubinemia may be caused by the inhibition of the conjugation reaction and also the release of unconjugated bilirubin from injured and dead hepatocytes (33).…”

“…The present study showed that the dosage of CCl 4 (1 mL/kg) significantly changed the TP, bilirubin, and albumin levels, which is indicative of impaired liver function; these parameters are sensitive indicators of liver damage (19,20). It is generally accepted that liver damage and hepatotoxicity induced by CCl 4 is the best model for screening the protective and antioxidant activity of plant extracts/drugs experimentally (21)(22)(23).…”

Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice

“…Meanwhile, natural health products (NHPs) are generating renewed interest, particularly in the prevention and treatment of several chronic diseases. Herbal drugs are known to posses immunomodulatory properties and generally act by stimulating or suppressing both specific and non-specific immunity [1] .…”

Inhibitory effects of Tinospora cordifolia and Rubia cordifolia Linn. on egg albumin-induced experimental allergic conjunctivitis in rats

“…(RC) is considered to be traditionally useful as an external application in inflammations, ulcers and skin diseases, to relieve the symptoms of pruritis, burning and exudation from skin (Jorapurkar et al, 2003a,b). The antioxidant, anti-inflammatory and immuno-modulatory properties of TC and RC has also been well documented (Tripathi et al, 1997;Kasture et al, 2001;Bishayi et al, 2002;Subramanian et al, 2002). In light of the aforementioned antiinflammatory properties of TC and RC, it is hypothesized that these herbs may be helpful in reducing the antigen-induced conjunctivitis in rats via anti-histaminic activities since inflammatory mediators like histamine is also involved in allergy.…”