Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury

Huang, Guan Jhong; Deng, Jeng Shyan; Huang, Szu-Wei; Lee, Chao Ying; Hou, Wen Chi; Wang, Sheng-Yang; Sung, Ping Jyun; Kuo, Yueh Hsiung

doi:10.1016/j.foodchem.2013.03.061

Cited by 67 publications

(59 citation statements)

References 27 publications

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“…These radicals initiate lipid peroxidation and necrosis of the liver. Trichloromethyl radicals also impair the cellular antioxidant capacity by deactivating GSH and other antioxidant enzymes (Sahreen et al, 2011;Khan et al, 2012;Huang et al, 2013). In the present investigation, we did not determine a mechanism for how Zn suppresses lethal toxicity induced by CCl 4 , but postulate that this protection is mediated, at least in part, by MT induction.…”

Section: Hepatic Protective Effect On Zn Against Acute CCL 4 Toxicitymentioning

confidence: 56%

Carbon tetrachloride-induced lethality in mouse is prevented by multiple pretreatment with zinc sulfate

et al. 2016

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-Carbon tetrachloride (CCl 4 ) is commonly used as a chemical inducer of experimental liver injury. Several compounds have been demonstrated to attenuate the hepatic damage caused by sublethal doses of CCl 4 . However, rescue from lethal toxicity of CCl 4 has not been reported. In the present study, we evaluated the protective effect of metallothionein (MT), an endogenous scavenger of free radicals, on CCl 4 -induced lethal toxicity of mice. To induce MT production in male ddY mice, we administered Zn (as ZnSO 4 ) at 50 mg/kg as a once-daily subcutaneous injection for 3 days prior to a single intraperitoneal administration of 4 g/kg CCl 4 . Animals were observed for mortality every 3 hr for 24 hr after CCl 4 injection. Liver damage was assessed by determining (in a subset of these mice) blood levels of alanine aminotransferase (ALT; a marker of liver injury) and liver histopathology at 6 hr after CCl 4 injection. Our results showed that three times pretreatment with Zn yielded > 40-fold induction of hepatic MT protein levels compared to control group. Zn pretreatment completely abolished the CCl 4 -induced mortality of mice. We also found that pretreatment of mice with Zn significantly decreased the ALT levels and reduced the histological liver damage as assessed at 6 hr post-CCl 4 . These findings suggest that prophylaxis with Zn protects mice from CCl 4 -induced acute hepatic toxicity and mortality, presumably by induction of radical-scavenging MT.

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Section: Hepatic Protective Effect On Zn Against Acute CCL 4 Toxicitymentioning

confidence: 56%

Carbon tetrachloride-induced lethality in mouse is prevented by multiple pretreatment with zinc sulfate

et al. 2016

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“…The ROS induced by CCl 4 causes direct tissue damage, and initiates inflammation through the activation of various cytokines. 9) Several studies have shown how some compounds show protective effects against CCl 4 -induced hepatotoxicity. [7][8][9][10] Some of these compounds attenuated oxidative stress and the inflammatory response.…”

Section: +mentioning

confidence: 99%

“…9) Several studies have shown how some compounds show protective effects against CCl 4 -induced hepatotoxicity. [7][8][9][10] Some of these compounds attenuated oxidative stress and the inflammatory response. 10) As JTX modulates the immune system, such as Toll-like receptor 4 signaling pathways, 25,26) it might also suppress the inflammatory response activated by CCl 4 .…”

Section: +mentioning

confidence: 99%

“…In addition, associated protective mechanisms possibly act on each of the five steps. [7][8][9][10] The Japanese herbal medicine "Juzen-taiho-to" (JTX) is a Kampo medicinal prescription, and has been used historically in Japan for the treatment of cancers, rheumatoid arthritis, and atopic dermatitis. 11) JTX is consisting of ten medicinal herbs in the indicated amounts (g per day in human intake);…”

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confidence: 99%

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Suppressive Effect of Kampo Formula “Juzen-taiho-to” on Carbon Tetrachloride-Induced Hepatotoxicity in Mice

Yoshioka

Fukaya

Miura

et al. 2016

Biological & Pharmaceutical Bulletin

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“…Through these steps, necrosis is induced; this induction is termed as the fifth step. Multiple compounds have been reported to show protective effects against CCl 4 -induced hepatotoxicity, and associated protective mechanisms have been proposed to act on each of the five steps [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Kampo formula “Hochu-ekki-to” suppressed carbon tetrachloride-induced hepatotoxicity in mice

Yoshioka

Fukaya

Onosaka

et al. 2016

Environ Health Prev Med

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Objective The aim of this study was to investigate whether pretreatment with the Japanese herbal medicine ''Hochuekki-to'' (TJ-41) has an ameliorative effect on carbon tetrachloride (CCl 4 )-induced hepatotoxicity through anorexia prevention. Methods Twenty-four hours before CCl 4 injection, TJ-41 or saline solution was intraperitoneally administered. Furthermore, 24 h after TJ-41 injection, mice were intraperitoneally administered 1.6 g/kg CCl 4 or olive oil. Moreover, 24 h after CCl 4 /olive oil injection, mice from each group were euthanized and bled for plasma analysis. Results Mice injected with CCl 4 exhibited severe anorexia. Moreover, CCl 4 increased the plasma levels of hepatic injury markers (i.e., alanine aminotransferase and aspartate aminotransferase) as well as lipid peroxidation and hepatic Ca levels. Pretreatment with TJ-41 recovered the CCl 4 -induced anorexia and plasma levels of the hepatic injury markers. Moreover, CCl 4 -induced lipid peroxidation and hepatic Ca levels decreased upon TJ-41 pretreatment. In addition, hepatic metallothionein levels in the TJ-41 ? CCl 4 -treated group were decreased by [50 % compared with the levels in the TJ-41-treated group, implying that metallothionein was consumed by CCl 4 -induced radicals. ConclusionOur results suggest that TJ-41 attenuates CCl 4 -induced hepatotoxicity, presumably by the induction of metallothionein, which in turn scavenges radicals induced by CCl 4 exposure.

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Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury

Cited by 67 publications

References 27 publications

Carbon tetrachloride-induced lethality in mouse is prevented by multiple pretreatment with zinc sulfate

Carbon tetrachloride-induced lethality in mouse is prevented by multiple pretreatment with zinc sulfate

Suppressive Effect of Kampo Formula “Juzen-taiho-to” on Carbon Tetrachloride-Induced Hepatotoxicity in Mice

Kampo formula “Hochu-ekki-to” suppressed carbon tetrachloride-induced hepatotoxicity in mice

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