Introduction: Drug-induced hepatitis is common in clinical practice. This problem is particularly relevant in the treatment of tuberculous infection, because for this purpose, up to 5–6 hepatotoxic drugs are used simultaneously for a long time, which often (in 15–20% of cases) leads to medical liver lesion. To protect the liver, Semax and Selank are offered – drugs of regulatory peptides group. Materials and Methods: The research was conducted on 96 outbred white male rats weighing 180–220 g. The experimental group included about 10 animals. Drug-induced hepatitis was simulated through the combined 21-day administration of isoniazid, rifampicin and ethanol. Semax and Selank, as well as Essentiale N and Mexidol (comparison drugs) were administered once a day during the experiment. Healthy control animals with experimental hepatitis were used for comparison. Subsequently, the obtained biochemical and histomorphological parameters were evaluated. Results and Discussion: In the experiment, Semax and Selank showed a greater therapeutic activity than the recognized hepatoprotectors – Essentiale and Mexidol. Only in the case of administering Selank and Semax, there was parallelism between the restoration of biochemical parameters of blood and histomorphological parameters of the liver. Selank was also characterized by an increased activity of regenerative processes. Conclusion: Administering Selank and Semax to patients with tuberculosis would significantly reduce the number and severity of hepatotoxic reactions.

This article discusses the evaluation of pharmacological effectiveness of drugs of different pharmacotherapeutic groups in an experimental model of toxic hepatitis. The method of two-stage pharmacological screening. Key findings: of immunomodulators were found drugs worsen the condition of the liver against toxic hepatitis, the combination of essential phospholipids and glycyrrhizic acid is substantially more important hepatoprotective activity, in comparison with the effectiveness of this combination of components that are applied separately, the number of members of the group of adaptogens immunostimulant effect of which is the only one component of their actions, have a more pronounced hepatoprotective activity compared with the specialized immunomodulators.

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The aim of the study was to assess efficacy and safety of 24-month treatment with Seretide (salmeterol / fluticasone propionate, 100 / 1 000 mcg daily) or Flixotide (fluticasone propionate, 1 000 mcg daily) in 105 steroid-dependent asthma patients aged 18 to 60 yrs who had received oral steroids for at least 6 months but not longer than 10 years. Methods. The study was comparative, randomized, multicentre, open in parallel groups (15 visits with 2-week intervals). Reduction of oral steroid doses started at the 3-rd visit. Results. In spite of the continual treatment with oral steroids patients did not reach asthma control. After 6-month therapy with fluticasone propionate or salmeterol / fluticasone propionate the maintaining dose of prednisolone was 6 times lower in comparison with baseline. Moreover, oral steroids were abolished in each second patient receiving Seretide and each third patient receiving Flixotide. The asthma control and quality of life significantly increased. Conclusion. The therapy with fluticasone propionate or salmeterol / fluticasone propionate allows to reduce doses of oral steroids and to cease oral steroids in most causes. Moreover, the patients can maintain good asthma control.

The article’s author suggests, that philosophy in Indian culture didn’t arised as a ritual’s overcoming, but arised as a ritual thinking’s development, the most important of that is the unity of word, thought and action, founded on the participants’ ritual’s and everything’s, that happens in it, symbolic identification’s with absolute, eternal divine life’ developments (first of all — world’s creation). The acts of philosophical thought, described in the "older" Upanishads, — this isn’t abstract thinking about world’s principles, which replaced the vedic sacrifice, and a new, more perfect form of sacrificial ritual’s performing, and a special, sacred Knowledge, which has not an epistemological, but a soteriological meaning. The purpose of such philosophy is not to know the world but is an achieving immortality through the sacralization of all things. For this purpose, the most important is the ontologization of the priest-brahman’s figure, transformed into the image of Brahman as the absolute life’s found and the inner essence of the ″self″ (this transformation is described in brahman texts — symbolic comments on the vedic ritual), and the meaning of the ritual formula ya evam veda ("who knows so"), the form of development of which is the philosophical formulas of the Upanishads. Just as the Brahman priest creates the sacral space of the ritual identifying himself and everything, that happens inside the ritual, with the Prajapati’s sacrifice, who creates the world, so Upanishad thinkers sacralize everything that exists and themselves through the understanding the identity of atman and brahman. This understanding is an act of ritual identity, not a theoretical interpretation. The author of the article was helped by the concept of "ritual symbolism" by V.S. Sementsov, who understands Vedic sacrifice as a special type of thinking.