Hepatoprotective effect of <i>Chenopodium murale</i> in mice

Abstract

Discovery of drugs has its roots in medicinal plants that appeal researchers to identify new therapeutical entities from plants. The current study was conducted to determine its hepatoprotective activity. The results showed that aqueous methanolic extract of Chenopodium murale (200 and 500 mg/kg) produced significant (p<0.001) decrease in paracetamol induced increased levels of liver enzymes (alanin transaminase, aspartate transaminase, alkaline phosphatase) and total bilirubin. These findings were further supported by histopathological investigations by microscope and detection of phytoconstituents having hepatoprotective potential e.g. qurecetin, kaempferol and gallic acid by HPLC. Conclusively aqueous methanolic extract of C. murale possess hepatoprotective activity against paracetamol induced liver damage in mice.

Hepatoprotective effect of aqeous methanolic extract of <i>Rumex dentatus</i> in paracetamol induced hepatotoxicity in mice

“…So there is an urgent need to investigate the natural plants and isolate their constituents which can be beneficial to control liver diseases (Ravikumar et al, 2012). It has been seen that many herbal plants are found to be hepatoprotective such as Cichorium intybus (Heibatollah et al, 2008), Luminet racemosa (Gnanadesigan et al, 2011), Solanum nigrum (Raju et al, 2003), Hibiscus vitifolius (Samuel et al, 2012), Chenopodium murale (Saleem et al, 2014), Trichodesma sedgwickianum (Saboo et al, 2013), Oflpomoea staphylina (Bag and Mumtaz, 2013), Convolvulus arvensis (Ali et al, 2013), Suaeda fruticosa (Rehman et al, 2013) and Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala .…”

Cytotoxic effect of methanol extract of <i>Conyza bonariensis</i> on DMBA-induced skin carcinogenesis: An <i>in vivo</i> study

“…Isocratic: dichloromethane: methanol (60:20:20) was used as the mobile phase with the flow rate of 1 mL/min. The column was ODS 250 mm x 4.6 mm and UV detector was used to obtain chromatogram at 280 nm at room temperature (Saleem et al, 2014).…”

“…Preliminary phyto-chemical screening methanol extract of C. bonariensis was performed according to the procedure described elsewhere (Saleem et al, 2014).…”

“…So, it is direly needed to explore new anticancer agents from plants which can effectively kill cancer cells without damaging normal body cells. (Saleem at al, 2014), Catharanthus roseus (Cragg and Newman, 2005;Okouneva et al, 2003;Simeons et al, 2008), Podophyllum peltatum and Podophyllum emodi (Shoeb et al, 2006), Taxus brevifolia Nutt, Taxus baccata (Kingston, 2007;Hait et al, 2007), Camptotheca acuminate (Zhang et al, 2004, Fuchs et al, 2006, Berberis amarensis (Xie et al, 2009;Xu et al, 2006), Hvdrastis canadensis L (Wang et al, 2011;Patil et al, 2010), Tabebuia avellanedae (Li et al, 2000;De Almeida, 2009), Betula alba (Fulda, 2008), Colchicum autumnale (Dubey et al, 2008), Curcuma longa (Sa et al, 2010;Goel et al, 2008), Wikstroemia indica Diogo et al, 2009), Psoralea corylifolia (Moon et al, 2006;Dixon and Ferreira, 2002), Ochrosia elliptica (Kuo et al, 2006), Amoora rohituka and Dysoxylum binectariferum (Mans et al, 2000), Euphorbia peplus L. (Hampson et al, 2005), Ipomoeca batatas L (Ancuceanu and Istudor, 2004), Salvia prionitis (Deng et al, 2011), Centaurea schischkinii (Shoeb et al, 2005) have been known to possess anticancer activity.…”

Hepatoprotective activity of methanolic extract of <i>Malva parviflora</i> against paracetamol-induced hepatotoxicity in mice

“…The plant kingdom still holds many species containing substances of medicinal value which have yet to be discovered: Large numbers of plants are constantly being screened for their possible pharmacological value particularly for their antiinflammatory , hypotensive (Qadir, 2010), hypoglycemic, amoebicidal, anti-fertility, cytotoxic, antibiotic (Amin et al, 2012), spasmolytic, bronchodilator (Bashir et al, 2013, antioxidant and hepatoprotective properties . Many plants have been identified as hepatoprotective like Trianthema decandra (Balamurugan and Muthusamy, 2008), Cocculus hirsutus (Thakare et al, 2009), Carica papaya (Sadeque andBegum, 2010), Carissa spinarum (Hegde and Joshi, 2010), Convolvulus arvensis (Ali et al, 2013), Dodonaea viscosa (Khan et al, 2013), Trichodesma sedgwickianum (Saboo et al, 2013), OfIpomoea staphylina (Bag and Mumtaz, 2013), Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (Akhtar et al, 2013), Cestrum nocturnum (Qadir et al, 2014a), Viola odorata (Qadir et al, 2014b), Chenopodium murale (Saleem et al, 2014) and Morus nigra (Mallhi et al, 2014).…”