Hepatoprotective effect of curcumin on lindane-induced oxidative stress in male wistar rats

Abstract

Lindane, an organochlorine pesticide, is recognized as a major public health concern because of its potential toxic effects on human health. Its persistence in the body fluids may lead to continuous blood circulation, liver exposure and hepatotoxicity. The present study was undertaken to evaluate the possible protective role of curcumin on lindane-induced hepatotoxicity. Forty-two healthy adult male Wistar rats were divided into seven groups of six rats each. Group I was given dimethylsulfoxide. A single dose of lindane (60 mg/kg bw) was given to group II. Lindane (30 mg/kg bw) was given daily to group III for 14 days. Treatment with curcumin (100 and 200 mg/kg) was given to groups IV and V before (pretreatment) and to groups VI and VII after (post-treatment) 14 days exposure of lindane. Oxidative stress parameters and antioxidative enzymes were investigated in the liver of exposed and treated rats. A significant increase in lipid peroxidation, and decrease in glutathione level, Superoxide dismutase catalase, glutathione-S-transferase, glutathione peroxidase, glutathione reductase and NADPH quinine reductase activities was observed in liver of rats exposed to lindane. Curcumin (Pre- and post-treatment) nearly normalized all these parameters. Histological alterations were also observed in the liver tissue after lindane exposure. Treatment with curcumin significantly prevented the lindane-induced histological alterations. In conclusion, curcumin has protective effect over lindane-induced oxidative damage in rat liver.

Efficacy of trans-2-Hydroxycinnamic acid against Trichlorfon-induced oxidative stress in wistar rats

“…Decrease in the GST activity might be either due to a decrease in GSH or due to an increase in the concentration of electrophiles generated on trichlorfon exposure. Decrease in the GST activity was previously reported in the liver[8] and testes[29] of rats on lindane exposure. The total protein contents in the liver, kidney, and brain of trichlorfon-exposed rats were decreased.…”

“…Exogenous antioxidants from natural plant sources have been widely used to counteract pesticide-induced oxidative stress. [8] Phenolic acids are widespread in the plant kingdom and are known to possess a number of biological activities. [9] The antioxidant activity of phenolic acids, including that of hydroxycinnamic acid derivatives, has been reported.…”

Neuroinflammation, Neurodegeneration, and Depression

“…Curcumin, the active ingredient in turmeric ( Curcuma longa ), has been empirically shown to function as an antioxidant (Ruby et al 1995; Sandur et al 2007a,b; Sharma 1976), hepato- and nephro-protectant (Kiso et al 1983; Singh and Sharma 2011; Venkatesan et al 2000), antimicrobial (De et al 2009; Wang et al 2009), anti-inflammatory (Aggarwal and Harikumar 2009; Jurenka 2009), neuroprotectant (Singla and Dhawan 2012), and antidepressant. The antidepressant effects of curcumin have been primarily reported in stress-induced depression models (Bhutani et al 2009; Kulkarni et al 2008; Li et al 2007; Xu et al 2005a,b).…”

Curcumin and neurodegenerative diseases

“…Despite what are apparent pharmacokinetic limitations, curcumin has been reported to have multiple pharmacological activities and to be effective against a wide variety of diseases due to its anti-carcinogenic (38, 7, 39, 40, 2, 3, 37), hepatoprotective (8, 41–44), thrombosuppressive (45, 46), cardioprotective (47–49), anti-arthritic (9–11), and anti-infectious properties (50–54). …”