Hepatotoxicity of stanozolol in cats

Abstract

Results suggest that stanozolol is hepatotoxic in cats.

Coagulation in hepatobiliary disease

“…Perioperative bleeding tendencies, however, were not commonly reported in dogs undergoing biliary surgery in these studies . The finding that prolongations in PT or aPTT carry prognostic significance suggests the coagulation changes may represent hepatic synthetic failure or the presence of DIC rather than vitamin K deficiency …”

“…Studies evaluating coagulation testing and bleeding tendencies in cats with hepatobiliary disease, the majority of which have cholestatic disorders (eg, cholangitis, hepatic lipidosis), have shown that alterations in coagulation profile are common (45–73% of cases) . Most of these studies have concluded on the basis of the presence of PIVKA (protein invoked by vitamin K absence), FVII analysis, or by response to therapy that the majority of these cats had a vitamin K dependent coagulopathy rather than hepatic synthetic failure . It is important to note that 22% of the cats in one of these studies with abnormal coagulation tests did have increased bleeding tendencies, all of which were associated with provocative procedures, such as venipuncture or intravenous catheter placement .…”

Acute liver failure in dogs and cats

“…Stanozolol is an anabolic steroid that has been associated with both an acute ALI as well as delayed fatal ALF during a 4 week clinical trial of 21 cats. Cats with gingivitis and stomatitis were more likely to develop delayed ALF …”

Evaluation of Prophylactic and Therapeutic Effects of Silymarin on Diazepam-Induced Hepatotoxicity in Cats

“…Acute hepatic injury may be caused by a direct toxic effect of the drug or its metabolites on the hepatocyte, producing a predictable dose-dependent effect, or by idiosyncratic drug reactions, which occur unpredictably in a small number of cats exposed to a particular drug such as diazepam (Lappin, 2001). Harkin et al (2000) suggested that stanozolol was hepatotoxic in cats.…”