Investigation of Anti-diabetic Properties of Ethanol Leaf Extract of Bridelia stipularis L. on Alloxan Induced Type-2 Diabetic Rats

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a chronic disease that is associated with insulin secretion, insulin action or both. Its development is directly connected with not only carbohydrate metabolism but also primarily on lipid metabolism. Oral hypoglycemic agents have been found with some serious complications which are major clinical problems. Treatment of DM with medicinal plants and plant based traditional medicine is a potential adjunct therapy to maintain better glycemic control with a fewer side effects. The present study investigated the antidiabetic effect of Bridelia stipularis L. leaves on alloxan induced type-2 diabetic rats. Methods: Diabetes was induced by a single dose of intraperitoneal injection of alloxan (150mg/kg) in SD rats of either sex and was divided into 5 groups of 6 animals each. Ethanolic extract of leaves from Bridelia stipularis (BS 250 and 500mg/kg) and glibenclamide (10mg/kg) were orally administered once daily for 21 days in the treatment and standard group respectively. Blood glucose

Evaluation of Liver Protective Activity of Moringa oleifera Bark Extract in Paracetamol Induced Hepatotoxicity in Rats

“…Bangladesh, a country of great biodiversity of medicinal plants having a long history of use of traditional medicine along with phytotherapeutic potential mainly from native source. As a result, research in medicinal plants have been a huge area of discovering of promising lead compounds in Bangladesh [8,9]. Moringa oleifera, a medicinal plant of Bangladesh, belongs to the family moringaceae, is a small or middle sized tree, usually grows 10 -12 m in height.…”

Flavonoids from the Leaves of <i>Bridelia stipularis</i> with <i>in Vitro</i> Antioxidant and Cytotoxicity Activity

“…A wide range of biological activities have been also reported by Bridelia stipularis e.g. antibacterial and antifungal activity [7], anti-candidal [8], antioxidant [9], anti-diabetic [10], cytotoxicity [7] and thrombolytic [11].…”