Hepcidin – central regulator of iron metabolism

Atanasiu, Valeriu; Manolescu, Bogdan Nicolae; Stoian, Irina

doi:10.1111/j.1600-0609.2006.00772.x

Cited by 104 publications

(91 citation statements)

References 92 publications

(106 reference statements)

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“…Thus, selenium could potentially play a role in the anemia of chronic inflammation through its relationship with the upregulation of interleukin-6. In addition, interleukin-6 has been implicated in the upregulation of hepcidin, the iron regulatory hormone which has a function in the anemia of chronic inflammation is through a central role in regulation of iron metabolism also providing a link between iron metabolism and inflammation and innate immunity (30,31). It has also been shown that selenium deficiency causes anemia among animals and has been associated with a hemolytic anemia (32).…”

Section: Discussionmentioning

confidence: 99%

Relationship of Low Serum Selenium to Anemia among Primary School Children Living in Rural Vietnam

Nhien

Khan²,

Yabutani

et al. 2008

J Nutr Sci Vitaminol

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Summary A cross-sectional study of 292 primary school children was conducted in rural Vietnam to investigate the relationship among micronutrient deficiencies, and other risk factors for anemia. Serum levels of iron, copper, zinc, selenium and magnesium were determined by inductively coupled plasma mass spectrometry and that of retinol by high performance liquid chromatography. Hemoglobin concentration in whole blood was measured by the cyanmethemoglobin method. The incidence of low serum zinc, selenium, magnesium, and copper in the children was 91.4, 75.6, 59.5, and 8.6%, respectively. Forty-five percent of the children were anemic and 11.3% suffered from vitamin A deficiency. A parameter significant associated with anemia was low serum selenium and vice versa (OR 1.85, 95% CI 1.06-3.24, p Ͻ 0.05). Other factors associated with anemia were serum retinol Ͻ 1.05 mol/L (OR 2.05, 95% CI 1.25-3.36, p Ͻ 0.01), and age in years (OR 1.59, 95% CI 1.16-2.18, p Ͻ 0.01). The study showed that low selenium is associated with anemia among school children in Vietnam. Interventions are required to gain insight into the potential role of selenium on prevention and control of anemia.

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Section: Discussionmentioning

confidence: 99%

Relationship of Low Serum Selenium to Anemia among Primary School Children Living in Rural Vietnam

Nhien

Khan²,

Yabutani

et al. 2008

J Nutr Sci Vitaminol

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“…) pela hefestina (Heph), uma oxidase semelhante à ceruloplasmina sérica, responsável por essa conversão (ATANASIU et al, 2006).…”

Section: +unclassified

Mutações genéticas, métodos diagnósticos e terapêuticas relacionadas à hemocromatose hereditária

et al. 2013

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ResumoA hemocromatose hereditária é uma doença genética relacionada a diversos distúrbios do metabolismo do ferro e uma das causas mais importantes da sobrecarga de ferro. Os avanços técnicos e cientíicos obtidos nas últimas décadas, principalmente com o desenvolvimento da biologia molecular, têm contribuído para o maior conhecimento do metabolismo do ferro e dos principais fatores relacionados à sua regulação, bem como dos distúrbios que podem resultar em déicit ou sobrecarga. A identiicação de alguns genes e suas mutações auxiliou no entendimento dos mecanismos regulatórios responsáveis pela manutenção da homeostase desse nutriente essencial para numerosos processos bioquímicos. Assim, esta revisão aborda aspectos relacionados ao ferro, seu metabolismo e as causas da sobrecarga, particularmente a desenvolvida pela hemocromatose hereditária. Ainda em relação a essa doença, apresenta-se diagnóstico, orientações sobre o tratamento e mutações mais frequentes.Palavras-chave: Diagnóstico molecular; Gene HFE; C282Y; H63D; Sobrecarga de ferro Abstract Genetic mutations, diagnostic methods, and therapies related to hereditary haemochromatosis.Hereditary haemochromatosis is a genetic disease related to various iron metabolism disorders and a major cause of iron overload. The technical and scientiic advances obtained over the last decades, particularly with the development of molecular biology, have contributed to greater knowledge on iron metabolism and the main factors related to its regulation, as well as the disorders that can result in deicit or overload. The identiication of some genes and their mutations has helped to understand the regulatory mechanisms responsible for maintaining the homeostasis of such an essential mineral for several biochemical processes. Thus, this review addresses aspects related to iron, its metabolism and the causes for overload, particularly that deriving from hereditary haemochromatosis. Also with regard to this disease, we present diagnosis, guidance on treatment, and most frequent mutations.

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“…Inside the cell, absorbed Fe 2 binds to ferritin heading to the basolateral membrane, where ferroportin is located, present in enterocytes, macrophages, and hepatocytes, which is a protein required for Fe 2 transport into plasma 20,[34][35][36] .…”

Section: Hepcidin Expression Related To Iron Deficiency Anemiamentioning

confidence: 99%

A hepcidina como parâmetro bioquímico na avaliação da anemia por deficiência de ferro

Lemos¹,

Ismael²,

Boato³

et al. 2010

Rev. Assoc. Med. Bras.

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Hepcidin – central regulator of iron metabolism

Cited by 104 publications

References 92 publications

Relationship of Low Serum Selenium to Anemia among Primary School Children Living in Rural Vietnam

Relationship of Low Serum Selenium to Anemia among Primary School Children Living in Rural Vietnam

Mutações genéticas, métodos diagnósticos e terapêuticas relacionadas à hemocromatose hereditária

A hepcidina como parâmetro bioquímico na avaliação da anemia por deficiência de ferro

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