Heptapeptide-loaded solid lipid nanoparticles for cosmetic anti-aging applications

Suter, Franz; Schmid, Daniel; Wandrey, Franziska; Zülli, Fred

doi:10.1016/j.ejpb.2016.06.014

Cited by 60 publications

(19 citation statements)

References 9 publications

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“…We expected a lower entrapment efficiency for SLNs, since they are known to possess low loading capacity for hydrophilic compounds [36]. However, Suter and collaborators [37] have recently demonstrated that SLNs might also incorporate high load of hydrophilic compounds, such as peptides, which is in agreement with our results. CLs containing rhodamine incorporated the highest amount of the marker compared to both DLs and SLNs ( Table 1).…”

Section: Characteristics Of the Phospholipid-based Nanosystemssupporting

confidence: 90%

Going skin deep: A direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model

Ternullo

Weerd

Holsæter

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

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Phospholipid-based nanocarriers are attractive drug carriers for improved local skin therapy. In the present study, the recently developed isolated perfused human skin flap (IPHSF) model was used to directly compare the skin penetration enhancing potential of the three commonly used nanocarriers, namely conventional liposomes (CLs), deformable liposomes (DLs) and solid lipid nanoparticles (SLNs). Two fluorescent markers, calcein (hydrophilic) or rhodamine (lipophilic), were incorporated individually in the three nanosystems. The nanocarrier size ranged between 200 and 300nm; the surface charge and entrapment efficiency for both markers were dependent on the lipid composition and the employed surfactant. Both carrier-associated markers could not penetrate the full thickness human skin, confirming their suitability for dermal drug delivery. CLs exhibited higher retention of both markers on the skin surface compared to DLs and SLNs, indicating a depo formation. DLs and SLNs enabled the deeper penetration of the two markers into the skin layers. In vitro and ex vivo skin penetration studies performed on the cellophane membrane and full thickness pig/human skin, respectively, confirmed the findings. In conclusion, efficient dermal drug delivery can be achieved by optimization of a lipid nanocarrier on the suitable skin-mimicking model to assure system's accumulation in the targeted skin layer.

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Section: Characteristics Of the Phospholipid-based Nanosystemssupporting

confidence: 90%

Going skin deep: A direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model

Ternullo

Weerd

Holsæter

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

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show abstract

“…Two approaches are used to produce SLNs and NLCs using HPH, which are hot and cold homogenization. For hot HPH, drugs and molten lipids are mixed at temperatures typically 5–10 °C higher than the solid lipid melting point; drugs are either dissolved or homogeneously dispersed in the molten lipids [ 50 ]. Generally, the concentration of lipids in resultant SLNs and NLCs dispersion is 5–10% (w/v).…”

Section: Methods For Slns and Nlcs Preparationmentioning

confidence: 99%

Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

2020

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Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as potential drug delivery systems for various applications that are produced from physiological, biodegradable, and biocompatible lipids. The methods used to produce SLNs and NLCs have been well investigated and reviewed, but solvent injection method provides an alternative means of preparing these drug carriers. The advantages of solvent injection method include a fast production process, easiness of handling, and applicability in many laboratories without requirement of complicated instruments. The effects of formulations and process parameters of this method on the characteristics of the produced SLNs and NLCs have been investigated in several studies. This review describes the methods currently used to prepare SLNs and NLCs with focus on solvent injection method. We summarize recent development in SLNs and NLCs production using this technique. In addition, the effects of solvent injection process parameters on SLNs and NLCs characteristics are discussed.

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“…In an ex vivo study with skin explants, Suter et al confirmed that SLN loading a hydrophilic peptide with antioxidant capacity could stimulate NADPH quinone oxidoreductase, heme oxygenase-1, and peroxiredoxin-1 genes as an approach to protect cells from UV induced stress, as these are cell protecting enzymes [58]. The skin treated with the developed SLN formulation showed a significant reduction of the DNA damage in comparison to the placebo formulation.…”

Section: Solid Lipid Nanoparticles (Sln) and The Nanostructured Lipidmentioning

confidence: 99%

Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals

et al. 2020

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Skin aging is described as dermatologic changes either naturally occurring over the course of years or as the result of the exposure to environmental factors (e.g., chemical products, pollution, infrared and ultraviolet radiations). The production of collagen and elastin, the main structural proteins responsible for skin strength and elasticity, is reduced during aging, while their role in skin rejuvenation can trigger a wrinkle reversing effect. Elasticity loss, wrinkles, dry skin, and thinning are some of the signs that can be associated with skin aging. To overcome skin aging, many strategies using natural and synthetic ingredients are being developed aiming to reduce the signs of aging and/or to treat age-related skin problems (e.g., spots, hyper- or hypopigmentation). Among the different approaches in tissue regeneration, the use of nanomaterials loaded with cosmeceuticals (e.g., phytochemicals, vitamins, hyaluronic acid, and growth factors) has become an interesting alternative. Based on their bioactivities and using different nanoformulations as efficient delivery systems, several cosmeceutical and pharmaceutical products are now available on the market aiming to mitigate the signs of aged skin. This manuscript discusses the state of the art of nanomaterials commonly used for topical administration of active ingredients formulated in nanopharmaceuticals and nanocosmeceuticals for skin anti-aging.

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Heptapeptide-loaded solid lipid nanoparticles for cosmetic anti-aging applications

Cited by 60 publications

References 9 publications

Going skin deep: A direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model

Going skin deep: A direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model

Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals

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