Hepatoprotective potential of standardized Ficus species in intrahepatic cholestasis rat model: Involvement of nuclear factor-κB, and Farnesoid X receptor signaling pathways

El‐Hawary, Seham S.; Ali, Z; Younis, Inas Y.

doi:10.1016/j.jep.2018.11.026

Cited by 32 publications

(29 citation statements)

References 56 publications

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“…The NF-κB pathway has emerged as one of the best-characterized signaling pathways in the pathogenesis in many diseases, including liver diseases, inflammatory disorders and tumor development 34 . Many reports have demonstrated that NF-κB is considered to play a major role in HSCs activation leading to fibrogenesis 35,10 which agrrement with current histological and E.M findings. In the present study, anti-TB intoxicated drugs induce NF-kB expression indicating that anti-TB intoxicated drugs can induce the expression of inflammatory genes.…”

Section: Discussionsupporting

confidence: 60%

“…ALP is a membrane-bound glycoprotein enzyme, with high concentrations in sinusoids and endothelium and is excreted into the bile and its elevation in serum occurs in hepatobiliary diseases. 30,10 In the present study, pre-treatment with WGO caused a decrease in the activity of ALP when compared with anti-TB intoxicated drugs group, showing its anti-hepatotoxic potential. TP and ALB levels are indicators of liver function since the majority of plasma proteins and ALB are synthesized in the liver.…”

Section: Discussionsupporting

confidence: 52%

“…31 Lipid per oxidation is an autocatalytic process, which is a common consequence of cell death. The level of MDA indicates an enhanced lipid per oxidation leading to liver tissue injury and failure of antioxidant defense 10 . In the present study, a significant decrease in the MDA level was observed in the WGO treatment group when compared to the anti-TB intoxicated drugs model.…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress in the hepatocytes results in apoptosis is one of the attributing mechanisms of liver dysfunction caused by INH and RIF. 9,10 Also, the transforming growth factor -β (TGF-β) and matrix metalloproteinase (MMP2) activate the hepatic stellate cell (HSCs) to produced fibers due to elevating the amount of glycoprotein which transforms stellate cells to fibrogenic cells causing liver fibrosis. 11 Wheat germ oil (WGO) is an excellent source of natural vitamin E (Vit.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Possible Ameliorative Role of Wheat Germ Oil on Hepatotoxicity Induced by the Combination of Two Anti-Tubercular Drugs (Isoniazid and Rifampicin) in Rats

Moghazy¹,

Osman²,

Mahfouz³

2019

Int Res J Pharm

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The study was designed to evaluate the protective effect of wheat germ oil (WGO) against hepatotoxicity induced during treatment with the combination of two anti-tubercular (anti-TB) drugs, Isoniazid (INH) and Rifampicin (RIF) in rats. Fatty acid and Vit E. contents of WGO were assayed by GC-MS and HPLC respectively. Rats received WGO at two different doses (250 and 500 mg/kg. body weight, p. o, for 30 days) 30 minutes before Anti-TB drugs. Liver functions test, inflammatory mediator marker (IL-10 and NF-κB), oxidative stress (GSH, MDA) and NO were determined with different techniques. Furthermore, histological findings, immunohistochemical and ultra-structure were carried out. In-vitro analysis of the WGO revealed that linoleic and oleic acids were the major compounds, and WGO was rich in vitamin E. Significant elevation in liver enzymes, NF-κB, and depletion in IL-10, along with a disturbance in the antioxidant defense systems. Meanwhile, WGO improves all these changes in a dose-dependent manner as compared with the anti-TB intoxicated group. The hepatoprotective effect of WGO was confirmed with immune histochemical and histopathological findings. WGO has a hepatoprotective effect against hepatotoxicity induced by combined therapy of anti-TB drugs (INH+RIF).

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Section: Discussionsupporting

confidence: 60%

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Possible Ameliorative Role of Wheat Germ Oil on Hepatotoxicity Induced by the Combination of Two Anti-Tubercular Drugs (Isoniazid and Rifampicin) in Rats

Moghazy¹,

Osman²,

Mahfouz³

2019

Int Res J Pharm

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“…However, in the clinic, drug therapies and efficacy are limited for EIC patients. Currently, the first line treatment of cholestastic liver disease is ursodeoxycholic (UDCA) to which approximately 40% of patients have inadequate response (Woolbright and Jaeschke, 2016;El-Hawary et al, 2019). Therefore, it is of utmost importance to identify novel therapeutic compounds for the treatment of EIC.…”

Section: Introductionmentioning

confidence: 99%

Baicalin Protects Against 17α-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1α/Farnesoid X Receptor Pathway

Yang

Xiang

et al. 2020

Front. Pharmacol.

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Estrogen-induced cholestasis (EIC) is characterized by impairment of bile flow and accumulated bile acids (BAs) in the liver, always along with the liver damage. Baicalin is a major flavonoid component of Scutellaria baicalensis, and has been used in the treatment of liver diseases for many years. However, the role of baicalin in EIC remains to be elucidated. In this study, we demonstrated that baicalin showed obvious hepatoprotective effects in EIC rats by reducing serum biomarkers and increasing the bile flow rate, as well as by alleviating liver histology and restoring the abnormal composition of hepatic BAs. In addition, baicalin protected against estrogen-induced liver injury by up-regulation of the expression of hepatic efflux transporters and down-regulation of hepatic uptake transporters. Furthermore, baicalin increased the expression of hepatic BA synthase (CYP27A1) and metabolic enzymes (Bal, Baat, Sult2a1) in EIC rats. We showed that baicalin significantly inhibited hepatic inflammatory responses in EIC rats through reducing elevated levels of TNF-a, IL-1b, IL-6, and NF-kB. Finally, we confirmed that baicalin maintains hepatic BA homeostasis and alleviates inflammation through sirtuin 1 (Sirt1)/hepatic nuclear receptor-1a (HNF-1a)/ farnesoid X receptor (FXR) signaling pathway. Thus, baicalin protects against estrogeninduced cholestatic liver injury, and the underlying mechanism involved is related to activation of the Sirt1/HNF-1a/FXR signaling pathway.

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HPLC–ESI/MS profiling, phytoconstituent isolation and evaluation of renal function, oxidative stress and inflammation in gentamicin‐induced nephrotoxicity in rats of Ficus spragueana Mildbr. & Burret

Taher

Raslan

Masoud

et al. 2021

Biomedical Chromatography

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Ficus spragueana Mildbr. & Burret (family Moraceae) was reported to have various biological activities. However, its activity in treatment of renal injury has not been investigated yet. The current study aimed to evaluate the effects of F. spragueana leaf extract on nephrotoxicity caused by gentamicin. Gentamicin is an important broad‐spectrum antibiotic; nevertheless, it exhibits serious nephrotoxic adverse effects. HPLC–ESI/MS spectrometric analysis of the extract revealed the presence of 37 phenolic compounds. Moreover, five compounds were isolated from the leaf extract, and identified on the basis of spectroscopic analysis. The isolated compounds were syringic acid (1), p‐coumaric acid (2), 3′,5′ O‐dicaffeoylquinic acid (3), luteolin‐8‐C‐β‐D glucopyranoside (orientin) (4) and 8‐methoxy kaempferol‐3‐O‐[α‐L‐rhamnopyranosyl (1→2) β‐D‐glucopyranoside] (5). The gentamicin‐induced nephrotoxicity model was used to evaluate the protective effect of F. spragueana on renal toxicity biomarkers throughout the development of acute kidney injury. Administration of extract led to improvement in kidney function through inhibition of kidney injury molecule‐1, creatinine, blood urea nitrogen and total bilirubin, as well as decreasing the inflammatory markers interlukin1‐beta and myeloperoxidase. Furthermore, it reduced the oxidative stress by increasing reduced glutathione and total antioxidant capacity levels while decreasing malondialdehyde and nitric oxide content, and improved renal histopathological injuries.

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Hepatoprotective potential of standardized Ficus species in intrahepatic cholestasis rat model: Involvement of nuclear factor-κB, and Farnesoid X receptor signaling pathways

Cited by 32 publications

References 56 publications

Evaluation of Possible Ameliorative Role of Wheat Germ Oil on Hepatotoxicity Induced by the Combination of Two Anti-Tubercular Drugs (Isoniazid and Rifampicin) in Rats

Evaluation of Possible Ameliorative Role of Wheat Germ Oil on Hepatotoxicity Induced by the Combination of Two Anti-Tubercular Drugs (Isoniazid and Rifampicin) in Rats

Baicalin Protects Against 17α-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1α/Farnesoid X Receptor Pathway

HPLC–ESI/MS profiling, phytoconstituent isolation and evaluation of renal function, oxidative stress and inflammation in gentamicin‐induced nephrotoxicity in rats of Ficus spragueana Mildbr. & Burret

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