Hepatoprotective properties of Morinda pubescens J.E. Smith (Morinda tinctoria Roxb.) fruit extract

Abstract

The present study evaluated the hepatoprotective properties of Morinda pubescens fruit extract against D-galactosamine (D-GalN)-induced liver injury in rats. The fruit extract of M. pubescens was administrated orally at 200 mg/kg of body weight daily once for 21 days and at 21st day, D-GalN (500 mg/kg of body weight) was injected intraperitoneally in rats, to induce liver damage. In D-GalN administrated rats, significant increase in the levels of serum marker enzymes and lipid peroxidation (LPO) in liver and decreased serum and liver antioxidant levels were observed. Pre-treatment with fruit extract to rats reduced the elevated levels of serum marker enzymes and also improves the levels of fucose, ceruloplasmin, and uric acid. Administration of M. pubescens fruit extract prevented increase of LPO and alteration in iron content in experimental animals, besides, considerably increased the levels of glutathione (GSH) and vitamin E when compared to D-GalN intoxicated animals. The present results suggest that the M. pubescens fruit extract has liver-protective property against D-GalN-induced liver injury in rats, which was further confirmed by histopathological studies. The hepatoprotective potentials of fruits of M. pubescens may be due to the presence of phenols and alkaloids, as analyzed by preliminary phytochemical analysis of fruit extract.

Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress

“…In this study, we found that pretreatments with AEMA (50-200 mg/kg) could markedly downregulate the elevated serum levels of ALT and AST in mice exposed to CCl 4 , which means that AEMA possesses the potential protective effect against the hepatotoxicity induced by CCl 4 in mice. is result is consistent with the findings that Morinda citrifolia juice and ethanol extract of Morinda pubescens fruit reduced the increased AST and ALT activities [23,24]. In addition, the isolated anthraquinone, soranjidiol, exhibited suppression effects on elevated ALT and AST activities similar to those of AEMA, which suggested that soranjidiol should be one of the main hepatoprotective constituents of M. angustifolia.…”

Anticancer Activity of Methanolic Leaf Extract of Morinda Tinctoria Roxb. Against Ehrlich Ascites Carcinoma in Mice

“…The ripe fruits of Morinda tinctoria are used for respiratory disorders, arthritis, cancer, gastric ulcer and heart diseases, relieve pain, purify the blood and stimulate the immune system, an effective antioxidant, acts as an antibiotic resistant (Wang et al 2002). Literature survey revealed that this plant exhibited potent antimicrobial (Janakiraman et al 2012), anti-inflammatory (Sivaraman and Muralidharan, 2010), antidiabetic (Pattabiraman and Muthukumaran, 2011), hepatoprotective (Surendiran and Mathivanan, 2011), antiradical (Desai et al 2010), antihyperglycemic and antidiabetic (Palayan and Dhanasekaran, 2009), In vitro free radical scavenging (Sreena et al 2011) and cytoprotective activity (Sivaraman and Muralidharan, 2011). Therapeutically active iridoid glycoside was also isolated from Morinda tinctoria (Roxb.)…”

Evaluation of Bioactivities of Morinda Tinctoria Leaves Extract for Pharmacological Applications.

“…The hepatoprotective nature of M. tinctoria was demonstrated in D-galactosamine-induced liver damaged rats. The level of serum markers (alanine aminotransferase and aspartate aminotransferase) was reduced, and the antioxidant level was increased significantly on M. tinctoria intervention to the liver damaged rats [27]. In the present study, in vitro anti-inflammatory property of M. tinctoria extract was estimated by evaluating the protease inhibition and prevention of protein denaturation properties.…”