Hepatoprotective effect of Lycopodium clavatum 30CH on experimental model of paracetamol-induced liver damage in rats

Silva, Gustavo Henrique da; Barros, Pedro Paulo; Gonçalves, Gisele Mara Silva; Landi, Matheus Arnosti

doi:10.1016/j.homp.2014.05.005

Cited by 19 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results, proving the antioxidant potential of Lyc, are in line with a previous study of a Lyc-enhanced antioxidant response in aging mice [42]. Lyc has also been reported to protect against cognitive [43], inflammatory [24,25] and neuronal [36,42] damage.…”

Section: Discussionsupporting

confidence: 92%

“…It has been a popular remedy in traditional Chinese and homeopathic medicines for centuries [18,19,20]. It has also been reported to possess anti-cancer [21,22], analgesic [23] and anti-inflammatory [24,25,26] properties. Lycopodium alkaloids, such as quinolizine or pyridine and α-pyridone-types, have been reported to possess acetylcholinesterase inhibition activity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson’s Disease

et al. 2019

View full text Add to dashboard Cite

Parkinson’s disease, a chronic, age related neurodegenerative disorder, is characterized by a progressive loss of nigrostriatal dopaminergic neurons. Several studies have proven that the activation of glial cells, presence of alpha-synuclein aggregates, and oxidative stress, fuels neurodegeneration, and currently there is no definitive treatment for PD. In this study, a rotenone-induced rat model of PD was used to understand the neuroprotective potential of Lycopodium (Lyc), a commonly-used potent herbal medicine. Immunohistochemcial data showed that rotenone injections significantly increased the loss of dopaminergic neurons in the substantia nigra, and decreased the striatal expression of tyrosine hydroxylase. Further, rotenone administration activated microglia and astroglia, which in turn upregulated the expression of α-synuclein, pro-inflammatory, and oxidative stress factors, resulting in PD pathology. However, rotenone-injected rats that were orally treated with lycopodium (50 mg/kg) were protected against dopaminergic neuronal loss by diminishing the expression of matrix metalloproteinase-3 (MMP-3) and MMP-9, as well as reduced activation of microglia and astrocytes. This neuroprotective mechanism not only involves reduction in pro-inflammatory response and α-synuclein expression, but also synergistically enhanced antioxidant defense system by virtue of the drug’s multimodal action. These findings suggest that Lyc has the potential to be further developed as a therapeutic candidate for PD.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson’s Disease

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Serum AST and ALT liver function biomarkers are inversely related to the severity of liver damage [ 66 – 68 ]. We found that both ALT and AST levels were significantly higher in the 2/3 PH group mice than in the sham group mice on day 2 and day 4 after 2/3 PH and that RD treatment reversed these changes.…”

Section: Discussionmentioning

confidence: 99%

Resina Draconis Reduces Acute Liver Injury and Promotes Liver Regeneration after 2/3 Partial Hepatectomy in Mice

Lou

Zhao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Aim. To investigate the protective effects and possible mechanisms of action of resina draconis (RD) on acute liver injury and liver regeneration after 2/3 partial hepatectomy (PH) in mice. Methods. 2/3 PH was used to induce acute liver injury. Mice were divided into three groups: sham, vehicle + 2/3 PH, and RD + 2/3 PH. Resina draconis was administered intragastrically after 2/3 PH into the RD + 2/3 PH group, and the same volume of vehicle (1% sodium carboxymethyl cellulose) was injected into the vehicle + 2/3 PH group and sham group mice. The index of liver to body weight (ILBW) and proliferating cell nuclear antigen (PCNA) were assayed to evaluate liver regeneration. Blood and liver tissues were collected for serological and western blotting analysis. Results. Resina draconis protected against 2/3 PH-induced acute severe liver injury and promoted liver regeneration as shown by significantly increased ILBW compared with that of controls. 2/3 PH increased serum AST and ALT levels, which were significantly decreased by RD treatment, while 2/3 PH decreased serum TP and ALB, which were increased by RD treatment. In the RD + 2/3 PH group, PCNA expression was significantly increased compared with the 2/3 PH group. Further, hepatocyte growth factor (HGF), TNFα, and EGFR levels were increased in the RD group at postoperative days 2 and 4 compared with the those in the 2/3 PH group. Conclusion. Our results suggest that RD ameliorates acute hepatic injury and promotes liver cell proliferation, liver weight restoration, and liver function after 2/3 PH, probably via HGF, TNFα, and EGFR signaling.

show abstract

“…Our research selected a homeopathic solution to be investigated, as this type of treatment has been effectively used in several managements, fighting the disease itself or the effects caused by the conditions. Several studies demonstrate the effectiveness of homeopathy in the treatment of multiple sclerosis 21 ; chronic prostatitis due to radiation 22 ; acute radiodermatitis 23 ; cancerous lesion 24 ; xerostomia 25 , DNA damage, and oxidative stress 26 ; and as hepatoprotective 27 .…”

Section: Discussionmentioning

confidence: 99%

Effect of homeopathy in the function and morphology of salivary parotid glands of irradiated rats

et al. 2020

View full text Add to dashboard Cite

Objective: To evaluate the radioprotective effect of a homeopathic solution in salivary function and in parotid glands morphology of irradiated rats. Materials and Methods: The sample consisted of 150 rats randomly divided in 6 groups. The groups were named based on the substance administered: Control- saline solution; Irradiated Control- saline solution and 15 Gy of X radiation; Alcohol-hydroalcoholic solution dynamized at 15 CH; Irradiated Alcohol- hydroalcoholic solution dynamized at 15 CH and 15 Gy of X radiation; Homeopathy- 0.25 ml (1mL/kg) of the irradiated hydroalcoholic solution and dynamized at 15 CH; Irradiated homeopathy- homeopathic solution and 15 Gy of X radiation. Each group was subdivided in 5 different subgroups, based on the time point of euthanasia: 12 hours, 3, 10, 17, and 24 days. The medication was administered for 7 days before and 7 days after the radiation treatment. On the day of euthanasia, salivation was induced with pilocarpine and collected. The animals were then sacrificed and the parotid glands were removed. Results: Salivary function analysis showed that only group irradiated homeopathy euthanized on day 17 had a statistical significant difference when compared to other irradiated groups, presenting a higher salivation flow rate. The only group that showed statistical significant difference in the number of acini over the time was the irradiated alcohol group, which presented a tendency of reduction. Conclusion: The homeopathic solution presented a late radioprotective effect based on salivary function and morphological analysis of the parotid gland.

show abstract

Hepatoprotective effect of Lycopodium clavatum 30CH on experimental model of paracetamol-induced liver damage in rats

Abstract: Lyc 30c exerted a moderate hepatoprotective effect on acute Pct-induced hepatitis, mainly shown by a histological decrease in necrosis and inflammatory foci, preserved glycogen and other 1,2-glycols in zone 3 and reduced serum levels of ALT and AST.

Cited by 19 publications

References 22 publications

Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson’s Disease

Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson’s Disease

Resina Draconis Reduces Acute Liver Injury and Promotes Liver Regeneration after 2/3 Partial Hepatectomy in Mice

Effect of homeopathy in the function and morphology of salivary parotid glands of irradiated rats

Contact Info

Product

Resources

About