Hepatoprotective effect of chlorogenic acid against chronic liver injury in inflammatory rats

Chen, Zhenlong; Yang, Yuhui; Mi, Shumei; Fan, Qiang; Sun, Xiaoming; Deng, Baichuan; Wu, Guoyao; Li, Yafei; Zhou, Quancheng; Ruan, Zheng

doi:10.1016/j.jff.2019.103540

Cited by 33 publications

(15 citation statements)

References 55 publications

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“…The activities of AST and ALT in the plasma are usually used clinically as specific indicators of liver injury [30]. Our results are consistent with those of Chen et al [31], who reported that LPS caused significant increases in levels of AST and ALT, as well as in hepatocyte necrosis and the accompanying inflammatory cell infiltration. Our results indicate that broilers treated with combined LPS and CORT showed higher plasma levels of AST and the AST/ALT ratio than following LPS or CORT treatment alone (Figure 3).…”

Section: Discussionsupporting

confidence: 92%

Hepatic Inflammatory Response to Exogenous LPS Challenge is Exacerbated in Broilers with Fatty Liver Disease

Mei

Hao

Xie

et al. 2020

Animals

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This study aimed to examine hepatic function and inflammatory response in broilers with fatty livers, following acute lipopolysaccharide (LPS) challenge. One-day-old Lihua yellow broilers were fed a basal diet. Broilers were divided into four groups: control (CON), corticosterone treatment (CORT), LPS treatment (LPS), and LPS and CORT treatment (LPS&CORT). Results show that CORT induced an increase in plasma and liver triglycerides (TGs), which were accompanied by severe hepatic steatosis. The LPS group showed hepatocyte necrosis with inflammatory cell infiltration. Total liver damage score in the LPS&CORT group was significantly higher than that in the LPS group (p < 0.05). Activity levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were similar in the CON and CORT groups, but higher in the LPS group. Gene expression upregulation of the proinflammatory cytokines (NF-κB, IL-1β, IL-6, IFN-γ, and iNOS) was also noted in the LPS group (p < 0.05). In particular, LPS injection exacerbated the gene expression of these proinflammatory cytokines, even when accompanied by CORT injections (p < 0.05). In summary, our results indicate that broilers suffering from fatty liver disease are more susceptible to the negative effects of LPS, showing inflammatory response activation and more severe damages to the liver.

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Section: Discussionsupporting

confidence: 92%

Hepatic Inflammatory Response to Exogenous LPS Challenge is Exacerbated in Broilers with Fatty Liver Disease

Mei

Hao

Xie

et al. 2020

Animals

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“…The levels of serum/plasma AST and ALT usually serves as speci c indicators of liver injury clinically (Senior, 2012). The results obtained in this study agree with those of Chen et al (2019), who reported that LPS induced in ammatory cell in ltration and caused signi cant increases in levels of AST and ALT, as well as accompanying hepatocyte necrosis. The ndings that a combination of LPS with TRDF signi cantly reduced LPS-induced elevation of AST and ALT is a pointer to the hepato-protective potential of this fraction (TRDF).…”

Section: Discussionsupporting

confidence: 90%

Terpene-rich Fractions of Ficus Mucoso (Welw) Modulate Lipopolysaccharide-induced Inflammatory Mediators and Aberrant Permeability of the Inner Mitochondrial Membrane in Murine Animal Model

Oyebode

Olanlokun

Salami

et al. 2021

Preprint

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Ficus mucoso is traditionally used to treat various infections. This study compared the efficacy of terpene-rich fractions of F. mucoso root bark on LPS-induced inflammation, liver mitochondrial permeability transition (mPT) pore, an index of mitochondrial health, and associated pathological alterations. Terpene-Rich fractions of Dichloromethane (TRDF) and Ethylacetate fractions of F. mucoso (TREF) were obtained according to the method described by Ferguson (1956). A single intraperitoneal injection of 1 mg/kg lipopolysaccharide (LPS) were given to mice to induce systemic inflammation for 72hrs. Evaluation of the effects of the TRDF and TREF on levels of pro-inflammatory mediators (TNF-α, IL-1β, IL-6) and antioxidant indices against LPS-induced hepatic damage were carried out. Mitochondrial swelling was monitored spectrophotometrically as well as mitochondrial ATPase activity and lipid peroxidation. This study reveals that TRDF and TREF possess anti-inflammatory potentials which is related to reduction in levels of pro-inflammatory cytokines, restoration of antioxidant status, reduction in levels of liver marker enzymes as well as associated pathological injury. Furthermore, LPS caused induction of opening of the liver mPT pore which was significantly inhibited by TRDF at 100 and 200 mg/kg bw by 71% and 88% respectively, but only at 100 mg/kg TREF. Furthermore, mitochondrial ATPase activity was inhibited largely by TRDF. The UPLC-ESI-MS analysis revealed the presence of terpenoid derivatives and a few aromatic metabolites in TRDF. The terpene dominance of TRDF metabolites was further justified on the 1H NMR fingerprint.Overall, TRDF is more effective as a cocktail of anti-inflammatory compounds than TREF against LPS-induced acute systemic inflammation.

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“…Phytomolecules like Vitexin and vitexin analogs ( Duan et al, 2020 ), Kaempferol and kaempferol analogs ( Wang M. et al, 2015 ; Wang et al, 2015c ), Quercetin-3-methyl ether ( Tseng et al, 2012 ), Quercetin and quercetin analogs ( Miltonprabu et al, 2017 ), Acacetin analogs ( Cho H.-I. et al, 2014 ), Stigmasterol ( Carter et al, 2007 ), β-Sitosterol ( Abdou et al, 2019 ), Ellagic acid ( Girish and Pradhan, 2012 ), Ferulic acid ( Rukkumani et al, 2004 ), p-Coumaric acid ( Parvizi et al, 2020 ), 2,5-Dihydroxybenzoic acid ( Pujari and Bandawane, 2021 ), Chlorogenic acid ( Chen et al, 2019 ), and β-Carotene ( Manda and Bhatia, 2003 ) which were previously reported from Alternanthera sessilis (L.) R.Br. ex DC., may be the contributory constituents towards the elicited hepatoprotective activity.…”

Section: Introductionmentioning

confidence: 99%

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

et al. 2022

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Ethnopharmacological relevance: The genus Alternanthera (Amaranthaceae) comprises 139 species including 14 species used traditionally for the treatment of various ailments such as hypertension, pain, inflammation, diabetes, cancer, microbial and mental disorders.Aim of the review: To search research gaps through critical assessment of pharmacological activities not performed to validate traditional claims of various species of Alternanthera. This review will aid natural product researchers in identifying Alternanthera species with therapeutic potential for future investigation.Materials and methods: Scattered raw data on ethnopharmacological, morphological, phytochemical, pharmacological, toxicological, and clinical studies of various species of the genus Alternanthera have been compiled utilizing search engines like SciFinder, Google Scholar, PubMed, Science Direct, and Open J-Gate for 100 years up to April 2021.Results: Few species of Alternanthera genus have been exhaustively investigated phytochemically, and about 129 chemical constituents related to different classes such as flavonoids, steroids, saponins, alkaloids, triterpenoids, glycosides, and phenolic compounds have been isolated from 9 species. Anticancer, antioxidant, antibacterial, CNS depressive, antidiabetic, analgesic, anti-inflammatory, and immunomodulator effects have been explored in the twelve species of the genus. A toxicity study has been conducted on 3 species and a clinical study on 2 species.Conclusions: The available literature on pharmacological studies of Alternanthera species reveals that few species have been selected based on ethnobotanical surveys for scientific validation of their traditional claims. But most of these studies have been conducted on uncharacterized and non-standardized crude extracts. A roadmap of research needs to be developed for the isolation of new bioactive compounds from Alternanthera species, which can emerge out as clinically potential medicines.

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Hepatoprotective effect of chlorogenic acid against chronic liver injury in inflammatory rats

Cited by 33 publications

References 55 publications

Hepatic Inflammatory Response to Exogenous LPS Challenge is Exacerbated in Broilers with Fatty Liver Disease

Hepatic Inflammatory Response to Exogenous LPS Challenge is Exacerbated in Broilers with Fatty Liver Disease

Terpene-rich Fractions of Ficus Mucoso (Welw) Modulate Lipopolysaccharide-induced Inflammatory Mediators and Aberrant Permeability of the Inner Mitochondrial Membrane in Murine Animal Model

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

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