Hepatoprotective potential and chemical characterization of Artocarpus lakoocha fruit extract

Saleem, Mohammad; Asif, Ammara; Akhtar, Muhammad Furqan; Saleem, Ammara

doi:10.3329/bjp.v13i1.34117

Cited by 14 publications

(15 citation statements)

References 10 publications

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“…Liver is the major organ which plays a key roles in processing of critical biochemical and physiological phenomena including metabolism and detoxification of endogen and exogenous compounds, such as drugs and xenobiotics, homeostasis, growth, energy and nutrient supply [1,2]. Hepatic injury could be occurred by hepatotoxic agents including drugs, alcohol and viral infections [3]. Liver diseases like jaundice, cirrhosis and fatty liver have been public health concern across the world.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Liver Protective Activity of Moringa oleifera Bark Extract in Paracetamol Induced Hepatotoxicity in Rats

Islam

Alam

Shanta

et al. 2019

JPRI

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Background: Moringa oleifera has been used in folk medicine to alleviate several diseases. In the present study, ethanolic extract of Moringa oleifera bark has been investigated to study its potential on paracetamol induced hepatotoxicity on model rats. Methods: Rats (150–200 gm) were divided into 5 groups containing 6 animals each. Acute hepatotoxicity was induced by paracetamol (600 mg/kg body weight) administered once daily for one week whereas the extract of investigated plant was given orally throughout the whole experiment at 250 and 500 mg/kg body weight. Silymarin (100 mg/kg body weight) was given orally as standard hepatoprotective drug. The level of hepatic injury recovery was determined by the estimation of liver enzymes like SGPT, SGOT, ALP, Bilirubin, Total protein, globulin and Albumin. Results: Treatment with MO extract as well as standard hepatoprotective agent silymarin ameliorated plasma levels of hepatic enzymes. Body weight was improved significantly by MO extracts (p < 0.01), whereas liver weight was recovered insignificantly. SGPT, SGOT and ALP levels were improved very highly significantly (p<0.001) and highly significantly (p<0.01) at MO 250mg dose. While at the dose of 500 mg/kg ameliorated SGPT Level very highly significantly (p<0.001), SGOT Level highly significantly (p<0.01) but insignificant to ALP level. Conclusion: The biochemical parameters provide evidence that the ethanolic extract of of Moringa oleifera bark has shown hepatoprotective activity.

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Section: Introductionmentioning

confidence: 99%

“…Moreover they can have serious side effects [5]. Due to the fact, a huge number of medicinal plants have been trialed to figure out regenerative and hepatoprotective activity [3]. Approximately 160 phytochemical constituents originated from 101 plants have been reported to be potentially hepatoprotective [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Liver Protective Activity of Moringa oleifera Bark Extract in Paracetamol Induced Hepatotoxicity in Rats

Islam

Alam

Shanta

et al. 2019

JPRI

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“…Liver is the major organ which plays a key roles in processing critical biochemical and physiological phenomena including metabolism and Detoxification of endogen and exogenous compounds, such as drugs and xenobiotics, homeostasis, growth, energy and nutrient supply [1,2 ] Hepatic injury could be occurred by hepatotoxic agents including drugs , alcohol and viral infections. [ 1,3 ]Liver diseases like jaundice, cirrhosis and fatty liver have been public health concern across the world. Prevalence of chronic liver disease worldwide is 18 Deoxy-niazimicine [ 10,11,12] A great number of pharmacological activity has also been reported .Aqueous and alcoholic extracts of leaves and roots of Moringa oleifera has been reported to have a strong in-vitro anti-oxidant and radical scavenging activity [12] while Methanolic and ethanolic extract of leaves against pentylenetetrazole and maximal electroshock induced convulsions, demontrated significant anti-convulsant activity [13,14] Potent antidiabetic activity from different extracts of leaves , seed and pod, has also been reported [ ,15,16, 17] an investigation against seed power also revealed its Anti-asthmatic activity [ 19,18] Study on Ethanolic extracts of Moringa oleifera exhibited potent anti-tumor [ 19] and Anthelmintic activity [21 , 22] Another study of alcoholic extracts of leaves as well as seeds has showed effectiveness on isoniazid, rifampicin, and pyrizinamide induced liver damage.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of liver protective activity ofMoringa oleiferabark extract in paracetamol induced hepatotoxicity in rats

Islam

Alam

2019

Preprint

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Background: Moringa oleifera has been used in folk medicine to alleviate several diseases. In the present study, ethanolic extract of Moringa oleifera bark has been investigated to study its potential on paracetamol induced hepatotoxicity on model rats. Methods: Rats (150to 200 gm) were divided into 5 groups containing 6 animals each. Acute hepatotoxicity was induced by paracetamol (600 mg/kg body weight) administered once daily for one week whereas the extract of investigated plant was given orally throughout the whole experiment at 250 and 500mg/kg body weight. Silymarin (100mg/kg body weight) was given orally as standard hepatoprotective drug. The level of hepatic injury recovery was determined by the estimation of liver enzymes like SGPT, SGOT, ALP, Bilirubin, Total protein and Albumin. Results: Treatment with MO extract as well as standard hepatoprotective agent silymarin ameliorated the increased plasma levels of these hepatic enzymes and indicated the hepatoprotective potential of the extract. Conclusion: The biochemical parameters provide evidence that the ethanolic extract of of Moringa oleifera bark has shown hepatoprotective activity.

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“…and the extracts were given orally using oral gavage. Since most studies used 100-500 mg extract per kg of body weight [22][23][24], the dose of 250 mg/kg was, therefore, selected for this study. The body weights (in grams) of the rats were recorded biweekly for six weeks of the experiment.…”

Section: (D) Induction Of Fibrosismentioning

confidence: 99%

Anti-fibrotic effects of polygonum plebeium r.br. in CCl4-induced hepatic damage and fibrosis in rats

et al. 2018

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Introduction: Asian countries have the highest burden of liver diseases. Polygonum plebeium (P. plebeium), a.k.a. the common knotweed, is a species of plant in the knotwood family that can act as a blood purifier and has been widely used in Pakistan to cure liver disorders like jaundice and hepatitis. The plant is also used in the treatment of pneumonia, bowel complaints, diarrhea, dysentery, eczema and ring worms. Tannins, flavonoids, saponins and alkaloids are the major components of P. plebeium. Since its use in folk medicine in Pakistan, there has been little scientific evidence or information on it. Therefore, this study was aimed at investigating the anti-fibrotic effects of P. plebeium in carbon tetrachloride (CCl4)-induced hepatic toxicity and fibrosis. Methods: The extracts of whole plant of P. plebeium were prepared and administered by oral gavage in rats. Liver fibrosis was induced by intraperitoneal (i.p.) administration of CCl4. To evaluate the hepatoprotective activity of P. plebeium, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (γGT) levels were quantified. Histological evaluation of liver tissue revealed tissue necrosis and extracellular matrix deposition. Real-time PCR was done to evaluate mRNA expression of genes related to liver fibrosis. Results: The groups treated with P. plebeium extract showed an ablation in liver damage; the elevated enzyme levels of ALT, AST and γGT were decreased. Treatment with P. plebeium extract treatment restored the CCl4-induced tissue fibrosis by significantly suppressing alpha-smooth muscle actin (α-SMA), tumor growth factor beta (TGF-β) and collagen mRNA expression levels. Histology of liver sections also showed that the CCl4-induced fibrosis was improved in the treatment groups. Conclusion: Polygonum plebeium has therapeutic potential and can be used for preventing fibrosis in inflammatory liver disease.

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Hepatoprotective potential and chemical characterization of Artocarpus lakoocha fruit extract

Cited by 14 publications

References 10 publications

Evaluation of Liver Protective Activity of Moringa oleifera Bark Extract in Paracetamol Induced Hepatotoxicity in Rats

Evaluation of Liver Protective Activity of Moringa oleifera Bark Extract in Paracetamol Induced Hepatotoxicity in Rats

Evaluation of liver protective activity ofMoringa oleiferabark extract in paracetamol induced hepatotoxicity in rats

Anti-fibrotic effects of polygonum plebeium r.br. in CCl4-induced hepatic damage and fibrosis in rats

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