Hepatoprotective effect of red ginger rhizome extract in deep frying oil-fed male wistar rats

Sunarti, Sunarti; Fachrial, Edy; Harahap, Urip; Delyuzar, Delyuzar; Widyawati, Tri; Lubis, Lokot Donna

doi:10.18051/univmed.2017.v36.228-235

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…The preparation of deep-fried palm oil was carried out according to previously described methods 13 , 28 with minor modification based on information gathered from street food vendors around Jimma University, Jimma. Palm oil was purchased from the market, Jimma, Ethiopia.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Effect of Hydromethanolic Seed Extract of Lepidium sativum L. (Fetto) on Deep-fried Palm Oil Diet Induced Nonalcoholic Fatty Liver Disease on Male Swiss Albino Mice

Tofik

Zawdie

Nair

et al. 2022

HMER

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Introduction Nonalcoholic fatty liver disease (NAFLD) is the most prevalent disease due to a dramatic change in dietary habits, especially an increase in consumption of fat and carbohydrates in deep-fried foods. Objective The objective was to evaluate the effect of hydromethanolic seed extract of Lepidium sativum on deep-fried palm oil diet induced NAFLDon male mice. Methods An experimental study design was conducted. Twenty-four male mice aged 8 to 10 weeks, weighing 32–42 g were divided into four groups. The four groups were divided into two controls and two treatments. Mice in normal control (C 0 ) were administered only with the basal diet whereas negative control (C 1 ) provided only with the deep-fried palm oil diet. The treatment groups T 1, and T 2 were administered with deep-fried palm oil diet and HMSELS at dose of 200 and 400 mg/kg/day, respectively for 28 days. Then on day 29, the mice were fasted overnight, anaesthetized and sacrificed by cervical dislocation after blood was taken by cardiac puncture for liver function tests while liver tissues were taken for histopathology investigation. Results The serum ALT and total bilirubin showed significant decrement whereas the serum albumin levels showed significant increment in T 2 group. However, serum AST and ALP levels were decreased significantly in both T 1 and T 2 groups. Besides, the T 2 group liver sections of mice were showed better effect of HMSELS on restoring the damaged liver histopathology almost toward normal. Conclusion The HMSELS at a dose of 400 mg/kg/day (T 2 ) was more effective on the liver function tests and liver histopathology that altered by feeding deep-fried palm oil diet. The good protective effect of HMSELS against deep-fried palm oil diet-induced NAFLD might be due to its antioxidant content.

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Section: Methodsmentioning

confidence: 99%

Evaluation of the Effect of Hydromethanolic Seed Extract of Lepidium sativum L. (Fetto) on Deep-fried Palm Oil Diet Induced Nonalcoholic Fatty Liver Disease on Male Swiss Albino Mice

Tofik

Zawdie

Nair

et al. 2022

HMER

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show abstract

“…Hypercholesterolemia results from increased cholesterol levels and increased production of free radicals. Phenolic compounds reduce the risk of hypercholesterolemia by (1) increasing the activity of antioxidant enzymes, (2) decreasing the formation of free radicals, hydroxyl radicals, and superoxide anions, (3) inhibiting lipid peroxidation, and (4) regulating low-density lipoprotein (LDL) receptors [ 54 ].…”

Section: Biological Activities and Molecular Mechanisms Of Red Gingermentioning

confidence: 99%

Zingiber officinale var. rubrum: Red Ginger’s Medicinal Uses

et al. 2022

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Zingiber officinale var. rubrum (red ginger) is widely used in traditional medicine in Asia. Unlike other gingers, it is not used as a spice in cuisines. To date, a total of 169 chemical constituents have been reported from red ginger. The constituents include vanilloids, monoterpenes, sesquiterpenes, diterpenes, flavonoids, amino acids, etc. Red ginger has many therapeutic roles in various diseases, including inflammatory diseases, vomiting, rubella, atherosclerosis, tuberculosis, growth disorders, and cancer. Scientific evidence suggests that red ginger exhibits immunomodulatory, antihypertensive, antihyperlipidemic, antihyperuricemic, antimicrobial, and cytotoxic activities. These biological activities are the underlying causes of red ginger’s therapeutic benefits. In addition, there have been few reports on adverse side effects of red ginger. This review aims to provide insights in terms the bioactive constituents and their biosynthesis, biological activities, molecular mechanisms, pharmacokinetics, and qualitative and quantitative analysis of red ginger.

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“…Then, the extract is evaporated using a rotary evaporator at a temperature range of 40-60°C until it thickens. The result is then applied with a porcelain dish until a thick extract is obtained [13].…”

Section: Preparation Of R Nasutus Extractmentioning

confidence: 99%

Effects of Ethanolic Extract of Rhinacanthus Nasutus (L) Kurz as an Antimicrobial Against Escherichia Coli Bacteria Using in Vitro Method

M.Biomed

Paninsari

2019

Asian J Pharm Clin Res

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Objective: The objective of this study was to discover of the ethanolic extract of Rhinacanthus nasutus (L) Kurz in inhibiting Escherichia coli bacteria using an in vitro method. Methods: This is an experimental study using a laboratory test with Kirby-Bauer or paper disc method by observing and measuring the inhibition zone of the ethanolic extract of R. nasutus against E. coli bacteria with extract concentrations of 15%, 30%, and 60% consisting of control groups and treatment group. The positive control group used chloramphenicol antibiotics and negative control groups used Aquadest. E. coli was incubated at 37°C for 24 h. Then, the plates were incubated for 24 h at 37°C and the diameter of the inhibition zone was observed until the 3rd day with three repetitions. Results: The results of the study showed that the mean inhibition zone of E. coli bacteria was 10.93 mm, 12.09 mm, and 18.90 mm. The results of the Shapiro–Wilk test were p=0.199. The results of the one-way analysis of variance test were p<0.05 and that of the post hoc test indicated a significant value of p<0.05. Based on the results of the research, there were significant differences in the inhibition zone between the control group and the treatment group at a concentration of 15%, 30%, and 60%. Conclusion: R. nasutus extract was effective to inhibit the growth of E. coli bacteria at concentrations of 15%, 30%, and 60%, so R. nasutus is effective as an antimicrobial.

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Hepatoprotective effect of red ginger rhizome extract in deep frying oil-fed male wistar rats

Cited by 4 publications

References 20 publications

Evaluation of the Effect of Hydromethanolic Seed Extract of Lepidium sativum L. (Fetto) on Deep-fried Palm Oil Diet Induced Nonalcoholic Fatty Liver Disease on Male Swiss Albino Mice

Evaluation of the Effect of Hydromethanolic Seed Extract of Lepidium sativum L. (Fetto) on Deep-fried Palm Oil Diet Induced Nonalcoholic Fatty Liver Disease on Male Swiss Albino Mice

Zingiber officinale var. rubrum: Red Ginger’s Medicinal Uses

Effects of Ethanolic Extract of Rhinacanthus Nasutus (L) Kurz as an Antimicrobial Against Escherichia Coli Bacteria Using in Vitro Method

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