Herb-induced aconitine poisoning

Tomlinson, Brian; Chan, ThomasY.K; Chan, JulianaC.N; Critchley, JulianA.J.H.

doi:10.1016/0140-6736(93)90169-h

Cited by 18 publications

(5 citation statements)

References 3 publications

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“…The amount and composition of Aconitum alkaloids are the main factors determining the severity of intoxication and vary greatly with different species, time of harvesting, and the method of processing 2. Although the curing process reduces the toxicity of the aconites, patients may not follow the instructions precisely and the variable amounts of active ingredients within the root make the effect of this process unpredictable 3. The main causes of death are cardiovascular collapse caused by ventricular tachyarrhythmia 4…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone

Yeih

Ft²,

Huang³

2000

Heart

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With the increasing trend of cross mixing of populations, aconitine induced poisoning and its related arrhythmias may be more frequently encountered worldwide. However, the clinical experience is often too limited to draw any conclusion on the optimal treatment for tachycardia induced by aconitine intoxication. The clinical presentation, serial electrocardiographic changes, and responses to antiarrhythmic agents are reported in a patient with aconitine induced life threatening ventricular tachyarrhythmia. Amiodarone was eVective in suppressing polymorphic ventricular tachycardia, which might provide an example of successful pharmacological intervention in aconitine induced ventricular tachyarrhythmia. (Heart 2000;84:e8)

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Section: Discussionmentioning

confidence: 99%

Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone

Yeih

Ft²,

Huang³

2000

Heart

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“…However, poisonings and even fatalities have occurred in Asia and some western countries due to its inappropriate use. [1][2][3][4][5][6][7] Aconitine (ACO), the main component of this herb, is primarily responsible for its fatal effects, which is also referred to as the queen of poisons. 8 However, apart from the inherent toxicity of the drug, other factors plausibly contribute to the occurrence of poisoning due to plants belonging to the genus Aconitum, including improper dose selection, inappropriate processing method, consumption of the raw drug, and lack of awareness regarding the toxicity of the drug among patients.…”

Section: Introductionmentioning

confidence: 99%

Spatial distribution and comparative analysis of Aconitum alkaloids in Fuzi using DESI-MSI and UHPLC-QTOF-MS

Ren

Zhang

Liu

et al. 2023

Analyst

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“…Aconitine exerts pharmacological effects, such as dispelling wind and dampness, and easing menstrual cramps and pain (1). In China, it is considered common practice to soak Radix aconitiagrestis and Radix aconiti sinensisin wine or to add Kusnezoff monkshood root slices when cooking food.…”

Section: Introductionmentioning

confidence: 99%

“…Aconitine is the main toxic component of Aconitum plants. It exerts effects mainly on the heart and nervous system, causing a variety of arrhythmias and leading to death (1). Its therapeutic dose is close to the poisonous or lethal dose, and it is a typical representative of poisonous plants with medicinal value (2).…”

Section: Introductionmentioning

confidence: 99%

Clinical effect of a temporary pacemaker on an electrical storm induced by severe acute aconitine poisoning

Feng

Liu

2022

World Acad Sci J

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In China, medicinal liquor made from the aconitine root soaked in wine is poisoned. At present, reliable detoxification drugs are not available. The present study used a temporary pacemaker to treat 12 patients who required treatment due to an electrical storm caused by aconitine poisoning between June, 2017 and April, 2021. The results revealed that temporary pacing was successful in all 12 patients. The electrode placement rate was 100%, and the effective cardiac pacing rate was 100%. The blood pressure of the patients gradually returned to normal levels. Ventricular tachycardia and high-grade atrioventricular block were terminated. As regards atrial premature beats and ventricular premature beats, the sinus rhythm was restored after continuous amiodarone pumping. Simultaneously, fluid supplementation and control supportive treatment were administered. The patients were hospitalized for 4-6 days. The patients' symptoms disappeared, their vital signs were stable and their electrocardiogram (ECG) exhibited normal findings. The 12 patients were followed-up for 1 week following discharge and did not have any discomfort; the ECG revealed no abnormalities. On the whole, the findings of the present study suggest that temporary cardiac pacing may be an effective treatment for malignant arrhythmias caused by severe acute aconitine poisoning. However, the present study only involved a very small number of cases. In the future, further studies are required with larger sample, and further randomized, controlled multi-center studies are also warranted to these findings.

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Herb-induced aconitine poisoning

Cited by 18 publications

References 3 publications

Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone

Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone

Spatial distribution and comparative analysis of Aconitum alkaloids in Fuzi using DESI-MSI and UHPLC-QTOF-MS

Clinical effect of a temporary pacemaker on an electrical storm induced by severe acute aconitine poisoning

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