Hepatoprotective effect of picroliv against rifampicin-induced toxicity

Saraswat, Binduja; Visen, P. K. S.; Patnaik, G. K.; Dhawan, B. N.

doi:10.1002/(sici)1098-2299(199704)40:4<299::aid-ddr3>3.0.co;2-e

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…Among all the treated groups the hepatoprotective activity was more in the animals treated with phytoconstituent 6heptadecylcyclohex-3-ene-1 carboxylic acid. Similar type of investigations on the effect of phytoconstituents isolated from the medicinal plants in restoring the levels of liver function markers was reported [21][22][23][24].…”

Section: Resultssupporting

confidence: 55%

Hepatoprotective Activity of 6-Heptadecylcyclohex -3-ene-1 Carboxylic Acid Isolated from the Methanol Extract of Dichrostachys cinerea Wight & Arn. Stem Bark

Babu¹,

Krishna²,

Bhavya³

2023

EJMP

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Aim of the Study: The phytoconstituent 6-heptadecylcyclohex 3-ene-1 carboxylic acid isolated from the methanol extract of Dichrotachys cinerea Wight. stem bark was evaluated for hepatoprotective activity against CCl4 induced toxicity. Materials and Methods: The constituent 6-heptadecylcyclohex 3-ene-1 carboxylic acid isolated from the methanolic extract of D. cinerea and the structure was confirmed by spectroscopic studies. Hepatoprotective property was screened in male wistar strain rats. The parameters studied were estimation of liver function serum markers such as serum total bilirubin, total protein, alanine transaminase, aspartate transaminase, alkaline phosphatase and histological profile of the liver tissue. Results: The LD50 of methanolic extract and constituent, 6-Heptadecylcyclohex -3-ene-1 carboxylic acid were evaluated and found to be 500 and 100 mg/kg body weight respectively. The hepatoprotective activity of constituent was more significant as similar to the standard hepatoprotective drug silymarin. The histological profile of the liver tissue showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration as similar to the controls. Conclusion: The methanolic extract of D. cinerea stem bark and the phytoconstituent 6-heptadecylcyclohex-3-ene-1 carboxylic acid showed significant protection from CCl4 induced liver damage.

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Section: Resultssupporting

confidence: 55%

Hepatoprotective Activity of 6-Heptadecylcyclohex -3-ene-1 Carboxylic Acid Isolated from the Methanol Extract of Dichrostachys cinerea Wight & Arn. Stem Bark

Babu¹,

Krishna²,

Bhavya³

2023

EJMP

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“…Picroliv was found to be a more potent choleretic and anticholestatic agent than flavonolignan and silymarin [18]. Picroliv induces the bile salt-dependent fraction (BSDF), thereby increasing the synthesis of bile salts and bile acids, and enhancing conjugation with proteins [15].…”

Section: Choleretic and Anticholestatic Actionsmentioning

confidence: 99%

“…The active ingredient, picroliv, has been shown to produce hepatoprotective activity against thiocetamide, galactosamine, rifampicin and cadmium‐induced liver toxicity in cell culture and in experimental animals [13–16]. At doses of 6 and 12 mg/kg, picroliv provided hepatoprotection against carbon tetrachloride (CCl 4 )‐induced alterations in biochemical parameters, viz.…”

Section: Picroliv and Other Phytochemical Constituents From Picrorhizmentioning

confidence: 99%

Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin

Girish

Pradhan

2008

Fundamemntal Clinical Pharma

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The use of herbal drugs for the treatment of liver diseases has a long tradition in many eastern countries. The easy accessibility without the need for laborious pharmaceutical synthesis has drawn increased attention towards herbal medicines. Few herbal preparations exist as standardized extracts with major known ingredients or even as pure compounds. Some of the herbals, which show promising activity, are ellagic acid for antifibrotic treatment, phyllanthin for treating chronic hepatitis B, glycyrrhizin to treat chronic viral hepatitis and picroliv for liver regeneration. These compounds, which have proven antioxidant, antiviral or anticarcinogenic properties, can serve as primary compounds for further development as hepatoprotective drugs. This review provides the chemistry, pharmacology and future aspects of picroliv, ellagic acid and curcumin with focus on hepatoprotective properties. These phytochemicals may prove to be very useful in the treatment of hepatotoxicity induced by viral agents, toxic drugs and plant poisons. The high safety profile may be an added advantage. However, poor bioavailability and temperature and light sensitivity can reduce the efficacy of drugs like curcumin. In future, the derivatives or new combinations of these drugs may prove to be useful.

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“…11 We strive to establish the no observable effect level (NOEL) -a key determinant of the safe dosage range -and elucidate the nuanced interplay of these herbal constituents when administered in combination. [12][13][14][15][16][17][18] Our approach integrates traditional wisdom with contemporary scientific rigor to unravel the complex safety dynamics of NVK. By doing so, we contribute to the body of knowledge surrounding herbal formulations and their potential for sustained therapeutic use.…”

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confidence: 99%

Chronic Toxicity Investigations with Nilavembu Kudineer in Sprague-Dawley Rats

Sukkur,

Samuel,

et al. 2024

IJPQA

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The safety assessment of Nilavembu Kudineer (NVK), a polyherbal formulation with a wide spectrum of medicinal applications, was meticulously conducted in Sprague-Dawley rats. Over the course of 90 days, NVK was orally delivered at dosages of 100, 200, and 400 mg/kg to test for chronic toxicity. The results of this research provide important information on the relative safety of NVK and its possible effects on human health. Neither death nor any treatment-related adverse clinical manifestations were recorded during the chronic investigation. Feed intake and body weight increase were similar across animals given NVK, with the exception of a little decrease in females in the 200 and 400 mg/kg groups. No adverse findings were found in the ocular investigations performed as part of the safety study. Comprehensive analyses of urinalysis, hematological parameters, and biochemical markers subsequent to NVK administration identified minor alterations in select parameters at distinct dose levels, without any overarching systemic effects. Importantly, both gross and histopathological examinations revealed an absence of lesions directly attributable to NVK treatment. The findings contribute substantial insights to the realm of herbal medicine, providing a solid foundation for the responsible integration of NVK into diverse healthcare contexts.

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Hepatoprotective effect of picroliv against rifampicin-induced toxicity

Cited by 7 publications

References 9 publications

Hepatoprotective Activity of 6-Heptadecylcyclohex -3-ene-1 Carboxylic Acid Isolated from the Methanol Extract of Dichrostachys cinerea Wight & Arn. Stem Bark

Hepatoprotective Activity of 6-Heptadecylcyclohex -3-ene-1 Carboxylic Acid Isolated from the Methanol Extract of Dichrostachys cinerea Wight & Arn. Stem Bark

Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin

Chronic Toxicity Investigations with Nilavembu Kudineer in Sprague-Dawley Rats

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