Inhibitory Effects of Ginsenoside Rb₁on Atopic Dermatitis-Like Skin Lesions in Mice

The effect of Korean red ginseng on allergic inflammation in a murine model of allergic rhinitis

“…Meanwhile, the ginsenoside Rd can significantly increase the production of OVA-specific IgG, IgG1, and IgG2b levels in mice immunized with OVA, which exhibit immunological adjuvant activity [23]. In an mouse model of atopic dermatitis, the topical application of Rb1 did not reduce total serum IgE levels [24]. In contrast to these previous reports, our findings indicate that KRG can reduce total serum IgE production but does not appear to induce the production of IgG.…”

“…In a mouse model of atopic dermatitis, the topical application of Rb1 on skin lesions improved the lesions. Rb1 also suppressed the mRNA expression of IL-4, IL-10 and nuclear factor of activated T cells in splenocytes [24]. An extract of the root of P. notoginseng , which contains the ginsenosides Rb1, Rg1, and Rd and the notoginsenoside R1, significantly inhibited the inflammatory response by blocking the production of NO, PGE 2 , TNF-α, and IL-1β [30] and by suppressing the NF-κB signaling pathway [30,31].…”

Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model

“…The total clinical severity score evaluating itching, erythema/hemorrhage, edema, excoriation/ erosion, and scaling/dryness was significantly reduced by KRG. Topical application of KRG and ginsenosides Rh2 and Rg3 have shown efficacy in other recent studies as well (Kim et al, 2011;Park et al, 2010;Sohn et al, 2011). Topical application of KRG and ginsenosides Rh2 and Rg3 resulted in improved AD-like skin lesions, and led to a decrease in the mRNA expression of IL-4 (Kim et al, 2011;Park et al, 2010;Sohn et al, 2011).…”

Anti-apoptotic Activity of Ginsenoside Rb1in Hydrogen Peroxide-treated Chondrocytes: Stabilization of Mitochondria and the Inhibition of Caspase-3

“…Over 40 ginsenosides have been identified; each ginsenoside shows different biological activities based on structural differences. The ginsenosides Rb 1 (G-Rb 1 ), one of the most extensively studied of the ginsenosides, and they have been shown to have a variety of biological ac tivities, including anti-inflammatory, and anti-allergic activities anti-allergic activities [2]. However, the anti-arthritic and anti-apoptotic effects of G-Rb 1 have not been reported.…”