Hepatoprotective Effect of Banana Peel Flour on Histological and Liver Function in Diabetic Rats

Abstract

In diabetes mellitus, non-alcoholic fatty liver disease (NAFLD) is closely linked to hyperglycemia metabolism. This study aimed to find out how a banana peel supplemented diet affected histological and liver function changes in streptozotocin-induced diabetic rats. Vitamins, minerals, dietary fiber, antioxidants, and tryptophan are all contained in banana peel flour (BPF). Serotonin is a neurotransmitter that has been linked to depression and anxiety. This post-test-only control group study was conducted on twenty-five male Wistar rats which were separated into five groups with different treatments. Groups II to V were diabetic rats model groups that consumed standard diet mixed with BPF 0%, 5%, 10%, and 20%, respectively, while group I was a healthy control group fed a standard diet. Hepatic enzyme transaminase (Alanine Aminotransferase-ALT and Aspartate Aminotransferase - AST) and Hematoxylin-Eosin (HE) staining were analyzed with the NAFLD score to examine the liver function and hepatocellular morphology. A change in liver function was observed, as well as a substantial change in the levels of ALT and AST. The NAFLD score with HE staining showed substantial improvements in liver morphology, which was better seen at a 20% BPF dose. The current study supported the hypothesis that BPF had a hepatoprotective effect in diabetic rats, which may be due to the mechanism of controlling the hepatic enzyme transaminase and inducing liver regeneration.

Hepatoprotector Effect of Banana Peel (Musa paradisiaca Sapientum) on Paracetamol Induced Rats

“…Of these two values, p <0.05 indicates that banana peel methanol extract could significantly decrease the SGOT and SGPT levels of rat blood serum. Similar to another results that flour of banana peel has a hepatopeotective effect in diabetic-rats by mechanism of controlling hepatic enzyme transaminase and inducing liver regeneration (Nurrahma et al, 2021).…”

Antioxidative Parameters Improvements on Nutritional Approach: A Study on Hypoxic Multiple Organs of Sprague-Dawley

“…It is known to play a key role in detoxifying and reducing ROS and could stimulate antioxidant metabolism (Gaafar et al 2022). In which tryptophan is the raw material for serotonin synthesis, the antioxidant mechanism might be caused by the presence of phenolic hydroxyl groups from serotonin, which acts as antioxidant compounds in the mechanism of radical scavenging activity with a high content of active antioxidant substances (Nurrahma et al 2021;Meliala et al 2022). We report the generation of ROS as an increase in lipid peroxidation product (MDA) and the decrease of antioxidant enzymes (SOD) in the heart, kidneys, and colon.…”