HER-2/neu Overxpression in Esophageal Squamous Cell Carcinoma (ESCC) and Its Correlation with Patient’s Clinicopathological Features

Kermani, Ali Taghizadeh; Vakili, Rosita; Dadkhah, Samaneh; Jafarian, Amir Hossein; Bagheri, Reza

doi:10.17795/ijcp-5007

Cited by 3 publications

(6 citation statements)

References 27 publications

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“…Researchers have observed a significant correlation between CD10 expression and increasing grade 25 and lymph node involvement. 4 5 17 23 24 Complimenting this finding, a higher intensity of CD10 expression has been noted more often in grade III tumors, N2/N3 tumors compared to grade II tumors, and N0 / N1 tumors. Studies have reported that factors like necrosis, desmoplasia, and LVI are associated with aggressive nature, poor prognosis, and early recurrence/death.…”

Section: Discussionmentioning

confidence: 81%

“…Though majority of breast tumors are hormone dependent or express HER2 and have appropriate treatment targeting these pathways, triple-negative tumors form a significant number. Studies have reported a statistically significant correlation between CD10 expression and ER/PR negativity 2 3 4 5 7 and HER2/neu positivity, 2 3 but data correlating CD10 expression with molecular subtypes is limited. In the present study, CD10 expression was seen more often in triple negative and HER2 molecular subtypes of tumors compared to luminal A and luminal B subtypes and CD10 expression was of higher intensity in triple negative and HER2 types are the aggressive molecular variants, while in luminal A and Luminal B subtypes, expression was of lower intensity.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies suggest that extracellular proteinase regulates growth factors and cytokines contributing to cancer invasion and metastasis. 4 The matrix molecules play an important role in malignancies and knowledge of such stromal markers will help identification of potential therapeutic targets. 2,5,6 The continuous and bilateral molecular crosstalk between normal epithelial cells and stromal cells is affected by several factors like growth factors, chemokines, extracellular matrix (ECM) molecules as well as ECM-modifying enzymes, including matrix metalloproteinases (MMPs) secreted by tumor cells or stromal cells and they represent the most prominent group of proteinases associated with tumor progression.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stromal Expression of CD10 in Breast Carcinoma and Its Association with Known Prognostic Factors—A Tissue Microarray-Based Study

Gaffoor

Krishnamurthy

2023

J Lab Physicians

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Background Breast cancer is an epithelial malignancy; however, stroma plays a key role with its stimulatory and inhibitory factors in modulating tumor invasion and metastasis. CD10, a matrix metalloproteinase, is known to regulate cell adhesion, migration and helps in determining the progression of tumor. This knowledge helps to identify specific signals that promote growth, dedifferentiation, invasion, metastasis and serve as target for better therapeutic management. Objectives The aim of this study was to estimate frequency of expression of stromal CD10 and assess its prognostic significance in breast carcinomas by correlating with known prognostic factors. Materials and Methods Morphological parameters of 62 cases of carcinoma breast were studied on H&E (hematoxylin and eosin) stained sections and expressions of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2/neu), and CD10 on manually constructed tissue microarray sections by immunohistochemistry (IHC). Staining pattern, percentage of stained cells, and intensity of stains were evaluated and IHC scoring of all markers was done. CD10 scores were correlated with the known prognostic factors (ER, PR, and HER2/neu). A p-value less than 0.05 was considered as significant. Results Stromal expression of CD10 was found in 82.3% of cases and it was significantly associated with increasing tumor size (p = 0.012), increasing tumor grade (p = 0.001), lymph node metastasis (p = 0.018), necrosis (p = 0.008), lymphovascular invasion (p = 0.008), ER negativity (p = 0.001), PR negativity(p = 0.007), HER 2 positivity (p = 0.012), triple-negative molecular subtypes (p = 0.001), and poor prognostic groups (p = 0.01). Conclusion CD10 can be used as an independent prognostic stromal marker and this will help to envisage new therapeutic strategies.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stromal Expression of CD10 in Breast Carcinoma and Its Association with Known Prognostic Factors—A Tissue Microarray-Based Study

Gaffoor

Krishnamurthy

2023

J Lab Physicians

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“…Meantime, they showed that HER2 expression was associated with moderately differentiated carcinoma cells without any significance. Raziee et al [16] studied 100 cases of gastric carcinoma in Iran and found a significant association of HER -2/Neu ( 26%) over expression with grade differentiation in Lauren's tumor. Further, in contrast with above mentioned, they had stated that their study did not reveal any association of HER2 expression with age, gender, location of tumor and depth of infiltration in patients.…”

Section: Discussionmentioning

confidence: 99%

Analytical Study of Diagnostic Role of Her2/Neu Expression In Gastroesophageal Lesions

Sheikh

Kumar

Rao

et al. 2021

JPRI

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Esophageal squamous cell carcinoma is one of the common types of malignant lesion and has its highest prevalence round the world. Though it is a common disorder, many of the patients only diagnose it in its advanced stage and these results in poor prognosis of the disease. In later stage, these lesions may severely develop in to lymph node metastasis and has more chances to spread across any of the vital organs. Barrett‟s esophagus, herpes simplex esophagitis, candidial esophagitis, leiomyoma, hyperplastic polyps are few of the benign and premalignant type of lesions. The advancement in endoscopy has opened many opportunities and diagnosis of all esophageal lesions became simple and effective. As the surgical procedures associated with the targeted therapy have become promising option for the treatment, many patients are being benefited out of technological advancement. The surplus of malignancies such as esophagus, esophago- gastric junction and stomach have become a significant health problem and threatening the people all over the world. Delayed diagnosis on these disorders particularly resulting in high mortality ratio and warrant for a systematic evaluation in patients. In this context, the present study analyse the association and prognostic significance of HER2/ neu in gastroesophageal lesions with other factors like age, size, histological type and grading and the incidence and distribution of gastroesophageal lesions in patients.

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An Observational Study of Stromal CD10 Expression in Breast Carcinoma and Its Association with Clinicopathological Parameters at SMS Medical College and Hospital

Sharma,

Hemrajani,

Harsh

et al. 2024

Asian Pac J Cancer Biol

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Introduction: Female breast cancer is now more prevalent than lung cancer worldwide, with an estimated 2.3 million new cases worldwide, or 11.7% of all cancer cases. Breast cancer is an epithelial malignancy, but tumor microenvironment i.e. stroma plays remarkable role in invasion and metastasis. The cross talk between tumor cells and stromal cells is critical step in tumor progression as a result there is increased interest in developing novel therapies targeting the microenvironment. Aim and Objectives: To study the frequency and intensity of stromal CD10 expression in invasive breast cancer and to correlate it with various clinicopathological parameters.Materials and Methods: The study was conducted in Department of Pathology at S.M.S. Medical College, Jaipur. CD 10 expression in 70 patients diagnosed with carcinoma breast during the period of 2021-2022, assessed by immunohistochemistry and scored as negative (<10% stromal positivity), weak (10-30% stromal positivity) and strong (>30% stromal positivity) and statistically analyzed with other parameters. Results and Discussion: Out of the 70 cases, 51 (72.86%) showed CD10 positivity in the stroma, with 28 (40%) showing strongly positive and 23 (32.86%) with weakly positive results. With respect to histopathological grade (P value = 0.0234), molecular subtype (P value = 0.0006), and PR negativity (P value = 0.0480), CD10 expression in the stroma showed a positive correlation. Conclusion: The correlation between stromal expression of CD10 and histopathological grade, molecular subtype, and PR negativity was statistically significant. To confirm CD10 expression in invasive breast cancer as a predictor of overall survival rates and disease-free survival, more research is required..

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HER-2/neu Overxpression in Esophageal Squamous Cell Carcinoma (ESCC) and Its Correlation with Patient’s Clinicopathological Features

Cited by 3 publications

References 27 publications

Stromal Expression of CD10 in Breast Carcinoma and Its Association with Known Prognostic Factors—A Tissue Microarray-Based Study

Stromal Expression of CD10 in Breast Carcinoma and Its Association with Known Prognostic Factors—A Tissue Microarray-Based Study

Analytical Study of Diagnostic Role of Her2/Neu Expression In Gastroesophageal Lesions

An Observational Study of Stromal CD10 Expression in Breast Carcinoma and Its Association with Clinicopathological Parameters at SMS Medical College and Hospital

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