Hepatotherapeutic Effect of Aloe Vera in Alcohol-induced Hepatic Damage

Saka, W.A.; Akhigbe, R.E.; Ishola, O S; Ashamu, Ebenezer Adeola; Olayemi, OS; Adeleke, G. E.

doi:10.3923/pjbs.2011.742.746

Cited by 33 publications

(20 citation statements)

References 12 publications

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“…High level of AST and ALT in Aloe unsupplemented fish, especially after challenge, may be an indication of high loss of functional integrity of the hepatic cell and cellular leakage of this enzyme into the bloodstream due to S. iniae impact. The findings agree with those by Saka et al (2011) who reported that A. vera significantly counteracted high serum AST and ALT activity in alcohol-induced rats. In the same line, Zodape (2010) showed that administration of A. vera juice significantly decreased glutamate-oxaloacetate transaminase (GOT), glutamate-pyruvate transaminase (GPT), acid, and alkaline phosphatase (ACP and ALP) enzymes in liver and muscle tissues of chromium-induced Labeo rohita, which is an indication of effective hepatoprotective and tissue-protective property of A. vera against toxic.…”

Section: Discussionsupporting

confidence: 95%

“…Reportedly, Aloe extracts improved growth performance in GIFTtilapia (Gabriel et al 2015), common carp (Mahdavi et al (2013), and rainbow trout (Heidarieh et al 2013). Moreover, Aloe extracts revealed protective effects against lipid peroxidation in common carp and rainbow trout (Farahi et al 2012), as well as hepatotherapeutic effects in rats (Saka et al 2011;Moon et al 2008). The present study intended to investigate the effect of dietary A. vera on lipid profile status, antioxidant, and hepatoprotective enzyme activities of GIFT-tilapia juveniles under S. iniae challenge.…”

Section: Introductionmentioning

confidence: 93%

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Dietary Aloe vera improves plasma lipid profile, antioxidant, and hepatoprotective enzyme activities in GIFT-tilapia (Oreochromis niloticus) after Streptococcus iniae challenge

Gabriel

Qiang

et al. 2015

Fish Physiol Biochem

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The current study investigated the effects of dietary Aloe vera on plasma lipid profile status, antioxidant, and hepatoprotective enzyme activities of GIFT-tilapia juveniles under Streptococcus iniae challenge. Five dietary groups were designed including a control and 100 % Aloe powder incorporated into a tilapia feed at 0.5, 1, 2, and 4 %/kg feed, which were administered for 8 weeks. Fish fed dietary Aloe at 4 %/kg feed significantly reduced in total cholesterol, while triacylglycerol reduced (P < 0.05) in those fed 0.5, 2, and 4 % Aloe/kg feed compared to unsupplemented ones. High-density lipoprotein was significantly elevated in fish fed 0.5 and 1 % Aloe/kg feed compared to unsupplemented ones, and no significant changes (P > 0.05) were noted in low-density lipoprotein among test groups. Furthermore, high activities of superoxide dismutase, catalase, and glutathione peroxide in liver tissues were observed in Aloe-supplemented fish compared to unsupplemented ones, before and after S. iniae challenge (7.7 × 10(6) CFU cells/mL). Variations were also noted in malondialdehyde activity throughout the trial, but no significant difference (P > 0.05) was observed between groups. Meanwhile, Aloe-supplemented fish reduced serum aspartate and alanine aminotransferase (AST and ALT) activities before and after challenge. Based on the second-order polynomial regression analysis, dietary Aloe inclusion levels less than or equal to 1.88, 1.86, and 2.79 %/kg feed were determined to be suitable in improving plasma lipid profile status, antioxidant, and hepatoprotective enzyme activities in GIFT-tilapia in this study, respectively. Thus, A. vera extracts may be recommended as a tilapia feed supplement to enhance fish antioxidant and hepatoprotective capacities, especially during disease outbreaks.

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Section: Discussionsupporting

confidence: 95%

Section: Introductionmentioning

confidence: 93%

Dietary Aloe vera improves plasma lipid profile, antioxidant, and hepatoprotective enzyme activities in GIFT-tilapia (Oreochromis niloticus) after Streptococcus iniae challenge

Gabriel

Qiang

et al. 2015

Fish Physiol Biochem

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“…A previous study has described that Aloe vera gel had a hepatotherapeutic effect on alcohol-induced liver damage. 26) However, the protective effect of AVGE on alcoholic fatty liver was uncertain. We have demonstrated in this study that an AVGE pre-treatment significantly suppressed the accumulation of hepatic lipids induced by ethanol administration (Fig.…”

Section: Discussionmentioning

confidence: 99%

Aloe veraGel Extract Attenuates Ethanol-Induced Hepatic Lipid Accumulation by Suppressing the Expression of Lipogenic Genes in Mice

Stenmark-Askmalm

Tanaka

Misawa

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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“…Therefore to reinforce the positive results obtained from various studies done for hepatoprotective activity of aloe Vera, like Hepatoprotective potential of Aloe Barbedensis against CCL4 induced hepatotoxicity 5 .Hepatoprotective activity of Aloe vera gel against Paracetamol induced hepatotoxicity in Albino rats 15 , Hepatotherapeutic effect of Aloe vera in alcohol induced hepatic damage 18 .The present the study was conducted for evaluation of the hepatoprotective activity of Aloe vera in patients with acute liver diseases.…”

Section: Introductionmentioning

confidence: 71%

Untitled

2014

IJPSR

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Background & objectives: Liver diseases are one of the major causes of disease burden all over world including our country so it is the need of hour to search for alternative drugs for the treatment of liver diseases. Aloe Vera is one of the most popular plants in the world, and is has been used frequently in history for its medicinal properties. Material &Methods: A total of 110 male and female patients of age group between 15-65 years, diagnosed clinically and biochemically as the case of acute viral hepatitis and ready to give consent were recruited in the study from SVBP Hospital, LLRM Medical College Meerut (U.P), 250004. Subjects who fulfilled selection criteria were randomized into two groups. Fifty patients belonging to control group received conventional treatment for acute viral hepatitis while 60 patients enrolled in treated group were given conventional treatment for acute viral hepatitis supplemented with Aloe vera juice (Patanjali Ayurved ltd, Haridwar) in dose of 20 ml BD orally. Every patient was followed up for 6 weeks. Serum bilirubin, serum Alanine transaminase (ALT), serum Aspartate transaminase (AST) and serum Alkaline phosphatase (ALP) levels were measured initially and at the end of 2, 4 and 6 weeks. Results, Interpretation & Conclusions: Intragroup comparison using repeated measure ANOVA demonstrated a statistically significant (p<0.001) decrease in above mentioned parameters for both treated and control groups at all intervals of time. Intergroup comparison done by student-t-test, revealed statistically significant (p<0.001) difference in all the mentioned parameters between treated and control groups at all intervals of times.

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Hepatotherapeutic Effect of Aloe Vera in Alcohol-induced Hepatic Damage

Cited by 33 publications

References 12 publications

Dietary Aloe vera improves plasma lipid profile, antioxidant, and hepatoprotective enzyme activities in GIFT-tilapia (Oreochromis niloticus) after Streptococcus iniae challenge

Dietary Aloe vera improves plasma lipid profile, antioxidant, and hepatoprotective enzyme activities in GIFT-tilapia (Oreochromis niloticus) after Streptococcus iniae challenge

Aloe veraGel Extract Attenuates Ethanol-Induced Hepatic Lipid Accumulation by Suppressing the Expression of Lipogenic Genes in Mice

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