Hepatoprotective effect ofVitex negundo against carbon tetrachloride-induced liver damage

Abstract

Alcoholic extract of the seeds of Vitex negundo Linn. was obtained by cold maceration. A dose of 250 mg/kg (1/6 of LD50) of the extract was selected to study the hepatoprotective action against carbon tetrachloride-induced liver damage. The extract was found to be effective in preventing liver damage which was evident by morphological, biochemical and functional parameters.

Formulation and Evaluation of Novel Herbal Aerosol for Arthritis

“…It was reported for the presence phytochemical constituents, flavonoids such as casticin, orientin, isoorientin, luteolin, lutecin-7-O-glucoside, corymbosin; gardenins A and B [20]. VN has been documented for potent anti-inflammatory [21], anti-arthritic [22], anticonvulsant [23], hepatoprotective [24], laxative [25] and bronchial relaxant activities [26]. Though all parts of CH and VN are used, leaves are majorly used for treating arthritis in traditional medicine [27] and hence a dosage form was designed using the leaf extracts of the plants.…”

Protective effects ofPergularia daemiaroots against paracetamol and carbon tetrachloride-induced hepatotoxicity in rats

“…Hepatotoxicity causes loss in liver weight/100 g body weight of rats (Avadhoot & Rana, 1991;Bhanwra et al, 2000).…”

Negundoside, an irridiod glycoside from leaves of Vitex negundo , protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride

“…Regardless of its precise mechanism of action, numerous studies in various animal models and in humans describe protective effects of NG against oxidative stress-related disease states [2][3][4][5][6][7][8][9][10][11][12][13][14][15] . This enhances its potential usefulness as a preventive agent toward oxidative damage involved in the development of liver injury caused by oxidative stress.…”

“…It is a reputed medicinal herb and its parts have been employed as a traditional cure in Asian systems of medicine (Indian, Chinese, Malaysian) for a variety of disease conditions. A number of pharmacological activities have been attributed to V. negundo, such as: analgesic and anti-inflammatory activity [2] , enzymes inhibition [3] , nitric oxide scavenging activity [4] , snake venom neutralization activity [5] , antifeeding activity [6] , antiradical and antilipoperoxidative [7] , CNS activity [8] , hepatoprotective activity [9] , antibacterial activity [10] , anti-fungal [11] , larvicidal activity [12] , antiandrogenic effects [13] , mosquito repellent activity [14] . In the recent past, some of our work and work as reported by others on botanical products from V. negundo have shown a promising hepatoprotective activity [9,15] .…”