Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice

Fan, Xiaoqing; Mai, Chu-Tian; Zuo, Lei; Huang, Jumin; Xie, Chun; Jiang, Ze‐Bo; Li, Runze; Yao, Xiaojun; Fan, Xing‐Xing; Wu, Qibiao; Yan, Pingkun; Liu, Liang; Chen, Jianxin; Xie, Ying; Leung, Elaine Lai-Han

doi:10.1016/j.apsb.2022.10.016

Cited by 28 publications

(10 citation statements)

References 57 publications

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“…Changes in intestinal immunity are inextricably linked to the intestinal microbiota, and we found that FMD significantly increased the abundance of Lactobacillus johnsonii . As reported in the existing literature, this probiotic was able to alleviate colitis by enhancing the anti-inflammatory activity of macrophages 43 and also improve memory capacity in mice through the brain–gut axis. 44 Further exploration of its association with intestinal aging will help to elucidate the mechanism underlying the anti-aging effects of FMD.…”

Section: Discussionsupporting

confidence: 65%

Fasting mimicking diet extends lifespan and improves intestinal and cognitive health

Wang,

Xu,

Luo

et al. 2024

Food Funct.

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Section: Discussionsupporting

confidence: 65%

Fasting mimicking diet extends lifespan and improves intestinal and cognitive health

Wang,

Xu,

Luo

et al. 2024

Food Funct.

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“…Therefore, Serine/threonine-protein kinase 24 has a certain effect on NSCLC. 33 Serine/threonine-protein kinases are related to inflammation regulation 41 ; this information can be used to evaluate drug efficacy.…”

Section: Discussionmentioning

confidence: 99%

The Activity, Composition and Molecular Mechanism of Bothriospermum zeylanicum (Hornem.) Fisch. Et Mey Alleviation of Nonsmall Cell Lung Cancer

Zhao,

Ge,

Liao

et al. 2024

Natural Product Communications

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Objective: To study the effect of the ethyl acetate extract of Bothriospermum zeylanicum (Hornem.) Fisch., the active ingredients and mechanism of Et Mey (EAF) in nonsmall cell lung cancer (NSCLC) were explored. Methods: 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay was used to measure the effect of EAF on the proliferation of A549, HL-60, SMMC-7721, MDA-MB-231, and SW480 tumor cells. The components were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS), and the blood components were retrieved from the constituents absorbed into the blood and metabolites of traditional Chinese medicine (DCABM-TCM) database. The mechanism was determined by network pharmacology and verified by molecular docking. Results: The IC50 values for the proliferation of tumor cell strains were 41.13, 56.72, 36.69, 48.63, and 44.48 μg/mL, respectively. A concentration of 100 μg/mL had the strongest inhibitory effect on A549 cells. A total of 33 chemical components were identified by LC-MS, 7 of which have been reported to have certain anti-NSCLC effects, and a total of 6 blood components were identified using the DCABM-TCM database. Network pharmacology analysis revealed that anti-NSCLC activity mainly involves EGFR tyrosine kinase inhibitor resistance, the PI3K-Akt signaling pathway, the AGE-RAGE signaling pathway in diabetic complications, the HIF-1 signaling pathway and the VEGF signaling pathway. The molecular docking results verified that hesperetin, luteolin, and pinocembrin bind well to the AKT1, IL6, EGFR, BCL2, and CASP3 target proteins. Conclusion: The ethyl acetate fraction of B. zeylanicum (Hornem.) Fisch. Et Mey had obvious ant-non NSCLC activity, which may be related to resistance to EGFR tyrosine kinase inhibitors and the PI3K-Akt signaling pathway in diabetic complications, and its active ingredients may be hesperetin, luteolin, and pinocembrin.

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“…To our knowledge, there are no reports linking Lactobacillus johnsonii to bone density in humans or rodents. However, a recent study demonstrates that treating mice with a multi-herbal supplement containing panax ginseng (BaWeiBaiDuSan) increases the abundance of Lactobacillus johsonii and alleviates polymicrobial sepsis-induced liver injury in mice ( Fan et al, 2023 ). In addition, treatment with Lactobacillus johnsonii also prevents polymicrobial sepsis-induced liver injury and this was associated with an increase in serum IL-10 suggesting that L. johnsonii may have an overall anti-inflammatory effect.…”

Section: Discussionmentioning

confidence: 99%

Korean red ginseng extract prevents bone loss in an oral model of glucocorticoid induced osteoporosis in mice

Chargo,

Kang,

Das

et al. 2024

Front. Pharmacol.

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The gut microbiota and barrier function play important roles in bone health. We previously demonstrated that chronic glucocorticoid (GC)-induced bone loss in mice is associated with significant shifts in gut microbiota composition and impaired gut barrier function. Korean Red Ginseng (KRG, Panax Ginseng Meyer, Araliaceae) extract has been shown to prevent glucocorticoid-induced osteoporosis (GIO) in a subcutaneous pellet model in mice, but its effect on gut microbiota and barrier function in this context is not known. The overall goal of this study was to test the effect of KRG extract in a clinically relevant, oral model of GIO and further investigate its role in modulating the gut-bone axis. Growing male mice (CD-1, 8 weeks) were treated with 75 μg/mL corticosterone (∼9 mg/kg/day) or 0.4% ethanol vehicle in the drinking water for 4 weeks. During this 4-week period, mice were treated daily with 500 mg/kg/day KRG extract dissolved in sterile water or an equal amount of sterile water via oral gastric gavage. After 4 weeks of treatment, we assessed bone volume, microbiota composition, gut barrier integrity, and immune cells in the bone marrow (BM) and mesenteric lymph nodes (MLNs). 4 weeks of oral GC treatment caused significant distal femur trabecular bone loss, and this was associated with changes in gut microbiota composition, impaired gut barrier function and altered immune cell composition. Importantly, KRG extract prevented distal femur trabecular bone loss and caused significant alterations in gut microbiota composition but had only modest effects on gut barrier function and immune cell populations. Taken together, these results demonstrate that KRG extract significantly modulates the gut microbiota-bone axis and prevents glucocorticoid-induced bone loss in mice.

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Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice

Cited by 28 publications

References 57 publications

Fasting mimicking diet extends lifespan and improves intestinal and cognitive health

Fasting mimicking diet extends lifespan and improves intestinal and cognitive health

The Activity, Composition and Molecular Mechanism of Bothriospermum zeylanicum (Hornem.) Fisch. Et Mey Alleviation of Nonsmall Cell Lung Cancer

Korean red ginseng extract prevents bone loss in an oral model of glucocorticoid induced osteoporosis in mice

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