Herbal Medicines for Rhinosinusitis: A Systematic Review and Network Meta-analysis

Hoang, Minh P; Seresirikachorn, Kachorn; Chitsuthipakorn, Wirach; Snidvongs, Kornkiat

doi:10.1007/s11882-022-01060-z

Cited by 5 publications

(3 citation statements)

References 66 publications

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“…A recent meta-analysis investigating the role of herbal medicines in rhinosinusitis supports the findings of this survey, as cineole was found to be among the most effective treatments for acute viral rhinosinusitis [18]. Similarly, another systematic review confirmed positive results using cineole in rhinosinusitis [19].…”

Section: Discussionsupporting

confidence: 77%

Rhinosinusitis Treatment with Cineole: Patient-Reported Quality of Life Improvements from a Non-Interventional, Pharmacy-Based Survey

Werkhäuser,

Pieper-Fürst,

Sahin

et al. 2023

Medicines

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Background: Rhinosinusitis is commonly treated with decongestants, analgesics, and local corticosteroids. Phytotherapeutics are also utilised for symptomatic relief, including cineole, the main component of eucalyptus oil. Methods: The current non-interventional, anonymised survey investigated quality of life in participants with rhinosinusitis (with or without additional symptoms of bronchitis) via the German version of a validated quality of life questionnaire (RhinoQol). Overall, 310 subjects administered a cineole preparation (Sinolpan) and 40 subjects applying nasal decongestant were recruited in German pharmacies. Results: Significant improvements in frequency (64.0%), bothersomeness (52.1%), and impact (53.9%) of rhinosinusitis symptoms were reported upon treatment with cineole over a mean treatment period of seven days (p < 0.001 each). The overall treatment efficacy of cineole was evaluated as good or very good by 90.0% of the participants, and the quality of life during work or leisure time improved upon treatment. Six (non-serious) possibly related side effects were reported in four participants who were administered cineole. The tolerability of the treatment was assessed as good or very good by 93.9% of the participants. Conclusions: Cineole can be considered as a safe and well-tolerated rhinosinusitis treatment conferring a clear improvement in quality of life outcomes.

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Section: Discussionsupporting

confidence: 77%

Rhinosinusitis Treatment with Cineole: Patient-Reported Quality of Life Improvements from a Non-Interventional, Pharmacy-Based Survey

Werkhäuser,

Pieper-Fürst,

Sahin

et al. 2023

Medicines

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“…A recent systematic review with network meta-analysis, showed very little solid evidence of herbal medicine versus placebo for common cold, with only P. sidoides and Andrographis paniculata showing a reliable decrease of symptoms. Better results were found for herbal medicine versus placebo concerning health related quality of life (HRQoL) (in particular Spicae aetheroleum ) and for symptoms (Cineole and P. sidoides ) ( Hoang et al, 2023 ). A further systematic review reported on the efficacy of P. sidoides (liquid and tablet preparation) for the treatment of acute bronchitis, showing a positive results with, however, low evidence quality ( Timmer et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Current state of research on the clinical benefits of herbal medicines for non-life-threatening ailments

Salm,

Rutz,

van den Akker

et al. 2023

Front. Pharmacol.

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Herbal medicines are becoming increasingly popular among patients because they are well tolerated and do not exert severe side effects. Nevertheless, they receive little consideration in therapeutic settings. The present article reviews the current state of research on the clinical benefits of herbal medicines on five indication groups, psychosomatic disorders, gynecological complaints, gastrointestinal disorders, urinary and upper respiratory tract infections. The study search was based on the database PubMed and concentrated on herbal medicines legally approved in Europe. After applying defined inclusion and exclusion criteria, 141 articles were selected: 59 for psychosomatic disorders (100% randomized controlled trials; RCTs), 20 for gynecological complaints (56% RCTs), 19 for gastrointestinal disorders (68% RCTs), 16 for urinary tract infections (UTI, 63% RCTs) and 24 for upper respiratory tract infections (URTI) (79% RCTs). For the majority of the studies, therapeutic benefits were evaluated by patient reported outcome measures (PROs). For psychosomatic disorders, gynecological complaints and URTI more than 80% of the study outcomes were positive, whereas the clinical benefit of herbal medicines for the treatment of UTI and gastrointestinal disorders was lower with 55%. The critical appraisal of the articles shows that there is a lack of high-quality studies and, with regard to gastrointestinal disorders, the clinical benefits of herbal medicines as a stand-alone form of therapy are unclear. According to the current state of knowledge, scientific evidence has still to be improved to allow integration of herbal medicines into guidelines and standard treatment regimens for the indications reviewed here. In addition to clinical data, real world data and outcome measures can add significant value to pave the way for herbal medicines into future therapeutic applications.

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“…Dessa forma, as plantas medicinais e fitoterápicos têm potenciais desconhecidos, mas imagináveis. Por exemplo, Myrtol ® , BNO-101 e Cyclamen europaeum, relatados nas revisões desta pesquisas são um produtos fitoterápico, utilizados para o tratamento da rinossinusite aguda e crônica, possui vantagem clínica em comparação com medicamentos convencionais por ser uma alternativa à antibioticoterapia, evitando o desenvolvimento de resistência e efeitos colaterais (HOANG et al, 2023;HOSSAIN et al, 2023;PAPAROUPA;GILLIS-SEN, 2016). Além desses fitoterápicos, outra planta medicinal utilizada para o tratamento de doenças é a Cannabis sativa, que vem sendo estudada para o tratamento de esclerose múltipla, uma doença crônica, inflamatória e autoimune que causam muitas dores aos enfermos, pois possui diversos efeitos farmacológicos, como anestésico e antiemético, mesmo apresentando propriedades psicoativas (RABELO, 2019).…”

Section: Implicações Práticas Para a Prescrição De Plantas Medicinais...unclassified

Efetividade Clínica Das Plantas Medicinais E Fitoterapia Direcionadas Às Doenças Crônicas

Ferreira¹,

Rodrigues²

2023

A Efetividade Clínica Das Plantas Medicinais Brasileiras

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Os autores desta obra assumem publicamente a responsabilidade pelo seu conteúdo, garantindo que o mesmo é de autoria própria, original e livre de plágio acadêmico. Os autores declaram, ainda, que o conteúdo não infringe nenhum direito de propriedade intelectual de terceiros e que não há nenhuma irregularidade que comprometa a integridade da obra. Os autores assumem integral responsabilidade diante de terceiros, quer de natureza moral ou patrimonial, em razão do conteúdo desta obra. Esta declaração tem por objetivo garantir a transparência e a ética na produção e divulgação do artigo. Cumpre esclarecer que o conteúdo do artigo é de responsabilidade exclusiva dos autores, não refletindo, necessariamente, a opinião da editora ou do conselho editorial.

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Herbal Medicines for Rhinosinusitis: A Systematic Review and Network Meta-analysis

Cited by 5 publications

References 66 publications

Rhinosinusitis Treatment with Cineole: Patient-Reported Quality of Life Improvements from a Non-Interventional, Pharmacy-Based Survey

Rhinosinusitis Treatment with Cineole: Patient-Reported Quality of Life Improvements from a Non-Interventional, Pharmacy-Based Survey

Current state of research on the clinical benefits of herbal medicines for non-life-threatening ailments

Efetividade Clínica Das Plantas Medicinais E Fitoterapia Direcionadas Às Doenças Crônicas

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