Hepatoprotective and proapoptotic effect of Ecballium elaterium on CCl4-induced hepatotoxicity in rats

Naggar, El Moataz Bellah El; Chalupová, Marta; Pražanová, Gabriela; Parák, Tomáš; Švajdlenka, Emil; Žemlička, Milan; Suchý, Pavel

doi:10.1016/j.apjtm.2015.06.012

Cited by 30 publications

(18 citation statements)

References 23 publications

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“…Some studies have described its cytotoxic effects against cancer cells as well as its neuroprotective and hepatoprotective roles [8,11,30]. The core of the EE fruit contains black seeds and a liquid juice.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Ecballium elaterium on brain in a rat model of sepsis-associated encephalopathy

Arslan

Ekinci

Arıcı

et al. 2017

Libyan Journal of Medicine

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Despite recent advances in antibiotic therapy, sepsis remains a major clinical challenge in intensive care units. Here we examined the anti-inflammatory and antioxidant effects of Ecballium elaterium (EE) on brain, and explored its therapeutic potential in an animal model of sepsis-associated encephalopathy (SAE) [induced by cecal ligation and puncture (CLP)].Thirty rats were divided into three groups of 10 each: control, sepsis, and treatment. Rats were subjected to CLP except for the control group, which underwent laparatomy only. The treatment group received 2.5 mg/kg EE while the sepsis group was administered by saline. Twenty-four hours after laparotomy, animals were sacrificied and the brains were removed. Brain homogenates were prepared to assess interleukin 1beta (IL-1β), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), total antioxidant capacity (TAC), and total oxidant status (TOS). Brain tissue sections were stained by hematoxylin and eosin (H&E) to semi-quantitatively examine the histopathologic changes such as neuron degeneration, pericellular/perivascular edema and inflammatory cell infiltration in the cerebral cortex.We found a statistically significant reduction in brain tissue homogenate levels of TNF-α 59.5 ± 8.4/50.2 ± 6.2 (p = 0.007) and TOS 99.3 ± 16.9/82.3 ± 7.8 (p = 0.01) in rats treated with EE; although interleukin 6 levels were increased in the treatment group compared to the sepsis group, this was not statistically significant. Neuronal damage (p = 0.00), pericellular/perivascular edema and inflammatory cell infiltration (p = 0.001) were also significantly lower in the treatment group compared to those in the sepsis group.These data suggest that Ecballium elaterium contains some components that exert protective effects against SAE in part by attenuating accumulation of proinflammatory cytokines, which may be important contributors to its anti-inflammatory effects during sepsis.

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Section: Discussionmentioning

confidence: 99%

“…It has been used in traditional Anatolian medicine for rhinosinusitis treatment due to its topical anti-inflammatory properties. These properties were widely studied by Uslu et al [8,9]. Here, in our study, we wanted to further explore its anti-inflammatory effects and to determine if EE has neuroprotective potential during SAE.…”

Section: Introductionmentioning

confidence: 98%

Effects of Ecballium elaterium on brain in a rat model of sepsis-associated encephalopathy

Arslan

Ekinci

Arıcı

et al. 2017

Libyan Journal of Medicine

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“…Neutrophils gather round the broken hepatocytes, and they induce inflammatory reaction through pro-inflammatory cytokines (TNF-a, IL-1 and IL-6) [33].…”

Section: Discussionmentioning

confidence: 99%

Hematological, antioxidant and protective performance of Usnea longissima on chemical induced hepatotoxicity in experimental animals

Verma¹,

Paswan²,

Raj³

et al. 2017

JCLM

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“…E. elaterium is well known as a medicinal plant in Tunisia, frequently consumed in infusion, mixture of fruit or even in aerosol in cases of fever or flu (Bizid et al, 2014). This plant has been widely used in traditional medicine to treat various health disorders and diseases, including constipation, rheumatism, and jaundice (Toker et al, 2003;Attard et al, 2005;Bohlooli et al, 2012), hepatoprotective and proapoptotic effect (El Naggar et al, 2015). The fresh juice fruit has also been applied into the nostrils for the treatment of sinusitis, chronic jaundice and rheumatism (Jaradat et al, 2012;Sargin et al, 2013;Salhab, 2013).…”

Section: Introductionmentioning

confidence: 99%

Nutritional, phytochemical and antioxidant evaluation and FT-IR analysis of freeze dried extracts of Ecballium elaterium fruit juice from three localities

et al. 2016

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This study was designed to investigate chemical composition, the total phenolic content, flavonoid content, antioxidant activity and to analyze through FT-IR spectroscopy method the freeze-dried extract of Ecballium elaterium fruit from three different localities. The highest level of phenolic and flavonoid contents was recorded for the fruit juice from the Cap-Bon region, with 106.4 ± 0.4 mg GAE/g and 6.5 ± 0.2 mg QE/g, respectively. Antioxidant activity varied in dose-dependent manner with IC 50 values for DPPH scavenging of the freeze-dried fruit juice extracts from Cap-Bon, Kef and Sidi Bouzid were 38.6 ± 0.2, 50.1 ± 0.7, and 50.7 ± 0.2 µg/mL, respectively. The results from the FRAP test showed that the freeze-dried extracts of Cap-Bon exhibited potent activity, followed by those from Kef and Sidi Bouzid. Similar trend were revealed for ABTS•+ test, with the fruit juice extract from Cap-Bon (IC 50 = 0.6 ± 0.0 mg/mL). Furthermore, a good positive correlation was observed between the total phenols and three assays, especially DPPH. The freeze-dried extracts of fruit juice from Cap-Bon showed strong ability to act as antioxidants and can be considered as promising natural source of bioactive compounds. FT-IR analysis of each freeze-dried extract confirmed its richness on polyphenols and biological active functional groups.

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Hepatoprotective and proapoptotic effect of Ecballium elaterium on CCl4-induced hepatotoxicity in rats

Abstract: No reactions confirming the potentially allergic effect on laboratory rats were observed; its hepatoprotective and anti-inflammatory effect was confirmed on a model of acute liver damage.

Cited by 30 publications

References 23 publications

Effects of Ecballium elaterium on brain in a rat model of sepsis-associated encephalopathy

Effects of Ecballium elaterium on brain in a rat model of sepsis-associated encephalopathy

Hematological, antioxidant and protective performance of Usnea longissima on chemical induced hepatotoxicity in experimental animals

Nutritional, phytochemical and antioxidant evaluation and FT-IR analysis of freeze dried extracts of Ecballium elaterium fruit juice from three localities

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