Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women

Yan, Fangfang; Liu, Yan; Liu, Yunfang; Zhao, Yong

doi:10.1002/ptr.2451

Cited by 29 publications

(13 citation statements)

References 32 publications

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“…HE has been demonstrated to decrease the total cholesterol and triglyceride levels, however to increase estradiol (13), and flavonoid components of HE have been reported to have antioxidant properties (14). HE flavonoids stimulate osteoblast formation and suppress the process of osteoclastogenesis in ovariectomized mice, and thus prevent bone loss in this model (15).…”

Section: Introductionmentioning

confidence: 99%

Effects of herbal Epimedium on the improvement of bone metabolic disorder through the induction of osteogenic differentiation from bone marrow-derived mesenchymal stem cells

Kim

Lee

Shim

et al. 2016

Molecular Medicine Reports

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Herbal Epimedium (HE) has been commonly used as a tonic, antirheumatic agent and in the treatment of bone-associated diseases including osteoporosis. Treatment for osteoporosis is important to increase bone mass density and maintain to balance of bone remodeling. The present study was performed to investigate the effects of HE on mouse bone marrow mesenchymal stem cell (mBMMSC) proliferation and osteogenic differentiation, using MTT assays, proliferating cell nuclear antigen (PCNA) detection and apoptosis and differentiation assays. HE was demonstrated to inhibit the proliferation of mBMMSCs up to 45.43±3.33% and to decrease the level of PCNA expression compared with untreated cells. HE also induced late apoptosis at 24 and 48 h after treatment up to 71.93 and 67.03%, respectively, while only 14.93% of untreated cells exhibited apoptosis. By contrast, HE induced differentiation of mBMMSCs into an osteogenic lineage at the beginning of three weeks after commencement of treatment. This suggested that HE is a candidate as an inducer of osteogenesis from bone marrow mesenchymal stem cells, and additionally has potential for use in the treatment of bone metabolic disorders such as osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Effects of herbal Epimedium on the improvement of bone metabolic disorder through the induction of osteogenic differentiation from bone marrow-derived mesenchymal stem cells

Kim

Lee

Shim

et al. 2016

Molecular Medicine Reports

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“…However, no recurrence of menstruation was reported in any of the subjects. (32) Another clinical trial on 50 late postmenopausal women, who were randomised to take either herb-derived phyto-oestrogen flavonoids (60 mg icariin, 15 mg genistein and 3 mg daidzein) or a placebo daily for 24 months, reported no significant increase in the treatment group's serum oestradiol level. Interestingly, as with animal data, bone mineral density was maintained in the treatment group but was significantly reduced in the placebo group, without a concurrent hyperplasia effect on endometrium thickness.…”

Section: Herbs With Oestrogenic Activity Epimedium (Herba Epimedii Ymentioning

confidence: 99%

Steroids in traditional Chinese medicine: what is the evidence?

Fung

Linn

2017

smedj

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Local healthcare providers often question the possible steroidal activity of traditional Chinese medicine (TCM) herbs or herbal products and implicate them as a cause for adrenal insufficiency or Cushing's syndrome in patients with a history of TCM intake. We conducted a comprehensive database search for evidence of potential glucocorticoid, mineralocorticoid, androgenic or oestrogenic activity of herbs or herbal products. Overall, there are not many herbs whose steroidal activity is well established; among these, most cases were based on preclinical studies. Liquorice root may cause pseudoaldosteronism through interference with the steroidogenesis pathway. Although ginseng and cordyceps have some in vitro glucocorticoid activities, the corroborating clinical data is lacking. Deer musk and deer antler contain androgenic steroids, while epimedium has oestrogenic activity. On the other hand, adulteration of herbal products with exogenous glucocorticoids is a recurrent problem encountered locally in illegal products masquerading as TCM. Healthcare providers should stay vigilant and report any suspicion to the relevant authorities for further investigations.

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“…3 Phytoestrogens are assumed to produce minimal side effects and studies have shown that phytoestrogens are effective in the prevention and amelioration of the metabolism of sex hormones and blood lipids in women who are postmenopausal. 4 Asparagus racemosus (AR), also called shatavari, is a member of the familly Liliaceae, an Indian climbing plant. While in Thailand, AR is known as rak-sam-sib or sam-roi-rak.…”

Section: Introductionmentioning

confidence: 99%

Effects of Asparagus racemosus Root Extracts on Serum Lipid Profiles, Lipid Peroxidation and Superoxide Dismutase in Ovariectomized Rat

Taepongsorat¹,

Phadungkit²

2018

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Background: Once rats have been ovariectomized they have a high risk of cardiovascular disease due to changes in the blood cholesterol and lipid profile. Objective: To investigate the effects of Asparagus racemosus (AR) root extract on the serum lipid profiles, lipid peroxidation and antioxidant levels in ovariectomized rats. Methods: Twenty-five, two month-old female Wistar rats were randomly divided into five groups: SH, OVX,OEE, OAAR and OEAR. The daily doses of 500 mg/KgBW of the AR root extracts for five weeks.The levels of serum TG, TC, HDL, LDL, the liver, kidney and uterine tissue lipid peroxidation and SOD levels were determined. Results: Serum TC and LDL showed no significant differences in any groups. Serum TG of the OAAR and OEAR groups were not significantly different. The serum HDL of the OAAR and OEAR groups were significantly lower than the OEE group. The liver MDA levels of the OAAR and OEAR groups were significantly decreased compared with the OVX and OEE groups while the SOD level of the OAAR group was significantly increased. The MDA levels in the kidney and uterine of the treated group showed no significant difference. The SOD levels in the kidney of the treated group were not different but the SOD levels in uterine were significantly decreased. Conclusion: It can be believed that the lipid profiles were maybe regulated via estrogen.The AR extract has low effects on the lipid profiles at this dose and duration of treatment. The capacity of the extracts to decrease the MDA level and increase the SOD level in this study clearly reflected the antioxidant efficiency of these substances. or sam-roi-rak. The extracts of the roots of AR have in the last few years been determined to have a phytoestrogenic effect and help with neurodegenerative disorders, in addition to effects on antidiarrheal, antidyspepsia, adaptogenic, cardioprotective, antibacterial, immunoadjuvant and antitussive.5 There are two major forms in which the root extracts of AR have been used (methanolic and aqueous extracts) as tablets, powders in tablets or a syrup form. 6 In addition, there have been reports of activities related to immunostimulant, antihepatotoxic or antioxytocic. 5 In laboratory animals, there have been recent reports the extracts of AR roots have antioxidant and antidiarrheal effects. [7][8] In rats, the lipid peroxidation (malondialdehyde: MDA) decreased while there were increases in superoxide dismutase (SOD), catalase and ascorbic acid by the methanolic root extracts.

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Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women

Cited by 29 publications

References 32 publications

Effects of herbal Epimedium on the improvement of bone metabolic disorder through the induction of osteogenic differentiation from bone marrow-derived mesenchymal stem cells

Effects of herbal Epimedium on the improvement of bone metabolic disorder through the induction of osteogenic differentiation from bone marrow-derived mesenchymal stem cells

Steroids in traditional Chinese medicine: what is the evidence?

Effects of Asparagus racemosus Root Extracts on Serum Lipid Profiles, Lipid Peroxidation and Superoxide Dismutase in Ovariectomized Rat

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