Herbal medicine for psoriasis and their molecular targets: A systematic review

Yosita, Kasemnitichok; Wanna, Chaijaroenkul; Kesara, Na-Bangchan

doi:10.5897/ajpp2022.5292

Cited by 3 publications

(1 citation statement)

References 150 publications

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“…https://www.indjst.org/ Cycloartenol glycosides extracted from the root regions of Cimicifuga simplex have been utilized effectively as an antiinflammatory drug in studies. Their anti-inflammatory properties were shown in vitro by LPS-stimulated IL-23, IL-6, and TNFgene production in RAW cells using the Q-PCR technique (25) . The current study's findings were similarly consistent with the results.…”

Section: Discussionmentioning

confidence: 99%

In-Silico and Pharmacokinetic Studies of Bioactive Constituents from Green Marine Macro Algae Valoniopsis pachynema Against Psoriasis

Bhuvaneshwari,

Chitra,

Vidya

et al. 2023

IJST

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Objectives: To validate the pharmacokinetic effects of the bioactive constituents present in green marine algae Valoniopsis pachynema for treating Psoriasis by in silco methods. Methods: The green marine macroalga was collected from the coastal areas of Ramanathapuram, Tamil Nadu and it was confirmed as Valoniopsis pachynema by the CSIR-Central Marine Algal Research Station, Ramanathapuram. The GC-MS analysis of the algal extract revealed the presence of 7 different functional compounds and these ligands molecules were used for molecular docking studies with TNF-α, which is majorly involved in causing Psoriasis. The ADME Predictions of 7 compounds were computed by SwissADME and PreADMET tools. The physico-chemical properties and druglikeness predictions of the compounds 1-7 were analysed by Molinspiration. The Molecular Docking scores and the residual amino acid interactions of 7 compounds against crystal structure of TNF-α (2AZ5) binding domain were analysed by Autodock Vina. Findings : The potential functional compounds present in the algal extract were found to be Cycloartenol (CAL), Eicosane (ESN), Phytol (PTL), Cis-13 Eicosenoic acid (CEA), Octadecanoic acid (ODA), Squalene (SQL) and Neophytadiene (NPN). The pharmacokinetic properties and docking studies of all 7 different ligands revealed Cycloartenol as the effective ligand having inhibitor constant 3.05µM and binding energy of -7.52 kcal/mol against TNF-α and it was found to interact with the amino acids ILE 136 and PRO 139 present in the active site domain of the protein. According to the in silico studies, the active component (Cycloartenol (CAL) in Valoniopsis pachynema reduces the amount of tumour necrosis factor which is produced in chronic skin inflammation. Thus, the seaweed metabolites were found to be the promising candidates https://www.indjst.org/ 4339

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Section: Discussionmentioning

confidence: 99%

In-Silico and Pharmacokinetic Studies of Bioactive Constituents from Green Marine Macro Algae Valoniopsis pachynema Against Psoriasis

Bhuvaneshwari,

Chitra,

Vidya

et al. 2023

IJST

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GC-MS analysis and the effect of topical application of essential oils of Pinus canariensis C.Sm., Cupressus lusitanica Mill. and Cupressus arizonica Greene aerial parts in Imiquimod–Induced Psoriasis in Mice

Kamal

Sabry

El-Halawany

et al. 2024

Journal of Ethnopharmacology

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Role of Apoptotic-targeted Phytoconstitutent-loaded Antipsoriatic Nanobiocomposites

Patel

Srivastava²,

Panchawat

2024

NANOTEC

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Psoriasis is an inflammatory and proliferative autoimmune dermatological disorder. It is a skin ailment that is defined by particular, drab-red or peach-pink stiff areas with silvery scales patches. Other typical characteristics include the proliferation of epidermal layer, aberrant keratinization, hyperkeratosis, increased micro capillary vascularization, and infiltration of inflammatory mediator loaded cells. Conventional pharmacotherapies currently available can only provide minor advantages. Nanomedicines based on nanotechnology can potentially improve the efficacy and safety of psoriasis medications. Apoptosis plays an important pathogenetic role in many chronic inflammatory diseases, including those of dermatological interest, in particular, regarding psoriasis. In this regard, treatments with antioxidant properties could be appropriate therapeutic options. We reviewed the available studies on the efficacy of antiapoptotic therapies in psoriasis. We'll look at phytochemicals in this review, which are natural components found in plants with antiapoptotic activity that are frequently used to treat psoriasis. For improved topical treatment, we also take into consideration the advantages of loading phytoconstituents as medicines into lipid based nanocarriers. The utilization of herbal nanomedicines in psoriasis, as well as nano delivery carrier system for phytoconstituents with improved therapeutic profiles and decreased toxicity, are the subjects of this review. The study's purpose is to find more effective herbal nanomedicines for treating psoriasis. In the treatment of psoriasis, phytoconstituents that have shown antipsoriatic potential in recent years, as well as phytoconstituents loaded based nanomedicines, have a lot of promising roles to be explored. Furthermore, very few patents have been found in the field of nanotechnology utilizing lipid-based nanocarrier system for the treatment of psoriasis. Therefore, this review greatly compels the researcher to validate the process development of lipid-based drug delivery system for the patentability of the product. This should be in a view of shifting in the applicability of the drug delivery system for general public health as a potential treatment option in psoriasis.

show abstract

Herbal medicine for psoriasis and their molecular targets: A systematic review

Cited by 3 publications

References 150 publications

In-Silico and Pharmacokinetic Studies of Bioactive Constituents from Green Marine Macro Algae Valoniopsis pachynema Against Psoriasis

In-Silico and Pharmacokinetic Studies of Bioactive Constituents from Green Marine Macro Algae Valoniopsis pachynema Against Psoriasis

GC-MS analysis and the effect of topical application of essential oils of Pinus canariensis C.Sm., Cupressus lusitanica Mill. and Cupressus arizonica Greene aerial parts in Imiquimod–Induced Psoriasis in Mice

Role of Apoptotic-targeted Phytoconstitutent-loaded Antipsoriatic Nanobiocomposites

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