Protective effects of<i>Pergularia daemia</i>roots against paracetamol and carbon tetrachloride-induced hepatotoxicity in rats

Bhaskar, V. H.; Balakrishnan, N

doi:10.3109/13880201003730667

Cited by 20 publications

(9 citation statements)

References 29 publications

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“…The ethanolic extracts of aerial parts of P. daemia dose dependently prevented the paracetamol [ 133 ] and CCl 4 [ 134 , 135 ] induced biochemical (serum AST, ALT, APT, and TB) and histopathological changes in the liver. Recent studies on P. daemia showed significant anti-inflammatory, antioxidant, and free radical scavenging activities [ 132 – 134 ] which may also contribute to its hepatoprotective activity.…”

Section: Resultsmentioning

confidence: 99%

A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

Alasmari

Al-Elaiwi

Athar

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Liver disease is one of the major causes of morbidity and mortality across the world. According to WHO estimates, about 500 million people are living with chronic hepatitis infections resulting in the death of over one million people annually. Medicinal plants serve as a vital source of potentially useful new compounds for the development of effective therapy to combat liver problems. Moreover herbal products have the advantage of better affordability and acceptability, better compatibility with the human body, and minimal side effects and is easier to store. In this review attempt has been made to summarize the scientific data published on hepatoprotective plants used in Saudi Arabian traditional medicine. The information includes medicinal uses of the plants, distribution in Saudi Arabia, ethnopharmacological profile, possible mechanism of action, chemical constituents, and toxicity data. Comprehensive scientific studies on safety and efficacy of these plants can revitalise the treatment of liver diseases.

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Section: Resultsmentioning

confidence: 99%

A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

Alasmari

Al-Elaiwi

Athar

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…From ancient times, man has always used herbs for various liver disorders as a treatment strategy, because natural remedies from traditional medicinal plants have proven to be effective alternative treatments in cases of liver injury. From various studies, it has been found that hepatoprotective effects are directly associated with phytoconstituents (Sabir and Rocha, 2008;Choi et al, 2009;Bhaskar and Balakrishnan, 2010;Huang et al, 2010;Nayak et al, 2011;Rehman et al, 2012;Ibrahim et al, 2013). All around the world, and especially in developing countries, people use traditional herbal medicines; therefore, there is a strong need to develop such a hepatoprotective medicine using natural products that can pass the safety evaluation and screening in the early phase of drug discovery because most toxic compounds are metabolized in the liver (Iwalokun et al, 2006;Adeneye, 2009;Ajiboye et al, 2010;Ahmed et al, 2013;Chanda et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity

Hussain¹,

Ikram²,

Rehman³

et al. 2014

Turk J Biol

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Malva sylvestris is traditionally used for the treatment of liver diseases, but sufficient pharmacological-based scientific literature is not available online to authenticate its use in liver ailments. We aimed to assess the hepatoprotective effects of Malva sylvestris against paracetamol-induced hepatotoxicity in mice. The extract was concentrated using a rotary evaporator and then desired concentrations of extracts were made by dissolving in normal saline. The standard drug silymarin (100 mg/kg) was used as a reference drug to compare the therapeutic effects of Malva sylvestris. Two different doses of Malva sylvestris (300 and 600 mg/kg) were administered intraperitoneally for 7 consecutive days followed by intraperitoneal administration of paracetamol (250 mg/kg). Paracetamol significantly induced oxidative stress in the liver, ultimately leading to increased serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, and direct bilirubin. The extract of Malva sylvestris significantly reduced the serum levels of these elevated liver enzyme markers in a dose-dependent manner. Histopathological examination of liver tissues also showed hepatoprotective effects of Malva sylvestris in restoring normal functional ability of the liver. The results of our study strongly suggest that the extract of Malva sylvestris has strong hepatoprotective effects against paracetamol-induced liver injury, thereby scientifically affirming its traditional therapeutic role in liver injury.

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“…A substantial number of herbal formulations have been affirmed to have medicinal properties to cure several life-threatening diseases (Sabir and Rocha, 2008;Akash et al, 2011;Akash et al, 2014a,b;Bhaskar and Balakrishnan, 2010;Huang et al, 2010;Venkatesh et al, 2010;Nayak et al, 2011;Rehman et al, 2012;Ibrahim et al, 2013;Hussain et al, 2014;Parveen et al, 2014). The plants that exhibit hepatoprotective effects, have the phytoconstituents such as phenyl compounds, coumarins, essential oils, monoterpenoids, diterpenoids, triterpenoids, steroids, alkaloids and other nitrogenous compounds (Sharma et al, 2011;Valan et al, 2010) that reveal hepatoprotective effects by preventing the liver from the damaging effects of drug-induced intoxication .…”

Section: Discussionmentioning

confidence: 99%