Hepatoprotector activity of iridoid glycosides with respect to heliotrine-induced acute toxic liver damage in mice

Сыров, В. Н.; Nabiev, A.; Хушбактова, З. А.; Zakhidov, U. V.; Maksudov, M. S.; Saatov, Z.

doi:10.1007/bf02510088

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…In our laboratory, chemical investigation of the whole plant has shown it to be a major source of two naturally occurring bioactive iridoid glucosides, namely, plantarenaloside (1) and boschnaloside (2). Iridoids exhibit a wide range of bioactivities including hepatoprotective, cardiovascular, antihepatotoxic, chlorectic, hypoglycemic, anti-inflammatory, antispasmodic, antitumor, antiviral, immunomodulator, and purgative activities [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Comparative Estimation of Major Iridoid Glucosides from Different Parts of Incarvillea emodi

Rana

Singh

Dhyani

2012

ISRN Chromatography

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Incarvillea emodi (Bignoniaceae) is a rich source of bioactive iridoid glucosides. This plant contains two major iridoid glucosides: plantarenaloside, a neurotropic compound, and boschnaloside, a strong antibacterial compound. Here, in this study we have developed a simple and fast HPLC-DAD method for the total comparative estimation of these two major iridoids from different parts of Incarvillea emodi. A linear calibration curve (r 2 = 0.999) for both iridoid glucosides in varying range (15.6-500 µg/ml) is obtained. The limit of detection (LOD) and limit of quantification (LOQ) for plantarenaloside were 11.4 ng and 38 ng and for boschnaloside were 22.8 ng and 76 ng, respectively. The shoots, roots, and flowers of Incarvillea emodi have a combined presence of 7.66, 1.22, and 6.99 percent of these iridoid glucosides on dry weight basis. In shoots, plantarenaloside shows complete dominance (6.78%) over boschnaloside (0.88%), and a reversal of this trend was observed in case of flowers where boschnaloside shows complete dominance (6.12%) over plantarenaloside (0.87%). The roots contain 1.19% and 0.03% of both iridoids, respectively.

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Section: Introductionmentioning

confidence: 99%

Comparative Estimation of Major Iridoid Glucosides from Different Parts of Incarvillea emodi

Rana

Singh

Dhyani

2012

ISRN Chromatography

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Lamiide and Ipolamiide: A Comprehensive Review of Their Bioactive Properties and Therapeutic Potential

Sobhy,

AbouZid,

Kirollos

et al. 2024

Chemistry & Biodiversity

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There is an increasing interest in using iridoids and secoiridoids as major targets for chemical synthesis and biosynthesis. Iridoids can be found in numerous species of Lamiaceae, Verbenaceae, Scrophulariaceae, and other families. Iridoids possess a chemical structure characterized by a cyclopentane ring with oxidative substituents, forming a six‐membered ring. Various research groups have used these structures as valuable starting materials for regioselective and stereoselective synthesis. This approach has enormous potential for the production of bioactive alkaloids, prostaglandin analogues, and other bioactive natural compounds. Because there is currently no review on lamiide and ipolamiide, this review intends to pique researchers' interest in this vital topic of natural science for drug discovery from naturally occurring iridoids. Lamiide and ipolamiide have the potential to be useful tools in the pharmaceutical sector, enabling the use of these plant metabolites in a variety of medicinal compositions. Given that these molecules appear to be potential natural substances for treating human ailments, we get light on them as alternative therapeutic approaches using these compounds alone or in combination with other substances which will potentially lead to future (pre)‐clinical investigations.

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Harpagide: Occurrence in plants and biological activities - A review

et al. 2020

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Hepatoprotector activity of iridoid glycosides with respect to heliotrine-induced acute toxic liver damage in mice

Cited by 4 publications

References 2 publications

Comparative Estimation of Major Iridoid Glucosides from Different Parts of Incarvillea emodi

Comparative Estimation of Major Iridoid Glucosides from Different Parts of Incarvillea emodi

Lamiide and Ipolamiide: A Comprehensive Review of Their Bioactive Properties and Therapeutic Potential

Harpagide: Occurrence in plants and biological activities - A review

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