Hepatoprotective effects of Adenanthera pavonina (Linn.) against anti-tubercular drugs-induced hepatotoxicity in rats

Mujahid, Md.; Siddiqui, Hefazat Hussain; Hussain, Arshad; Hussain, Md. Sarfaraj

doi:10.1016/j.phcgj.2013.08.003

Cited by 26 publications

(22 citation statements)

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“…INH and RIF (50 mg/kg body weight each, p.o.) for 28 days to produce hepatotoxicity [13], while group III (MEEI 100) and IV (MEEI 200) received orally 100 and 200 mg/kg body weight of E. indica for 28 days, prior to antitubercular drugs challenge as per group II. Group V received Silymarin (standard) the known hepatoprotective compound at a dose of 100 mg/kg, p.o., daily for 28 days, prior to antitubercular drugs challenge as per group II.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of hepatoprotective potential of Erythrina indica leaves against antitubercular drugs induced hepatotoxicity in experimental rats

Mujahid

Hussain

Siddiqui

et al. 2017

Journal of Ayurveda and Integrative Medicine

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BackgroundErythrina indica Lam. traditionally used in the treatment of laxative, diuretic, worm infestation, liver ailment and joints pain.ObjectiveTo evaluate the antihepatotoxic potential of Erythrina indica against isoniazid (INH) and rifampicin (RIF) induced hepatotoxicity in rats.Methods and materialLiver toxicity was induced by antitubercular drugs (INH+ RIF) at dose level of 50 mg/kg each, p.o for 28 days. 50% methanolic extract of Erythrina indica (100 and 200 mg/kg) were administered orally once daily for 28 days. The hepatoprotective activity was assessed using various biochemical parameters SGOT, SGPT, ALP, bilirubin, total protein, albumin and LDH. Meanwhile, in vivo antioxidant activities as SOD, CAT, GSH and, LPO were measured in liver homogenate also histological examinations were carried out to assess hepatoprotective activity.Statistical analysis usedThe values were subjected to one way analysis of variance (ANOVA) followed by Tukey multiple compare test. Results were considered statistically significant when P < 0.05.ResultsObtained results demonstrated that the treatment with Erythrina indica (E. indica) significantly prevented drug induced increase in serum levels of hepatic enzymes. Furthermore, Erythrina indica significantly reduced the lipid peroxidation (P < 0.01 tp P < 0.001) in the liver tissue and restored activities of defense antioxidant enzymes GSH (2.15 ± 0.08 to 2.48 ± 0.99; P < 0.05), SOD (2.69 ± 0.752 to 3.712 ± 0.056; P < 0.05 to P < 0.01) and CAT (10.20 ± 0.58 to 12.59 ± 0.42; P < 0.05 to P < 0.001) towards normal. Histopathology of liver tissue showed that Erythrina indica attenuated the hepatocellular necrosis, regeneration and repair of cells toward normal.ConclusionThe results of this study strongly indicate the protective effect of Erythrina indica against liver injury which may be attributed to its hepatoprotective activity, and there by scientifically support its traditional use.

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Section: Methodsmentioning

confidence: 99%

Evaluation of hepatoprotective potential of Erythrina indica leaves against antitubercular drugs induced hepatotoxicity in experimental rats

Mujahid

Hussain

Siddiqui

et al. 2017

Journal of Ayurveda and Integrative Medicine

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“…Group II served as an acute toxic control and received 12 mL/kg orally (po) 50% ethanol orally throughout the study. Groups III–VI received 400 mg/kg po of different bark extracts of S. pinnata orally, and Group VII received standard drug silymarin, 100 mg/kg/d po 15 . All groups of animals were administered 12 mL/kg po of 50% ethanol after 2 hours pretreatment each day, except rats in the normal control group, for 8 consecutive days 16 .…”

Section: Methodsmentioning

confidence: 99%

Protection of hepatotoxicity using Spondias pinnata by prevention of ethanol-induced oxidative stress, DNA-damage and altered biochemical markers in Wistar rats

Iqbal¹,

Mujahid²,

Khalid³

et al. 2016

Integrative Medicine Research

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BackgroundTraditional systems of medicine use herbal drugs for hepatoprotection. Thus, the study was designed to evaluate the hepatoprotective and antioxidant effects of Spondias pinnata bark extracts against ethanol-induced liver injury in Wistar rats.MethodsGroup I animals were treated with 1 mL/kg 0.3% carboxymethyl cellulose and Group II with 12 mL/kg 50% ethanol for 8 consecutive days. Groups III–VII animals were first treated with 400 mg/kg petroleum ether extract, chloroform extract, acetone extract (AE), ethanol extract (EE), and 100 mg/kg silymarin, and then 12 mL/kg 50% ethanol orally after 2 hours pretreatment each day for 8 consecutive days. Six hours after the last dose, blood was withdrawn. The hepatoprotective activity was assessed by several biochemical and antioxidant parameters. It was accomplished by the histopathology and DNA fragmentation study of liver tissues.ResultsTreatment with S. pinnata extracts, mainly AE and EE significantly (p < 0.05–0.01) and dose-dependently prevented the ethanol-induced increase in serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, cholesterol, bilirubin, and malondialdehyde, and decrease in reduced glutathione, catalase, superoxide dismutase, and albumin. They also attenuated the ethanol-induced DNA damage. Hepatoprotective potential of the extract was less than that of standard drug silymarin. Results of the study were well supported by the histopathological observations.ConclusionS. pinnata extracts AE and EE possess a potent hepatoprotective effect against ethanol-induced liver injury in Wistar rats, and protect them from hepatotoxicity by prevention of ethanol-induced oxidative stress, DNA-damage and altered biochemical markers.

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“…In addition, INH and RIF's administration resulted in hepatic apoptosis; it significantly increased the level of hepatic malondialdehyde and caused glutathione (GSH) depletion. From an earlier study, it is evident that hydrazine, which is the metabolite of INH 33 plays a crucial role in INH-induced liver damage in rats, and the combination of INH and RIF was reported as higher rate of biliary secretion, an increase in liver cell LPO and cytochrome P450 was thought to be involved in the synergistic effects of RIF on INH [22] . In another experiment, where the rats were treated with INH and RIF intra-gastrically, the result was hepatic injury with altered lipid metabolism and lipid profiles [23] .…”

Section: Discussionmentioning

confidence: 99%

Reparation of Isoniazid and Rifampicin Combinatorial Therapy-Induced Hepatotoxic Effects by <b><i>Bacopa monnieri</i></b>

Sabina

Udhaya²,

Sunitha³

et al. 2016

Pharmacology

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Drug-induced liver injury is a major challenge in treating tuberculosis with isoniazid (INH) and rifampicin (RIF). This study was aimed at evaluating the protective effects of Bacopamonnieri (Brahmi) against INH and RIF-induced hepatotoxicity in a rat model and also to study the patterns of interaction between pregnane X receptor (PXR) and chosen active compounds of B. monnieri. Hepatotoxicity was induced in the experimental animals by the oral administration of INH and RIF (50 mg/kg b.w. each/day) for 28 days. The effects of co-administration of B. monnieri (500 mg/kg b.w./day) in INH- and RIF-induced rats were studied by the estimation of biochemical analyses. The standard hepatoprotective drug silymarin (25 mg/kg b.w./day) was used for the purpose of comparison. In silico docking experiments were carried out using the PatchDock server and the results were analysed on the PyMol molecular viewer. There was significant reduction in the antioxidant status of INH and RIF-induced rats. Also, there was significant elevation in the levels of serum liver function markers in the INH- and RIF-induced rats. B. monnieri was able to normalise the tested parameters. In silico studies reveal significant interaction between PXR and bacopaside I. B. monnieri exerts significant protective effects against INH and RIF-induced hepatotoxicity in rats.

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Hepatoprotective effects of Adenanthera pavonina (Linn.) against anti-tubercular drugs-induced hepatotoxicity in rats

Cited by 26 publications

References 13 publications

Evaluation of hepatoprotective potential of Erythrina indica leaves against antitubercular drugs induced hepatotoxicity in experimental rats

Evaluation of hepatoprotective potential of Erythrina indica leaves against antitubercular drugs induced hepatotoxicity in experimental rats

Protection of hepatotoxicity using Spondias pinnata by prevention of ethanol-induced oxidative stress, DNA-damage and altered biochemical markers in Wistar rats

Reparation of Isoniazid and Rifampicin Combinatorial Therapy-Induced Hepatotoxic Effects by <b><i>Bacopa monnieri</i></b>

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