Hepatoprotective effects of<i>Ficus racemosa</i>stem bark against carbon tetrachloride-induced hepatic damage in albino rats

Ahmed, Faiyaz; Urooj, Asna

doi:10.3109/13880200903081788

Cited by 19 publications

(9 citation statements)

References 30 publications

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“…was administered. Data are mean ± SD *Different from control, p < 0.05; **different from rats receiving CCl 4 alone, p < 0.05. generated due to the metabolic transformation of CCl 4 in the liver or by the interruption of the lipid peroxidation progression (Ahmed & Urooj, 2010). This protection is of similar magnitude to the effects of NAC, a well-known and potent antioxidant.…”

Section: In Vivo Assaymentioning

confidence: 99%

Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract ofCecropia glaziovii(embaúba-vermelha) against acyclovir-resistant strain

Petronilho¹,

Costa²,

Kappel³

et al. 2012

Pharmaceutical Biology

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Section: In Vivo Assaymentioning

confidence: 99%

Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract ofCecropia glaziovii(embaúba-vermelha) against acyclovir-resistant strain

Petronilho¹,

Costa²,

Kappel³

et al. 2012

Pharmaceutical Biology

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“…[10–13] We have also reported F. racemosa bark extract to exhibit potential hepatoprotective activity against CCl 4 -induced hepatotoxicity and cardioprotective effect against doxorubucin-induced cardiotoxicity in rats. [1415] In view of this, the present study evaluated the protective effects of standardized extract of F. racemosa stem bark against doxorubicin-induced renal and testicular toxicity in albino rats.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of Ficus racemosa stem bark against doxorubucin-induced renal and testicular toxicity

2013

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Background:Ficus racemosa Linn. (Moraceae) bark is a rich source of phenolic compounds known to possess potential antioxidant activity offering numerous health benefits.Materials and Methods:The present study evaluated the protective effects of sequential acetone extract of Ficus racemosa bark at two doses (FR250; 250 mg kg-1 and FR500; 500 mg kg-1 p.o.) against doxorubicin-induced renal and testicular toxicity in rats.Results:Doxorubicin administration resulted in significant decrease (P ≤ 0.05) in total protein and glutathione concentrations, while increased (P ≤ 0.05) serum urea, creatinine and thiobarbituric acid reactive substances (TBARS). Extract pretreatment restored biochemical parameters toward normalization. FR250 and FR500 decreased serum creatinine levels by 22.5% and 44%, while serum urea levels were decreased by 30.4% and 58.8%, respectively. Extract pretreatment (500 mg kg-1) decreased TBARS and increased glutathione levels in the kidney and testis to control levels. These observations were substantiated by histopathological studies, wherein normal renal and testicular architecture was restored in FR500 group.Conclusion:Doxorubicin exposure results in pronounced oxidative stress, and administration of F. racemosa stem bark extract offers significant renal and testicular protection by inhibiting lipidperoxidation-mediated through scavenging free radicals.

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“…Further, it has also exhibited significant TBARS lowering and glutathione restoration effect in streptozotocin-induced diabetic rats (Ahmed & Urooj, 2009b). We have also reported F. racemosa stem bark to exhibit potential hepatoprotective effect against CCl 4 -induced hepatotoxicity in rats (Ahmed & Urooj, 2010).…”

Section: Research Articlementioning

confidence: 81%

Cardioprotective activity of standardized extract ofFicus racemosastem bark against doxorubicin-induced toxicity

Ahmed

Urooj

2011

Pharmaceutical Biology

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Hepatoprotective effects ofFicus racemosastem bark against carbon tetrachloride-induced hepatic damage in albino rats

Cited by 19 publications

References 30 publications

Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract ofCecropia glaziovii(embaúba-vermelha) against acyclovir-resistant strain

Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract ofCecropia glaziovii(embaúba-vermelha) against acyclovir-resistant strain

Protective effects of Ficus racemosa stem bark against doxorubucin-induced renal and testicular toxicity

Cardioprotective activity of standardized extract ofFicus racemosastem bark against doxorubicin-induced toxicity

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