2005
DOI: 10.1111/j.1478-3231.2005.01068.x
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Hepatoprotective effect of ginsenoside Rb1 and compound K on tert‐butyl hydroperoxide‐induced liver injury

Abstract: Compound K, which was produced from ginsenosides of Panax ginseng in intestine, could protect liver injury.

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Cited by 168 publications
(95 citation statements)
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“…Especially, the metabolites of ginsenosides that are formed by enteric bacteria have been focused on for their pharmacological activities. Among them, compound K (C-K) is known to be formed by enteric bacterial fermentation of Rb1, Rb2 and RC, and C-K has been reported to suppress tumor metastasis and inflammatory responses (6,7). Another ginsenoside Rh2, a metabolite of Rg3, is also known for its tumor suppression by inducing apoptosis or retarding growth signals (8).…”
Section: Proapoptotic Ginsenosides Compound K and Rh2 Enhance Fas-indmentioning
confidence: 99%
“…Especially, the metabolites of ginsenosides that are formed by enteric bacteria have been focused on for their pharmacological activities. Among them, compound K (C-K) is known to be formed by enteric bacterial fermentation of Rb1, Rb2 and RC, and C-K has been reported to suppress tumor metastasis and inflammatory responses (6,7). Another ginsenoside Rh2, a metabolite of Rg3, is also known for its tumor suppression by inducing apoptosis or retarding growth signals (8).…”
Section: Proapoptotic Ginsenosides Compound K and Rh2 Enhance Fas-indmentioning
confidence: 99%
“…Male C57BL/6 mice (6-8 weeks of age) were obtained from the BioLASCO Experimental Animal Center (Taipei, Taiwan) and housed in temperature-controlled ventilated cages on a 12/12-hour light/dark cycle (22 6 2°C, 30%-70% humidity) at the animal center of the National Defense Medical Center. The mice were randomly separated into control or Rg1 groups and orally treated by gavage with 1% dimethylsulfoxide or Rg1 (20 mg/kg, dissolved in 1% dimethylsulfoxide), respectively (Lee et al, 2005). The mice were sacrificed after 30 hours of drug treatment.…”
Section: D-[mentioning
confidence: 99%
“…After inducing AD-like skin lesions, skin lesions were treated with Dulbecco's phosphate buffered saline vehicle, dexamethasone (positive control), or Rb 1 (50 and 100 μg/mL) every other day (four times in total). The concentrations of Rb 1 were selected based on previous reports [15]. To compare the improvement of skin condition by treatment with each compound, pictures were taken before and after the treatment.…”
Section: Induction and Treatment Of Atopic Dermatitis-like Skin Lesiomentioning
confidence: 99%