Herbal gums and mucilage as excipients for Pharmaceutical Products

Sharma, Dev Raj; Sharma, Amit; Kaundal, Ankaj; Kumar, Prem

doi:10.5958/0975-4385.2016.00026.1

Cited by 9 publications

(10 citation statements)

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“…Angle of repose declare the penury glide property which displays stem of Manilkara hexandra gum (MHG) was cohesive [27]. The gum of Manilkara hexandra gum (MHG) is less viscous due to the complex nature of polysaccharide and monosaccharide derivatives found in it [28]. Bulk density (g/ml) 0.7591±0.00001 2.…”

Section: Flow Property Of the Gummentioning

confidence: 99%

Characterization and Hypoglycemic Study of Isolated Natural Polymer From the Stem of Manilkara Hexandra (Roxb.) Dubard

Monisha¹,

Vimala²

2019

Int J App Pharm

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Objective: In the present study, the isolated natural polymer from the stem of Manilkara hexandra and their physiochemical parameters were investigated. It is further involved in hypoglycemic studies. Methods: The gum exudates were screened for phytochemicals, physicochemically analyzed for solubility, pH, total ash, moisture content, acid insoluble ash, water soluble ash, sulfated ash, flow property, and it is characterized by Fourier Transform Infrared analysis (FT-IR), Scanning Electron Microscope (SEM), X-ray diffraction analysis (XRD), Nuclear Magnetic Resonance (NMR) studies (13Carbon and 1Proton) and it was examined in vitro studies by hypoglycaemic activity. Results: The isolated gum extracted from the stem of Manilkara hexandra (Roxb.) Dubard ash values were found to be low. The gum is found to be hygroscopic in nature due to its high moisture content (0.9131±0.03). Fourier Transform Infrared (FT-IR) spectra show relevant functional groups for gum, which is further confirmed by resonance spectral studies. The X-ray diffraction (XRD) pattern shows that the gum is amorphous as well as crystalline in nature. Scanning Electron Microscope (SEM) image confirms that the gum particles have irregular size and shape. Sugar composition analysis by Thin Layer Chromatography indicated the presence of rhamnose, arabinose. The in vitro study of hypoglycemic activity shows the best report compared with the standard. The experimental evidence offers scope to use this natural polymer in the food and pharmaceutical industry. Conclusion: The isolated natural polymer shows good result in hypoglycemic studies compared with standard.

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Section: Flow Property Of the Gummentioning

confidence: 99%

Characterization and Hypoglycemic Study of Isolated Natural Polymer From the Stem of Manilkara Hexandra (Roxb.) Dubard

Monisha¹,

Vimala²

2019

Int J App Pharm

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“…Gum has its composition significant amounts of calcium, potassium and magnesium salts present in uronic acids (HIRST; JONES, 1958). The mucilage is made up of ester groups of sulfuric acid (ASPINALL, 1970 SHARMA et al, 2016). Most gums dissolve in water and are, therefore, hydrophilic.…”

Section: Chemical Composition Of Gum and Mucilagementioning

confidence: 99%

“…Studies have reported that mango gum has antiviral (SILVA; DUARTE; VIEIRA FILHO, 2014), anthelmintic (MARIMUTHU, 2001; MUTHUKUMARAN, 2017), and antibacterial properties (BAYONA, 2016;SHARMA et al, 2016). This property is due to the presence of alkyl groups of the aromatic compound.…”

Section: Introductionmentioning

confidence: 99%

Potential Use of Mango Gum (Mangifera Indica) in Pharmacological Systems

Silveira¹,

Glória²,

Barbosa³

et al. 2019

PTQ

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The possibility of using natural or modified polymers to formulate drug-containing nanocapsules is a pharmaceutical option for cases in which an increase in the half-life of medications in the body and a decrease in side effects is required, and may also be used for better pharmacological targeting of the site. Related to low production costs with these characteristics and renewable availability. Gums and mucilages have been studied for use in natural alternative drug delivery systems. The gum from the trunk of Mangifera indica has few studies aimed at this purpose, although it has shown promising results in previous studies. Characterization of the gum formation pathways are explained, as well as their extraction and purification. The similarity of properties of Acacia gum widely used in tablet blends has been confirmed. Mangifera indica gum was also used for accelerated drug release. The versatility of this gum is associated with the presence of mucilage. Chemical modifications of the Mangifera indica gum and mixtures among other gums may be made to adapt their properties to the various forms of controlled drug release. Several isolated compounds with pharmaceutical properties are demonstrated. Physical chemical characteristics of several articles on this gum have been compiled. The techniques already used for the formation of nanocapsules through Mangifera indica gum are presented. Several studies have been reported specifically using Mangifera indica gum from the Mango trunk used as drug release. These studies justify a summary of the pharmaceutical properties for drug delivery already performed with this gum. Complementary studies for utilization and valorization of Mango cultivation are suggested.

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“…They could be used for treatment of musculoskeletal, urinary, respiratory, gastrointestinal, immunomodulation, and skin disorders through oral or topical forms (3). Mucilage compounds are also used in pharmaceutical industries as disintegrating, binding, gelling, and suspending agents or emulsion stabilizers (4).…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective effect of mucilage fraction from Solenostemma argel via cytoprotection and attenuation of oxidative stress, inflammation and apoptosis

El-Shiekh

Salama

Al-Mokaddem

et al. 2021

J Herbmed Pharmacol

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Introduction: Polysaccharides have numerous therapeutic values including immunity stimulation, angiotensin converting enzyme inhibition, wound healing, anti-diabetic and cytotoxic activities, in addition to their potent anti-oxidant properties. This work examined the gastroprotective and ulcer healing potential of mucilage fraction isolated from Solenostemma argel (Delile) Hayne (MFA) against ethanol-induced gastric ulcer in rats. Methods: Forty Sprague-Dawley rats were divided into five groups (n=8); normal control (I), ethanol control (II), 20 mg/kg Antodine pretreated rats (III), 100 mg/kg, and 200 mg/kg MFA pretreated rats, respectively (IV & V). All rats in groups II-V received single intragastric dose of ethanol (5 mL/kg) to induce gastric ulcer. Gastric mucosal injuries were assessed by stomach gross examination as well as histopathology, and immunohistochemistry of apoptotic markers. Also, several biochemical parameters including oxidative stress, proinflammatory cytokines, cytoprotective and cell proliferative biomarkers were measured. Results: High-performance liquid chromatography (HPLC) analysis of MFA revealed its composition of glucose, D-fucose and N-acetyl glucosamine as monosaccharaides, in addition to glucuronic and galacturonic acids. The data showed that MFA, 200 mg/kg had potent antioxidant, anti-inflammatory, cytoprotective, cell proliferative, and antiapoptotic activities which were better than Antodine. Conclusion: This study revealed that MFA had significant gastroprotective effects against ethanol-induced gastric injuries and could be a promising adjuvant therapy for ulcer treatment.

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Herbal gums and mucilage as excipients for Pharmaceutical Products

Cited by 9 publications

References 0 publications

Characterization and Hypoglycemic Study of Isolated Natural Polymer From the Stem of Manilkara Hexandra (Roxb.) Dubard

Characterization and Hypoglycemic Study of Isolated Natural Polymer From the Stem of Manilkara Hexandra (Roxb.) Dubard

Potential Use of Mango Gum (Mangifera Indica) in Pharmacological Systems

Gastroprotective effect of mucilage fraction from Solenostemma argel via cytoprotection and attenuation of oxidative stress, inflammation and apoptosis

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