Herb pairs containing Angelicae Sinensis Radix (Danggui): A review of bio-active constituents and compatibility effects

Jin, Yi; Qu, Cheng; Tang, Yuping; Pang, Haijun; Liu, Liling; Zhu, Zhenhua; Shang, Erxin; Shi, Haiyang; Sun, Dazheng; Duan, Jin‐Ao

doi:10.1016/j.jep.2016.01.033

Cited by 74 publications

(50 citation statements)

References 53 publications

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“…Danggui and Honghua, combined as a classical herb pair, have been frequently used in TCM prescriptions5. Through data mining and pharmacological approaches, this herb pair was found to produce synergistic and complementary effects to treat BSS646566676869. However, the complexity of the chemical components of this herb pair and their corresponding multiple targets in vivo led to extreme difficulty to elucidate the molecular mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach

Yue

Xin

Fan

et al. 2017

Sci Rep

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118

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Herb pair Danggui-Honghua has been frequently used for treatment of blood stasis syndrome (BSS) in China, one of the most common clinical pathological syndromes in traditional Chinese medicine (TCM). However, its therapeutic mechanism has not been clearly elucidated. In the present study, a feasible system pharmacology model based on chemical, pharmacokinetic and pharmacological data was developed via network construction approach to clarify the mechanisms of this herb pair. Thirty-one active ingredients of Danggui-Honghua possessing favorable pharmacokinetic profiles and biological activities were selected, interacting with 42 BSS-related targets to provide potential synergistic therapeutic actions. Systematic analysis of the constructed networks revealed that these targets such as HMOX1, NOS2, NOS3, HIF1A and PTGS2 were mainly involved in TNF signaling pathway, HIF-1 signaling pathway, estrogen signaling pathway and neurotrophin signaling pathway. The contribution index of every active ingredient also indicated six compounds, including hydroxysafflor yellow A, safflor yellow A, safflor yellow B, Z-ligustilide, ferulic acid, and Z-butylidenephthalide, as the principal components of this herb pair. These results successfully explained the polypharmcological mechanisms underlying the efficiency of Danggui-Honghua for BSS treatment, and also probed into the potential novel therapeutic strategies for BSS in TCM.

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Section: Discussionmentioning

confidence: 99%

Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach

Yue

Xin

Fan

et al. 2017

Sci Rep

Self Cite

118

121

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“…; Jin et al . ). In China, TCMs are often combined as a formula (TCMF) being used in basic researches and production applications.…”

Section: Introductionmentioning

confidence: 97%

Effects of traditional Chinese medicine formula on ruminal fermentation, enzyme activities and nutrient digestibility of beef cattle

Zhu

Song

Cao

et al. 2018

Animal Science Journal

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This study was conducted to evaluate effects of traditional Chinese medicine formula (TCMF) combined with several herbs on ruminal fermentation, enzyme activities and nutrient digestibility. Twenty finishing bulls were assigned to control or different TCMFs (Yufeisan-1, -2, -3; 2.5% dry matter (DM) in concentrate). Results showed that DM intake was higher (P < 0.05) in the Yufeisan-3 group than others. Compared to control, apparent digestibility of crude protein and neutral detergent fiber were increased (P < 0.05) by Yufeisan-3. No changes were observed in ruminal pH, concentrations of ammonia-N, microbial crude protein and total volatile fatty acid, whereas ratio of acetate to propionate was lower (P < 0.05) and propionate proportion tended to be higher (P < 0.1) in three TCMFs than control. Ruminal xylanase (P = 0.061) and carboxymethylcellulase (P < 0.05) activities were higher in Yufeisan-3 than control. No changes were observed in abundance of total bacteria, fungi and protozoa, whereas Fibrobacter succinogenes (P = 0.062) and Ruminococcus flavefaciens (P < 0.05) were increased and total methanogens was reduced (P = 0.069) by Yufeisan-3 compared to control. Yufeisan-3 improved nutrient digestibility and ruminal enzyme activity, and modified fermentation and microbial community, maybe due to the presence of Herba agastaches, Cortex phellodendri and Gypsum fibrosum.

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“…Due to the complexity of chemical composition, only using a single index or a simple superposition method could not be feasible to unveil the multi-herb synergistic characteristics of TCM (Jin et al, 2016). Thus, recently, researchers tried to use knockout/knockin chromatography, bioactive equivalence oriented feedback screening method (Song et al, 2016) and system pharmacology strategy (Huang et al, 2014; Zhang W.J.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Evaluation of the Compatibility Effects of Huangqin Decoction on the Treatment of Irinotecan-Induced Gastrointestinal Toxicity Using Untargeted Metabolomics

et al. 2017

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Huangqin decoction (HQD), a traditional Chinese medicine (TCM), has been widely used to treat gastrointestinal syndrome in China for thousands of years. Chemotherapy drug irinotecan (CPT-11) is used clinically to treat various kinds of cancers but limited by its side effects, especially delayed diarrhea. Nowadays, HQD has been proved to be effective in attenuating the intestinal toxicity induced by CPT-11. HQD consists of four medicinal herbs including Scutellaria baicalensis Georgi, Glycyrrhiza uralensis Fisch, Paeonia lactiflora Pall, and Ziziphus jujuba Mill. Due to its complexity, the role of each herb and the multi-herb synergistic effects of the formula are poorly understood. In order to quantitatively assess the compatibility effects of HQD, mass spectrometry-based untargeted metabolomics studies were performed. The serum metabolic profiles of rats administered with HQD, single S. baicalensis decoction, S. baicalensis-free decoction and baicalin/baicalein combination were compared. A time-dependent trajectory upon principal component analysis was firstly used to visualize the overall differences. Then metabolites deregulation score and relative area under the curve were calculated and used as parameters to quantitatively evaluate the compatibility effects of HQD from the aspect of global metabolic profile and the specifically altered metabolites, respectively. The collective results indicated that S. baicalensis played a crucial role in the therapeutic effect of HQD on irinotecan-induced diarrhea. Both HQD and SS decoction regulated glycine, serine and threonine pathway. This study demonstrated that metabolomics was a promising tool to elucidate the compatibility effects of TCM or combinatorial drugs.

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Herb pairs containing Angelicae Sinensis Radix (Danggui): A review of bio-active constituents and compatibility effects

Cited by 74 publications

References 53 publications

Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach

Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach

Effects of traditional Chinese medicine formula on ruminal fermentation, enzyme activities and nutrient digestibility of beef cattle

Quantitative Evaluation of the Compatibility Effects of Huangqin Decoction on the Treatment of Irinotecan-Induced Gastrointestinal Toxicity Using Untargeted Metabolomics

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