Herbal drug incorporated antibacterial nanofibrous mat fabricated by electrospinning: An excellent matrix for wound dressings

Abstract

Nano-components and nano-systems for health care and medical applications are the focus of many research projects worldwide. Nanofibrous membranes are highly soft materials with high surface-to-volume ratios, and therefore can serve as excellent carriers for therapeutic agents that are antibacterial or accelerate wound healing. PCL/PVP Nanofiber mat containing chloroform: methanol (4:1) crude bark extract of Tecomella undulata, a medicinal plant widely known for its traditional medical applications including its wound healing ability, were prepared and evaluated for their antibacterial properties. With good drug stability and high drug-loading efficacy, the incorporation of herbal extract in the polymer media did not appear to influence the morphology of the resulting fibers, as both the drug-free and the drugloaded nanofibers remained unaltered, microscopically. Activity was tested against standard strains of Pseudomonas aeruginosa MTCC 2297, Staphylococcus aureus ATCC 933, Escherichia coli (IP-406006). Extract loaded PCL/PVP nanofiber mat were able to inhibit the growth of the bacterial strains which indicate that it could act not only as a drug delivery system but also in the treatment of wound healing or dermal bacterial infections thereby proving a potential application for use as a wound dressing.

Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane

“…The ester COO vibrations occur at 1163 and 1240 cm -1 . The O-C vibrations occur at the peak of 1107, 1047 and 961 cm -1 , with the CH 2 vibration appearing at 732 cm -1 (Suganya et al 2011). The infrared spectrum of PCL nanofibers containing nHA showed almost the same results at all characteristic peaks.…”

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

“…To supplement and enhance the general wound dressing functions several different strategies have been developed, namely those involving the incorporation of bioactive compounds (e.g. growth factors, peptides, synthetic drugs and/or naturally based compounds/extracts) and of stem cells into dressing matrices in order to prepare medicated dressings [89][90][91][92].…”

Incorporation and Release Kinetics of Alpha-Bisabolol From PCL and Chitosan/Guar Gum Membranes

“…The intense peak at 1722 cm -1 refers to stretching of the carbonyl groups (-C=O), while peaks at 1187 and 1243 cm -1 are related to vibrations of ester groups. The peak at 1295 cm -1 corresponds to stretching of C-O and C-C bonds and the peak at1369 cm -1 is related to vibrations of -CH2 groups (Khatiwala et al, 2008;Suganya et al, 2011;Martínez-Abad et al, 2013).…”