Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice

Naaz, Farah; Javed, Saleem; Abdin, Malik Zainul

doi:10.1016/j.jep.2007.07.017

Cited by 90 publications

(51 citation statements)

References 17 publications

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“…Evaluation of the lipid damage is based on measurement of Thiobarbituric acid reactive substances (TBARS) or MDA by the TBA test and conjugated dienes. AFB1 induced an increase in the TBARS concentration in the liver [74] or in human hepatoma cells [75]. The increase of the lipid peroxide synthesis is observed not only in the liver but also in the kidney and brain [7,35,41].…”

Section: Alatoxins and Oxidative Lipid Damagementioning

confidence: 99%

The Effect on Oxidative Stress of Aflatoxin and Protective Effect of Lycopene on Aflatoxin Damage

Yılmaz¹,

Kaya²,

Kisaçam³

2017

Aflatoxin-Control, Analysis, Detection and Health Risks

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Alatoxin (AF) is polysubstituted bifuranocoumarins that are secondary fungal metabolites produced by parasiticus/lavus group of the genus Aspergillus. AF is hepatotoxic, nephrotoxic, mutagenic, teratogenic, genotoxic, and immunotoxic, so the International Agency for Research on Cancer has classiied AF as class I human carcinogen. AF-mediated cell injury may be associated with the release of free radicals, and these radicals initiate lipid peroxidation and a damaging process in biological systems since all cell membranes contain the polyunsaturated faty acids (PUFAs), which are substrates for such a reaction. One of the causes for AF-induced toxicity is the oxidative stress, which leads to the improved generation of reactive oxygen species (ROS) and the oxidative DNA damage. Lycopene, a naturally occurring carotenoid, has drawn a particular atention in recent years because of its high antioxidant activity and free radical scavenging capacity and has been shown to be efective against oxidative stress due to AF. Lycopene blocks Phase 1 metabolic enzymes of AFB such as 3A4, 2A6, and 1A2.

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Section: Alatoxins and Oxidative Lipid Damagementioning

confidence: 99%

The Effect on Oxidative Stress of Aflatoxin and Protective Effect of Lycopene on Aflatoxin Damage

Yılmaz¹,

Kaya²,

Kisaçam³

2017

Aflatoxin-Control, Analysis, Detection and Health Risks

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“…Previous studies using Thonningia sanguinea (Gyamfi and Aniya, 1998) Phyllanthus amarus (Naaz et al, 2007), Zizyphus spina-christi (Abdel-Wahhab et al, 2007), Jatropha curcas (Balaji et al, 2009) and black tea ( Jha et al, 2011) have revealed hepatoprotective effects against AFB 1 induced green ornamental woody plant inhabiting in tropical regions. The leaves of B. spectabilis possesses several medicinal properties viz.…”

Section: Introductionmentioning

confidence: 98%

Does Bougainvillea spectabilis protect Swiss Albino Mice from Aflatoxin-induced Hepatotoxicity?

Mishra¹,

Tandon²,

Dhama³

et al. 2016

Adv. Anim. Vet. Sci.

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| We have investigated the protective effect of oral administration of the ethanolic extract of Bougainvillea spectabilis leaves against aflatoxin B 1 (AFB 1 ) induced hepatic injuries among male Swiss albino mice. AFB 1 exposure has significantly increased (P< 0.05) the lipid peroxidase activity and decreased the activities of various antioxidant enzymes viz. superoxide dismutase (57.58%), catalase (24.14%), glutathione peroxidase (44.21%), glutathione S-transferase (44.07%) and glutathione reductase (13.51%). It also declined the level of ascorbic acid, reduced glutathione and protein contents by 47%, 34% and 24% respectively. It markedly decreased lipid peroxidation (TBARS level) with concomitant stimulation (P < 0.05) of antioxidants (enzymatic and non -enzymatic both). HPTLC analysis revealed availability of sufficient amount of flavonoids, alkaloids and phenolic compounds in the extract of B. spectabilis leaves might be responsible for the improved efficiency of antioxidant system and subsequent protection from aflatoxicity.

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“…Scientific studies have provided solid evidence of this therapeutic effect. Chanca piedra extract is well known for its antioxidant properties, this may result from its ability to scavenge free radicals [14]. The present study is aimed at studying the effects of high and low doses of Chanca Piedra on some renal function parameters in cadmium-induced kidney damage in adult Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

Aberrations in Renal Function Parameters Following Oral Administration of <i>Phyllanthus amarus</i> in Cadmium-Induced Kidney Damage in Adult Wistar Rats

Olubunmi¹

2017

JDMP

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Abstract:Renal disease has been found to be the ninth leading cause of death. Environmental pollution is a serious cause for concern nowadays and the exposure of humans to heavy metals released into the environment by several sources produces deleterious and lethal effects. Cadmium (Cd) which is a non-essential heavy metal known to possess toxic effects on living things can be found almost anywhere and its toxicity is of concern to industrial workers and all humans due to its use in some industrial products and also in agriculture. The chief organ of toxic impact in the human is the kidney, where the proximal tubule is a major target of Cd deposition. The present study investigated if ethanolic extract of Chanca Piedra (CP) (Phyllantus amarus) has any prophylactic or ameliorative effects against nephrotoxicity induced by cadmium sulphate in adult male Wistar rats. A total of forty-two (42) adult male Wistar rats were used for this study and were divided into seven (7) groups (n=6) as follows: Group A (control), Group B (40mg/kg BW), Group C (100mg/kg BW of CP and 40mg/kg BW of Cd), Group D (200mg/kg BW of CP and 40mg/kg BW), Group E (40mg/kg BW and 100mg/kg BW of CP), Group F (40mg/kg BW and 200mg/kg BW of CP), Group G (200mg/kg BW of CP). Both cadmium and Chanca Piedra were administered orally through oro-gastric cannula. Results showed that exposure to Cd lowered the activities of the kidney by increasing the plasma creatinine and urea levels. Exposure to CP also lowered the activities of the kidney by increasing the plasma creatinine and urea levels. The findings suggest that the administration of CP extract has no prophylactic or ameliorative effects on cadmium induced kidney damage and continue use of this extracts in the treatment of some diseases may be deleterious to the kidney.

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Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice

Cited by 90 publications

References 17 publications

The Effect on Oxidative Stress of Aflatoxin and Protective Effect of Lycopene on Aflatoxin Damage

The Effect on Oxidative Stress of Aflatoxin and Protective Effect of Lycopene on Aflatoxin Damage

Does Bougainvillea spectabilis protect Swiss Albino Mice from Aflatoxin-induced Hepatotoxicity?

Aberrations in Renal Function Parameters Following Oral Administration of <i>Phyllanthus amarus</i> in Cadmium-Induced Kidney Damage in Adult Wistar Rats

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Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice

Cited by 90 publications

References 17 publications

The Effect on Oxidative Stress of Aflatoxin and Protective Effect of Lycopene on Aflatoxin Damage

The Effect on Oxidative Stress of Aflatoxin and Protective Effect of Lycopene on Aflatoxin Damage

Does Bougainvillea spectabilis protect Swiss Albino Mice from Aflatoxin-induced Hepatotoxicity?

Aberrations in Renal Function Parameters Following Oral Administration of &lt;i&gt;Phyllanthus amarus&lt;/i&gt; in Cadmium-Induced Kidney Damage in Adult Wistar Rats

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Aberrations in Renal Function Parameters Following Oral Administration of <i>Phyllanthus amarus</i> in Cadmium-Induced Kidney Damage in Adult Wistar Rats