Hepatoprotective effects of &lt;i&gt;Sapium sebiferum&lt;/i&gt; in paracetamol-induced liver injury

Hussain, Liaqat; Akash, Muhammad Sajid Hamid; Tahir, Madeha; Rehman, Kanwal

doi:10.3329/bjp.v10i2.22576

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…These have been found to exert a diverse range of protective effects that mitigate the devastating neurodegeneration [ 15 ]. Generally, plant species with antioxidant properties have been broadly recognized to ameliorate the disease process [ 16 – 19 ]. P .…”

Section: Introductionmentioning

confidence: 99%

“…ese have been found to exert a diverse range of protective effects that mitigate the devastating neurodegeneration [15]. Generally, plant species with antioxidant properties have been broadly recognized to ameliorate the disease process [16][17][18][19]. P. armeniaca L. contains various flavonoids such as quercetin, a potent antioxidant that has been credited to protect neurons from free radical-associated cellular degeneration in PD [20].…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model

Saleem

Hussain

Shahid

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Parkinson’s disease (PD) is a complex, age-related neurodegenerative disease that causes neuronal loss and dysfunction over time. An imbalance of redox potential of oxidative stress in the cell causes neurodegenerative diseases and dysfunction of neurons. Plants are a rich source of bioactive substances that attenuate oxidative stress in a variety of neurological disorders. The aim of the present study was to evaluate the Prunus armeniaca L. methanolic extract (PAME) for anti-Parkinson activity in rats. PD was induced with haloperidol (1 mg/kg, IP). The PAME was administered orally at 100, 300, and 800 mg/kg dose levels for 21 days. Behavioral studies (catalepsy test, hang test, open-field test, narrow beam walk, and hole-board test), oxidative stress biomarkers (SOD, CAT, GSH, and MDA) levels, neurotransmitters (dopamine, serotonin, and noradrenaline) levels, and acetylcholinesterase activity were quantified in the brain homogenate. Liver function tests (LFTs), renal function tests (RFTs), complete blood count (CBC), and lipid profiles were measured in the blood/serum samples to note the side effects of PAME at the selected doses. Histopathological analysis was performed on the brain (anti-PD study), liver, heart, and kidney (to check the toxicity of PAME on these vital organs). Motor functions were improved in the behavioral studies. Dopamine, serotonin, and noradrenaline levels were significantly increased ( P < 0.001 ), whereas the level of acetylcholinesterase was decreased significantly ( P < 0.001 ). The levels of superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) were increased, while malondialdehyde (MDA) and nitrite levels were decreased in the PAME-treated groups significantly compared with the disease control group, hence reducing oxidative stress. The incidence of toxicity was determined by biochemical analysis of LFT and RFT biomarkers testing. The histopathological analysis indicated that neurofibrillary tangles and plaques decreased in a dose-dependent manner in the PAME-treated groups. Based on the data, it is concluded that PAME possessed good anti-Parkinson activity, rationalizing the plant’s traditional use as a neuroprotective agent.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model

Saleem

Hussain

Shahid

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Leaves of Sapium sebiferum (L.) Roxb (Euphorbiaceae) (Hussain et al. 2015 ) and Malva sylvestris L. (Malvaceae) (Hussain et al. 2014 ) showed strong hepatoprotective effects against paracetamol-induced liver injury.…”

Section: Introductionmentioning

confidence: 99%

GC-MS analysis and hepatoprotective activity of the n -hexane extract of Acrocarpus fraxinifolius leaves against paracetamol-induced hepatotoxicity in male albino rats

El-Ghffar

El-Nashar

Eldahshan

et al. 2016

Pharmaceutical Biology

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Context: In Egypt, the burden of liver diseases is exceptionally high.Objective: To investigate the components of the n-hexane extract of Acrocarpus fraxinifolius Arn. (Leguminosae) and its hepatoprotective activity against paracetamol (APAP)-induced hepatotoxicity in rats.Material and methods: TRACE GC ultra gas chromatogaphic spectrometry was used for extract analysis. Thirty albino rats were divided into six groups (five rats in each). Group 1 was the healthy control; Groups 2 and 3 were healthy treated groups (250 and 500 mg/kg b.w. of the extract, respectively) for seven days. Group 4 was hepatotoxicity control (APAP intoxicated group). Groups 5 and 6 received APAP + extract 250 and APAP + extract 500, respectively.Results: Chromatographic analysis revealed the presence of 36 components. Major compounds were α-tocopherol (18.23%), labda-8 (20)-13-dien-15-oic acid (13.15%), lupeol (11.93%), phytol (10.95%) and squalene (7.19%). In the acute oral toxicity study, the mortality rates and behavioural signs of toxicity were zero in all groups (doses from 0 to 5 g/kg b.w. of A. fraxinifolius). LD50 was found to be greater than 5 g/kg of the extract. Only the high dose (500 mg/kg b.w.) of extract significantly alleviated the liver relative weight (4.01 ± 0.06) and biomarkers, as serum aspartate aminotransferase (62.87 ± 1.41), alanine aminotransferase (46.74 ± 1.45), alkaline phosphatase (65.96 ± 0.74), lipid profiles (180.39 ± 3.51), bilirubin profiles (2.30 ± 0.06) and hepatic lipid peroxidation (114.20 ± 2.06), and increased body weight (11.58 ± 0.20), serum protein profile (11.09 ± 0.46) and hepatic total antioxidant capacity (23.78 ± 0.66) in APAP-induced hepatotoxicity in rats.Conclusion: Our study proves the antihepatotoxic/antioxidant efficacies of A. fraxinifolius hexane extract.

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Anti-inflammatory mechanism and active ingredients of the Chinese tallow tree

Chen

Guo

2020

Journal of Ethnopharmacology

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Hepatoprotective effects of <i>Sapium sebiferum</i> in paracetamol-induced liver injury

Cited by 4 publications

References 24 publications

Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model

Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model

GC-MS analysis and hepatoprotective activity of the n -hexane extract of Acrocarpus fraxinifolius leaves against paracetamol-induced hepatotoxicity in male albino rats

Anti-inflammatory mechanism and active ingredients of the Chinese tallow tree

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