Hepatoprotectors of vegetable origin in therapy of drug-induced hepatitis

Минушкин, О. Н.; Зверков, И. В.; Островская, А. И.

doi:10.21518/2079-701x-2016-14-48-51

Cited by 2 publications

(1 citation statement)

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“…In the treatment of DILLs, hepaprotectors are used for pathogenetic therapy; the choice of them depends on the leading disease mechanism (Minushkin et al 2016). The effect of hepatoprotectors is aimed at restoring liver homeostasis, increasing the organ's resistance to pathogenic factors, normalization of its functional activity and stimulation of reparative regeneration processes in the liver (Kovtun et al 2011;Kucheryavy and Morozov 2012;Vyalov 2013).…”

Section: Introductionmentioning

confidence: 99%

Treatment of hepatitis induced by anti-tuberculosis drugs (experimental research)

Федоров¹,

Смирнов²,

Вдовиченко³

et al. 2020

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Introduction: Tuberculosis is a widely spread infection. While treating patients for it, they are given simultaneously and for a long period 5-6 antibacterial drugs, which are, as a rule, bad for the liver. It quite often (up to 20%) causes drug-induced hepatitis. As experimental means of protecting the liver, the following peptides are suggested: chorionic gonadotropin, a recombinant drug of luteinizing hormone – luveris, and oligopeptide drugs: semax and selank. Materials and Methods: The research was conducted on 104 outbred white male rats weighing 170-220 g. Each group included at least 10 animals. Drug-induced hepatitis was simulated through the combined 21-day administration of isoniazid, rifamycin, and ethanol. Chorionic gonadotropin, luveris, semax and selank, as well as a comparison drug mexidol, were administered once a day during the experiment. Healthy control animals and rats with drug-induced hepatitis were used as comparison groups. For evaluation of the efficiency of administered drugs, the obtained biochemical and histomorphological research data was used. Results and Discussion: During the experiment, chorionic gonadotropin (ChG), semax and selank showed a greater therapeutic activity than mexidol and luveris. Only in the case of administering ChG, selank and semax, there was parallelism between the restoration of biochemical parameters of blood and histomorphological parameters of the liver. Administering both selank and ChG was also characterized by more active regenerative processes. Conclusion: Administering ChG, selank and semax to patients with tuberculosis would significantly reduce the number and severity of hepatotoxic reactions.

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Section: Introductionmentioning

confidence: 99%

Treatment of hepatitis induced by anti-tuberculosis drugs (experimental research)

Федоров¹,

Смирнов²,

Вдовиченко³

et al. 2020

RRP

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Selank and semax as potential hepatoprotectors in medical treatment of tuberculosis

Petrovsky¹,

Смирнов²,

Вдовиченко³

et al. 2019

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Introduction: Drug-induced hepatitis is common in clinical practice. This problem is particularly relevant in the treatment of tuberculous infection, because for this purpose, up to 5–6 hepatotoxic drugs are used simultaneously for a long time, which often (in 15–20% of cases) leads to medical liver lesion. To protect the liver, Semax and Selank are offered – drugs of regulatory peptides group. Materials and Methods: The research was conducted on 96 outbred white male rats weighing 180–220 g. The experimental group included about 10 animals. Drug-induced hepatitis was simulated through the combined 21-day administration of isoniazid, rifampicin and ethanol. Semax and Selank, as well as Essentiale N and Mexidol (comparison drugs) were administered once a day during the experiment. Healthy control animals with experimental hepatitis were used for comparison. Subsequently, the obtained biochemical and histomorphological parameters were evaluated. Results and Discussion: In the experiment, Semax and Selank showed a greater therapeutic activity than the recognized hepatoprotectors – Essentiale and Mexidol. Only in the case of administering Selank and Semax, there was parallelism between the restoration of biochemical parameters of blood and histomorphological parameters of the liver. Selank was also characterized by an increased activity of regenerative processes. Conclusion: Administering Selank and Semax to patients with tuberculosis would significantly reduce the number and severity of hepatotoxic reactions.

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Hepatoprotectors of vegetable origin in therapy of drug-induced hepatitis

Cited by 2 publications

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Treatment of hepatitis induced by anti-tuberculosis drugs (experimental research)

Treatment of hepatitis induced by anti-tuberculosis drugs (experimental research)

Selank and semax as potential hepatoprotectors in medical treatment of tuberculosis

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