Hepatoprotective Effect of Dexmedetomidine Against Radioiodine Toxicity in Rats: Evaluation of Oxidative Status and Histopathologic Changes

Kısmet, Kemal; Sadic, Murat; Bağ, Yusuf Murat; Atilgan, Hasan Ikbal; Koca, Gökhan; Onalan, Ali Kemal; Şeneş, Mehmet; Peker, Seydi Ali; Yumuşak, Nihat; Korkmaz, Meliha

doi:10.9738/intsurg-d-15-00325.1

Cited by 6 publications

(18 citation statements)

References 31 publications

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“…Liver damage is one of the important complications of RAIT. In this study, RAIT caused severe hyperemia, inflammatory cell infiltration, cellular changes, steatosis, as well as bile duct proliferation, fibrosis, and granuloma formation, and led to early significant liver damage as in previous animal studies [9,34]. NAC administration significantly reduced the RAI-induced liver damage.…”

Section: Discussionsupporting

confidence: 77%

“…There are only limited numbers of studies on the preventive treatment of radioiodine-induced liver toxicity. A rat model treated with intraperitoneal dexmedetomidine for preventing RAI-induced early liver damage observed that the rats treated with dexmedetomidine had lower mean scores of histopathologic parameters and lower malondialdehyde levels and higher total sulfhydryl and catalase activities than the RAI group [9]. Similarly, intraperitoneal melatonin treatment decreased the tissue advanced the oxidation of protein products and malondialdehyde levels and increase the total sulfhydryl level as well as reducing the early histopathologic damage of the liver after RAIT [34].…”

Section: Discussionmentioning

confidence: 99%

“…Vasil'ev et al [8] obtained a moderate decrease in absorptive and secretory hepatocyte function associated with both hypothyroidism and radiation factor in thyroid cancer patients received RAIT. In animal studies, it has been shown that RAIT caused significant morphological damage to rat livers in both short and long-term period of treatment [9,10]. It has been observed that the high dose RAI ablation therapy as 75-150 mCi might lead to drug-induced liver injury (DILI) in the thyroidectomized patient [11].…”

Section: Introductionmentioning

confidence: 99%

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Ameliorating effects of N-acetyl cysteine against early liver damage of radioiodine in rats

Kuşkonmaz¹,

Demirel

Koca

et al. 2021

Nuclear Medicine Communications

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Objective The present study was aimed to explore the potential ameliorating effects of N-acetyl cysteine (NAC) against radioiodine (RAI)-induced early liver damage. Methods Thirty Wistar Albino male rats were arbitrarily allocated into three groups each containing 10 rats: the control group (group 1); the RAI group (group 2), oral 111 MBq/kg radioiodine was administered to rats; the RAI + NAC group (group 3), 150 mg/kg/day intraperitoneal NAC treatment was initiated 3 days prior to the RAI administration and continued for 10 days. Liver samples were obtained 24 h after the last dose of NAC therapy for biochemical and histopathologic evaluation. Results In the RAI + NAC group, the histopathologic damage was found significantly less than in the RAI group for whole parameters except inflammatory cell infiltration (P < 0.05). Unlike the RAI group which had marked histopathologic damage, the RAI + NAC group had only mild histologic activity index scores with no granuloma formation observed. Oxidative stress parameters were demonstrated that the NAC treatment significantly decreased the tissue malondialdehyde (MDA) and catalase levels and increased the total sulfhydryl (total sulfhydryl) levels when compared to the RAI group (P < 0.01). Conclusion The outcomes of the study exhibited that the NAC treatment improved RAI-induced early liver damage. This improving effect considered to be caused by its antioxidant, anti-inflammatory, and likely vasodilator properties of NAC. Having advantages such as inexpensive, easy access, and tolerability, the NAC can be used as a radioprotective agent, especially in patients with liver diseases and requiring RAI treatment.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ameliorating effects of N-acetyl cysteine against early liver damage of radioiodine in rats

Kuşkonmaz¹,

Demirel

Koca

et al. 2021

Nuclear Medicine Communications

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“…In addition to its analgesic and sedative effects, dexmedetomidine has an anti-inflammatory effect through the cholinergic anti-inflammatory pathway which improves survival in experimental endotoxemia by inhibiting the inflammatory cytokines release 4 . Furthermore, the protective effect of dexmedetomidine to many organs such as heart, brain, kidney, liver and testis has been demonstrated by enhancing the vagus nerve excitability and producing hemodynamic stability 5 , 6 . Recently, the protective effect of dexmedetomidine preconditioning on IR injury has been shown in heart and in testis tissue experimental models 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

The outcomes of dexmedetomidine and calcitriol on flap viability

et al. 2020

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“…However, besides that it has therapeutically effect on thyroid tissue I-131 can cause some undesirable effects on other organs of the body. One of the undesirable damages of radiation in biological systems is the genotoxic effects on DNA, and the other is the formation of reactive oxygen species (ROS) by interacting with water molecules that are abundant in the cell [3][4][5]. These effects have been revealed up to now, and that radioactive I-131 caused an increase in ROS formation in the body and the DNA damage, have been reported by various researchers [6,7].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the effect of vitamin C on the oxidative stress parameters induced by i-131 treatment applied in patients with hyperthyroidism

Özdemir¹,

Tan²,

Çakır³

et al. 2018

Nucl Med Biomed Imaging

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Aim or purpose:The radioactive I-131 (RAI) treatment is an adjuvant treatment option that increasingly is applied in hyperthyroidism, toxic nodular goitre and Grave's disease. The aim of this study is to investigate the possible radioprotective role of Vitamin C in I-131(RAI) treatment in hyperthyroid patients. Material and methods:The patients who were undergone RAI treatment due to hyperthyroidism divided into 2 groups. While vitamin C was not given to the 1st group (24 patients) during RAI treatment, vitamin C in oral dose 1000 mg / day was given to the 2nd group (28 patients) throughout 1 week starting from 1 day before their treatments. Peripheral blood was drawn twice from the both groups before RAI treatment and on the 7th day after treatment. The oxidative stress parameters which are total antioxidant status (TAS), total oxidant status (TOS), ischemia modified albumin (IMA), malondialdehyde (MDA) were measured by obtaining serum samples, and their blood levels were measured biochemically with ELISA method by applying the 8-hydroxydeoxyguanosine (8-OHdG) kit protocols for DNA damage. The radioprotective effect of the Vit C was investigated as statistically by comparing the oxidative stress parameters that were obtained from both groups. Results and conclusion:According to the results of our study, it was seen that vitamin C reduces the effects of oxidative stress that is caused by radiation, and it was thought that vitamin C supplementation is beneficial for patients to whom therapeutic radioactive materials was undergone.

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Hepatoprotective Effect of Dexmedetomidine Against Radioiodine Toxicity in Rats: Evaluation of Oxidative Status and Histopathologic Changes

Cited by 6 publications

References 31 publications

Ameliorating effects of N-acetyl cysteine against early liver damage of radioiodine in rats

Ameliorating effects of N-acetyl cysteine against early liver damage of radioiodine in rats

The outcomes of dexmedetomidine and calcitriol on flap viability

Investigation of the effect of vitamin C on the oxidative stress parameters induced by i-131 treatment applied in patients with hyperthyroidism

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