Hepatotoxicity and nephrotoxicity in rats induced by carbon tetrachloride and the protective effects of<i>Teucrium polium</i>and vitamin C

Rahmouni, Fatma; Badraoui, Riadh; Amri, Nahed; Elleuch, Aïda; Elfeki, Abdelfattah; Rebaï, Tarek; Saoudi, Mongi

doi:10.1080/15376516.2018.1519864

Cited by 26 publications

(21 citation statements)

References 32 publications

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“…In fact, several bioactive compounds have been reported in the organic extracts of the tested plant species [ 91 ]. Previous reports showed that T. polium possessed potential therapeutic properties in some health problems including toxicity and cytogenic diseases [ 92 ]. In this study, further efficient activities could be outlined particularly the ability to treat bacterial infectious diseases and to inhibit cell-to-cell communication (quorum sensing).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Alreshidi

Noumi

Bouslama

et al. 2020

Plants

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The chemical profile of Teucrium polium L. (T. polium) methanolic extract was tested using liquid chromatography coupled with high resolution mass spectrometry (HR-LCMS). Disc diffusion and microdilution assays were used for the antimicrobial activities. Coxsackievirus B-3 (CVB3) and Herpes simplex virus type 2 (HSV-2) were used for the antiviral activities. Chromobacterium violaceum (ATCC 12472 and CV026) and Pseudomonas aeruginosa PAO1 were used as starter strains for the anti-quorum sensing tests. Isoprenoids are the main class of compounds identified, and 13R-hydroxy-9E,11Z-octadecadienoic acid, valtratum, rhoifolin, sericetin diacetate, and dihydrosamidin were the dominant phytoconstituents. The highest mean diameter of growth inhibition zone was recorded for Acinetobacter baumannii (19.33 ± 1.15 mm). The minimal inhibitory concentrations were ranging from 6.25 to 25 mg/mL for bacterial strains, and from 6.25 to 25 mg/mL for Candida species. The 50% cytotoxic concentration on VERO (African Green Monkey Kidney) cell lines was estimated at 209 µg/mL. No antiviral activity was recorded. Additionally, T. polium extract was able to inhibit P. aeruginosa PAO1 motility in a concentration-dependent manner. However, the tested extract was able to inhibit 23.66% of the swarming and 35.25% of swimming capacities of PAO1 at 100 µg/mL. These results highlighted the role of germander as a potent antimicrobial agent that can interfere with the virulence factors controlled by the quorum-sensing systems.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Alreshidi

Noumi

Bouslama

et al. 2020

Plants

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“…66 There is still a lack of scientific evidence to authenticate the hepatoprotective properties of some natural products, which are used traditionally to treat liver disorders. 67 Its therapeutic and some biological effects have been evaluated antioxidant, antigastric, and hepatoprotective. 68 The study performed by Rahmouni et al, 69 the hepatoprotective activity of aqueus extract of T. polium was investigated using carbon tetrachloride (CCl 4 )-induced liver damage in rats.…”

Section: Hepatoprotective Effects Of T Poliummentioning

confidence: 99%

Therapeutics studies and biological properties of Teucrium polium (Lamiaceae)

2021

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Teucrium polium has been used in traditional medicine as antifungal, antipyretic, antispasmodic, and antibacterial. It is consumed by many jordanians for the treatment of many diseases. The effects of this plant have been investigated in kidney, liver, and brain. Its antidiabetic, antimicrobial, antioxidant, and anticancer effects have been introduced. Polyphenolic compound, flavonoids, monoterpenes, alkanoides, and essential oils were identified. Several studies revealed that this plant has a hypoglycemic effect and can help to control blood sugar. It was reported that plants containing flavonoids and phenolics compounds exhibit a large array of biological activities like genotoxicity (chromosomal aberrations and sister chromatid exchange) and oxidative stress damage. These phytochemicals are found in herbal and vegetables plants, as well as being reliably protective against oxidative stress damage and lipid peroxidation. In addition, T. polium has secondary effects on different organs, namely liver, kidney and at high doses this plant becomes toxic. In conclusion, this review investigates many pharmacologicals properties and side effects of T. polium.

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“…Thus, antioxidant enzyme also plays an important role in the detoxification of xenobiotics, catalyzing their conjugation with reduced GSH. Free radicals in CCl 4 intoxication are a major pathway of non-enzymatically induced lipid peroxidation, which subsequently affect various enzyme activities in the body and therefore, may also be linked to enzymatically induced lipid peroxidation [55]. As a result, we suggest that crude extracts protects against significantly decreased catalase activities in rats treated with CCl 4 compared with control rats.…”

Section: Discussionmentioning

confidence: 75%

In vivo and in vitro hepatoprotective effect of three endemic plants against carbon tetrachloride-induced liver damage in rats

Boubellouta

Touhami

Mahdi

2021

Acta Scientifica Naturalis

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The aim of the study was to investigate in vitro potential antioxidant and hepatoprotective effects of methanolic extracts from the aerial parts of Matricaria pubescens, Centaurea incana, and Santolina africana, against carbon tetrachloride induced liver damage in rats. The different aerial parts of three methanolic extracts, exhibited antioxidant activity in the DPPH free radical (IC50, 0.032, 0.087 and 0.044 mg/ml) respectively. The reducing ability of the extracts showed a dose-dependent trend increasing with increase in the concentrations of the extracts.The antioxidant activity of samples at the concentration of 2 mg/ml was reflected in their ability to inhibit the bleaching of β-carotene. Treated groups with extracts of studied three plants showed decrease in plasma levels of AST, ALT, ALP, and an increase in plasma catalase levels activities, while hepatic MDA decreased and catalase increased as compared to carbon tetrachloride treated groups. In consistency with in vivo and in vitro results, extracts of all three plants ameliorated the carbon tetrachloride extensive damage to liver tissue of treated animals, but, Santolina africana extract was the most efficient.

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Hepatotoxicity and nephrotoxicity in rats induced by carbon tetrachloride and the protective effects ofTeucrium poliumand vitamin C

Cited by 26 publications

References 32 publications

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Therapeutics studies and biological properties of Teucrium polium (Lamiaceae)

In vivo and in vitro hepatoprotective effect of three endemic plants against carbon tetrachloride-induced liver damage in rats

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