Hepatoprotective Effects of Acalypha Indica and Centella Asiatica in Rat's Liver Against Hypoxia

Dwijayanti, Adisti; Frethernety, Agnes; Hardiany, Novi Silvia; Purwaningsih, Erni Hernawati

doi:10.1016/j.proche.2015.03.003

Cited by 10 publications

(5 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diuretics lower limbic pressure and deplete body sodium stores, diuretics lower blood pressure by decreasing blood volume and cardiac output, vascular and peripheral resistance. Deuresis will decrease plasma volume and stroke volume which will decrease cardiac output which ultimately lowers blood pressure (12). This shows that blood pressure is reduced after administration of avocado therapy.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Giving Avocado Leaf Boiled Water on Lowering Blood Pressure in the Elderly with Hypertension in the Work Area Gambut Health Center

Mar'iyah¹,

Rohman²,

Fajar³

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Hypertension is a condition of a person's blood pressure being at a level above normal, hypertension treatment can be done herbally using avocado leaves. Avocado leaves can lower blood pressure because they contain active substances, namely flavonoids and quercetin. This research was conducted in the working area of the Tilango Health Center. Objective: This study aims to determine the effect of giving boiled water of avocado leaves on reducing blood pressure in the elderly with hypertension. Methods: Design This study used a two-group quasi-experimental pre-test - post-test design. The sample is the elderly who have hypertension, amounting to 125 people with purposive sampling technique. The research instrument used a questionnaire. Results: Statistical test using T-Test on blood pressure before and after the intervention was given a significance value of 0.000 (p-value < 0.05 ). Conclusion : This study concludes that there is a significant effect between giving avocado leaf boiled water on reducing blood pressure in the elderly with hypertension in the working area of the Tilango Health Center.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effect of Giving Avocado Leaf Boiled Water on Lowering Blood Pressure in the Elderly with Hypertension in the Work Area Gambut Health Center

Mar'iyah¹,

Rohman²,

Fajar³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Diuretik menurunkan tekanan limbik mendeplesikan simpanan natrium tubuh, diuretik menurunkan tekanan darah dengan menurunkan volume darah dan curah jantung, tahanan vaskuler dan periver. Deuresis akan menurunkan volume plasma dan stroke volume yang akan menurunkan curah jantung yang akhirnya menurunkan tekanan darah (12). Hal ini menunjukkan bahwa tekanan darah berkurang sesudah pemberian terapi alpukat.…”

Section: Pembahasanunclassified

Pengaruh Pemberian Air Rebusan Daun Alpukat Terhadap Penurunan Tekanan Darah pada Lansia dengan Hipertensi di Wilayah Kerja Puskesmas Tilango

Ishak

Nurdin

2022

J mppki

View full text Add to dashboard Cite

Latar Belakang: Hipertensi merupakan suatu keadaan tekanan darah seseorang berada pada tingkatan di atas normal, pengobatan hipertensi dapat dilakukan secara herbal yaitu menggunakan daun alpukat. Daun alpukat bisa menurunkan tekanan darah karena adanya kandungan zat aktif yaitu flavonoid dan quersetin. Penelitian ini dilakukan di wilayah kerja Puskesmas Tilango. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian air rebusan daun alpukat terhadap penurunan tekanan darah pada lansia dengan hipertensi. Metode: Desain Penelitian ini menggunakan two group quasi eksperiment pre test - post test design. Sampel adalah lansia yang mengalami hipertensi yang berjumlah 130 orang dengan tekhnik purposive sampling. Instrumen penelitian ini mengunakan Kuesioner. Hasil: Uji statistik menggunakan T-Test terhadap tekanan darah sebelum dan sesudah diberikan intervensi yang didapatkan nilai significancy 0,000 (p-value <0,05). Kesimpulan: Penelitian ini menyimpulkan bahwa terdapat pengaruh yang bermakna antara pemberian air rebusan daun alpukat terhadap penurunan tekanan darah pada lansia dengan hipertensi di wilayah kerja Puskesmas Tilango.

show abstract

“…Liver slices of 60mg weight were kept in icy-cold Phosphate buffer (0.2 M) at pH 7.4 containing 30μg BSP/ml at 38°C. The concentration of Bromosulphalein was determined at 580 nm spectrophotometrically (SHIMADZU 1800) 16,17 .…”

Section: In-vitro Bromsulphalein (Bsp) Uptake Testmentioning

confidence: 99%

Untitled

2022

IJPSR

View full text Add to dashboard Cite

Rungia parviflora belongs to the family Acanthaceae (Linn.). The dried and powdered leaves were extracted with ethanol in Soxhlet's apparatus for 12 hrs. The extract was subjected to toxicity studies at the doses of 5, 50, 300, and 2000 mg/kg under the observation of 24 hrs. An acute toxicity study of ethanolic extract was found to be toxic (1/2 of rats died) at a dose of 2000 mg/kg, orally. Hence, it was taken as LD 50 . Further, the hepatoprotective activity of Ethanolic extract at the dose level of 250mg/kg and 500 mg/kg ware studied in Wistar male rats against thioacetamide (400mg/kg p.o.) induced hepatotoxicity. Silymarin 100mg/kg p.o. was taken as a standard hepatoprotective drug. The hepatoprotective activity was studied by determining the parameters like SGPT, SGOT, Total Bilirubin, ALT, Pentobarbitone induced sleeping time, Ascorbic acid content in urine, in-vitro Bromsulphalein uptake test and Histopathological observation of liver. Overall study indicated that ethanolic extract of leaves of Rungia parviflora at a dose level of 250mg/kg and 500mg/kg significantly protects the liver against hepatotoxicity induced by thioacetamide. INTRODUCTION:Medicinal uses of many plants are yet scientifically proven even though their traditional uses have been mentioned for years. One of such plants, Rungia parviflora belongs to the family Acanthaceae. Traditionally it is used as aperient, febrifuge, Refrigerant, smallpox 1 as six spoonfuls of plant juice is taken three times a day 2 . The leaves are rubbed and extracted juice is applied to the wound and cut externally 3 .

show abstract

Hepatoprotective Effects of Acalypha Indica and Centella Asiatica in Rat's Liver Against Hypoxia

Cited by 10 publications

References 3 publications

<em>The Effect of Giving Avocado Leaf Boiled Water on Lowering Blood Pressure in the Elderly with</em> <em>Hypertension in the Work Area Gambut Health Center</em>

<em>The Effect of Giving Avocado Leaf Boiled Water on Lowering Blood Pressure in the Elderly with</em> <em>Hypertension in the Work Area Gambut Health Center</em>

Pengaruh Pemberian Air Rebusan Daun Alpukat Terhadap Penurunan Tekanan Darah pada Lansia dengan Hipertensi di Wilayah Kerja Puskesmas Tilango

Untitled

Contact Info

Product

Resources

About