Hepatoprotective effect of methanol extracts of Zingiber officinale and Cichorium intybus

Abstract

The present work was carried out to investigate the hepatoprotective effect of ginger, chicory and their mixture against carbon tetrachloride intoxication in rats. Carbon tetrachloride treatment significantly elevated the alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma glutamyltransferase activities and the serum triglycerides and cholesterol concentration as compared to control group. It also increased RBCs counts and Hb concentration, total or differential leucocytes counts. However it decreased platelet counts, platelet distribution width, mean platelet volume, platelet larger cell ratio. Methanol extract of ginger (250 and 500 mg/kg) and chicory (250 and 500 mg/kg) given alone or mixed (1:1 wt/wt) significantly restored the carbon tetrachloride-induced alterations in the biochemical and cellular constituents of blood. No toxic symptoms were reported in doses up to 5 g/kg. Alkaloids and/or nitrogenous bases, carbohydrates and/or glycosides, tannins, flavonoids, saponins and unsaturated sterols and/or triterpenes are the main active constituents of their methanol extract. The hepatoprotective effect of ginger and chicory was also confirmed by the histopathological examination of liver tissue.

Antidiabetic effect of combined spices ofAllium sativum,Zingiber officinaleandCapsicum frutescensin alloxan-induced diabetic rats

“…However, diabetic rats treated with combined spice extract or glibenclamide showed hepatocytes with nearly normal appearance and minimal necrosis. The hepatoprotective activity of the combined spices may be due to the combined free-radical scavenging activities of polyphenols, especially flavonoids, in the spices (Atta et al 2010).…”

Evaluation of Hepatocyteprotective and Anti-hepatitis B Virus Properties of Cichoric Acid from <i>Cichorium intybus</i> Leaves in Cell Culture

“…4,5) Cichorium intybus is widely used medicinally and has been investigated for its potent hepatoprotective activity. [6][7][8][9] Cichoric acid has been shown to possess phagocytosis stimulatory activity in vitro and in vivo, to inhibit hyaluronidase and to protect collagen type III from free radical induced degradation. 10) What is more important is that chicoric acid also exhibits significant antiviral effects against human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus (HSV-I).…”

Hepatoprotective and Antioxidant Activities of Tribulus Terrestris

“…The rise in serum levels of AST and ALT has been attributed to the damaged structural integrity of the liver, because they are cytoplasmic in location and released into the circulation subsequent to cellular damage. The rise in the level of serum bilirubin is the most sensitive and confirms the intensity of jaundice (Krishna Mohan et al, 2007;Atta et al, 2010).…”

“…Pretreatment of rats with the total ethanolic extract of the aerial parts of T. terrestris at a dose of 500 mg/kg induced a statistically significant decrease in the levels of AST, ALT and bilirubin, as well as, a significant increase in the level of serum albumin where stimulation of protein synthesis has been reported as a contributory hepatoprotective mechanism as it accelerates the regeneration process and the production of liver cells (Krishna Mohan et al, 2007;Atta et al, 2010).…”