Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachloride-induced acute liver damage in rats

Orhan, Didem Deliorman; Orhan, Nilüfer; Ergun, Ender; Ergün, Fatma

doi:10.1016/j.jep.2007.02.013

Cited by 102 publications

(84 citation statements)

References 21 publications

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“…This result was already observed in grapevine leaves from Vitis labrusca (Dani et al 2010), and in grape juices, where organic juice was shown to be richer in polyphenols than conventional juice (Dani et al 2008a). Grapevines leaves are rich in phenolic compounds and have shown signifi cant antioxidant activity in vitro and in vivo (Monagas et al 2006, Kosar et al 2007, Orhan et al 2007, Pari and Suresh 2008, Dani et al 2010, Oliboni et al 2011.…”

Section: Introductionmentioning

confidence: 62%

Evaluation of antioxidant activity of grapevine leaves extracts (Vitis labrusca) in liver of Wistar rats

Schaffer

Wohlenberg

Medeiros

et al. 2016

An. Acad. Bras. Ciênc.

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The aim of this study was to evaluate the hepatoprotection of organic and conventional grapevine leaves extract (Vitis labrusca). The total polyphenol content and the isolate polyphenols by HPLC were evaluate. The animals received intraperitoneal injections of saline or extracts (conventional or organic -30 mg/kg) for 14 days. On day 15, the rats received carbon tetrachloride (CCl 4 ) or mineral oil (i.p.). After 4h, the animals were euthanized. The analysis of the liver enzymes activity (AST, ALT, GGT) was performed using serum, obtained by blood and the levels of lipid peroxidation (TBARS), protein oxidation (carbonyl), and the activity of antioxidant enzymes superoxide dismutase and catalase were analyzed in the liver. The results showed that the organic extract is richer in polyphenol and resveratrol than the conventional one. Both extracts prevent lipid peroxidation and protein oxidation generated by CCl 4 . Moreover, the extracts demonstrated ability to modulate the activity of SOD and CAT, as well as to establish a balance in the ratio of SOD/CAT. We also found that the CCl 4 increased the levels of AST and GGT, and that both extracts prevent this. These results indicate that grapevine leaves extracts, both, organic and conventional, can prevent liver disorders.

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Section: Introductionmentioning

confidence: 62%

Evaluation of antioxidant activity of grapevine leaves extracts (Vitis labrusca) in liver of Wistar rats

Schaffer

Wohlenberg

Medeiros

et al. 2016

An. Acad. Bras. Ciênc.

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“…It has already been shown that ethanol extracts of V. vinifera were able to induce a hepatoprotective action on carbon tetrachloride-induced acute liver damage in rats, which was attributed to the polyphenolic compounds (Orhan et al 2007). Data about assays performed in kidney and heart tissues with grape leaf extracts are absent in the literature.…”

Section: Resultsmentioning

confidence: 98%

“…free radical scavenging activity and lipid peroxidation inhibition (Orhan et al 2006). Moreover, according to Orhan et al (2007), mainly condensed tannins and flavonoids were suggested to contribute to the antidiabetic activity and prevention of lipid peroxidation of Vitis vinifera leaves. However, in this study, no correlation was found between total phenolic content and antioxidant activity of the fractions, and we suppose that all compounds are important, not only one.…”

Section: Resultsmentioning

confidence: 99%

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Hepatoprotective, cardioprotective, and renal-protective effects of organic and conventional grapevine leaf extracts (Vitis labrusca var. Bordo) on Wistar rat tissues

Oliboni

Dani

Funchal³

et al. 2011

An. Acad. Bras. Ciênc.

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The purpose of this study was to evaluate the beneficial effects of organic and conventional grapevine (Vitis labrusca L.) leaf extracts in reducing hydrogen peroxide-induced stress in the liver, heart and kidney of Wistar rats by measuring lipids and proteins damages (carbonyl assay), as well as the activity of the antioxidant enzymes superoxide dismutase and catalase. The preincubation with 5 mg/mL of organic and conventional grapevine (Vitis labrusca L.) leaf extracts prevented both lipids and proteins oxidative damages in all tissues analyzed. The organic leaf extract was able to restore superoxide dismutase (kidney and liver) and catalase (heart) activities, which were modified by the treatment with H 2 O 2 . The conventional extract was able to restore only the catalase activity in liver and heart tissues. The beneficial effects of the V. labrusca leaf extract shown in this study could probably be important for formulating dietary supplements, as well as for developing new ingredients with improved antioxidant properties from other plant sources.

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“…A possible mechanism of Nyctanthes arbortristis ethanol extract as hepatoprotective may be due to its antioxidant effect which impairs the activation of carbon tetrachloride into the reactive form. Since flavonoides have hepatoprotective activities (Orhan et al, 2007). Tannins and carotenoids, both are known to be antioxidants with and hepatotoxic activity (Sasmal et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective activity of Nyctanthes arbor-tristis (l.)

Wagh¹,

Yeotkar²,

Nimbhorker³

et al. 2010

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe flowers of Nyctanthes arbor-tristis Linn. of Oleaceae widely used in Ayurvedic system of medicine for the treatment of diuresis, liver disorder, spleen enlargement sciatica, bitter, stomachic, carminative and tonic to hair. The aim of the present study was to evaluate the alcoholic and aqueous extracts of the flowers of Nyctanthes arbor-tristis for hepatoprotective effect against carbontetrachloride induced liver damage in rats. Administration of alcoholic and aqueous extracts of the leaves of Nyctanthes arbor-tristis protect the liver from toxic effects of carbontetrachloride by reducing the elevated levels of Serum glutamate pyruvate transaminase, Serum glutamate oxaloacetate transaminase, Alkaline phosphatase and serum bilirubin. Results revealed that both the alcoholic and aqueous extracts showed significant hepatoprotective activity by reducing the elevated levels of biochemical parameters at a dose of 200 mg/kg body weight. The results were supported by histopathological studies of liver samples which showed regeneration of hepatocytes by the extracts.

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Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachloride-induced acute liver damage in rats

Cited by 102 publications

References 21 publications

Evaluation of antioxidant activity of grapevine leaves extracts (Vitis labrusca) in liver of Wistar rats

Evaluation of antioxidant activity of grapevine leaves extracts (Vitis labrusca) in liver of Wistar rats

Hepatoprotective, cardioprotective, and renal-protective effects of organic and conventional grapevine leaf extracts (Vitis labrusca var. Bordo) on Wistar rat tissues

Hepatoprotective activity of Nyctanthes arbor-tristis (l.)

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