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Background: Moringa oleifera has been used in folk medicine to alleviate several diseases. In the present study, ethanolic extract of Moringa oleifera bark has been investigated to study its potential on paracetamol induced hepatotoxicity on model rats. Methods: Rats (150–200 gm) were divided into 5 groups containing 6 animals each. Acute hepatotoxicity was induced by paracetamol (600 mg/kg body weight) administered once daily for one week whereas the extract of investigated plant was given orally throughout the whole experiment at 250 and 500 mg/kg body weight. Silymarin (100 mg/kg body weight) was given orally as standard hepatoprotective drug. The level of hepatic injury recovery was determined by the estimation of liver enzymes like SGPT, SGOT, ALP, Bilirubin, Total protein, globulin and Albumin. Results: Treatment with MO extract as well as standard hepatoprotective agent silymarin ameliorated plasma levels of hepatic enzymes. Body weight was improved significantly by MO extracts (p < 0.01), whereas liver weight was recovered insignificantly. SGPT, SGOT and ALP levels were improved very highly significantly (p<0.001) and highly significantly (p<0.01) at MO 250mg dose. While at the dose of 500 mg/kg ameliorated SGPT Level very highly significantly (p<0.001), SGOT Level highly significantly (p<0.01) but insignificant to ALP level.   Conclusion: The biochemical parameters provide evidence that the ethanolic extract of of Moringa oleifera bark has shown hepatoprotective activity.

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The present study evaluated the analgesic, anti-inflammatory and antioxidant activities of Alternanthera pungens kunth.The ethanolic extract of Alternanthera pungens (EAP) showed analgesic effects by exerting ameliorated reaction time 40.79% and 44.74% at a dose of 250 and 500 mg/kg,respectively, whereas standard was 41.78%  by the hot plate test. Results of writhing inhibition were statistically significant (p <0.05) when compared to control. In addition to that, anti-inflammatory effects were also evaluated against denaturation of protein and the result was significant. Scavenging activity of EAP was 80.95% at the concentration of 800µg/mL. Moreover, HPLC-DAD analysis of EAP was also carried out to determine the presence of phenolic constituents & noted the presence of  epicatechin,vanillin, p-coumaric acid etc. These studies inferred that EAP possesses analgesic, anti- inflammatory and antioxidant potential which might be due to presence of phytochemicals like flavonoids, tannins and phenolic compounds. Journal of Bangladesh Academy of Sciences, Vol. 42, No. 2, 129-136, 2018

Background: Type 2 diabetes mellitus (T2DM) is a chronic disease that is associated with insulin secretion, insulin action or both. Its development is directly connected with not only carbohydrate metabolism but also primarily on lipid metabolism. Oral hypoglycemic agents have been found with some serious complications which are major clinical problems. Treatment of DM with medicinal plants and plant based traditional medicine is a potential adjunct therapy to maintain better glycemic control with a fewer side effects. The present study investigated the antidiabetic effect of Bridelia stipularis L. leaves on alloxan induced type-2 diabetic rats. Methods: Diabetes was induced by a single dose of intraperitoneal injection of alloxan (150mg/kg) in SD rats of either sex and was divided into 5 groups of 6 animals each. Ethanolic extract of leaves from Bridelia stipularis (BS 250 and 500mg/kg) and glibenclamide (10mg/kg) were orally administered once daily for 21 days in the treatment and standard group respectively. Blood glucose