Herbal, Nutritional, and Traditional Remedies for Giardiasis

Bhattacharyya, Samrat

doi:10.1002/9781119617143.ch4

Cited by 2 publications

(4 citation statements)

References 95 publications

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“…While there is limited research specifically focused on the role of minerals in the treatment of giardiasis, some studies have indicated that minerals like Zinc, Copper, Selenium, and Iron may possess potential anti-giardial properties. [35,36] Zinc was reported as an essential mineral that plays a crucial role in immune function. It has been found to have inhibitory effects on Giardia lamblia growth and attachment to the intestinal wall.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, micro and macro minerals are essential nutrients required by the body in small and large quantities, for various physiological functions. While there is limited research specifically focused on the role of minerals in the treatment of giardiasis, some studies have indicated that minerals like Zinc, Copper, Selenium, and Iron may possess potential anti‐giardial properties [35,36] . Zinc was reported as an essential mineral that plays a crucial role in immune function.…”

Section: Discussionmentioning

confidence: 99%

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Nutritional Value and in vitro Antigiardial Activity of Anise (Pimpinella anisum L.) Seeds

Alrasheid,

Kabbashi,

Ali

et al. 2024

Chemistry & Biodiversity

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The present study focused on evaluating the proximate analysis, mineral composition, and in vitro anti‐giardial activity of Pimpinella anisum seed extracts, which are aromatic plants with a long history of usage in folk and conventional medicine, as well as pharmaceutical manufacturing. Standard methods were used to determine the proximate analysis of the powdered plant sample, including dry matter, ash, fat, protein, fiber, and carbohydrates. The mineral contents of Pimpinella anisum seed were analyzed using Inductively Coupled Plasma Mass Spectrometry (ICP‐MS), revealing that the plant has a high fiber content (42.62%) followed by carbohydrates (38.79%). The seeds were also found to be a rich source of minerals, with notable amounts of Rubidium, Magnesium, and Calcium. The extracts showed a high mortality percentage compared to Metronidazole, with the chloroform extract exhibiting higher anti‐giardial activity (78.71%) than the ethanolic extract (75.29%) at a concentration of 500 ppm. These findings support the traditional use of Anise in treating gastrointestinal issues and as a natural supplement. Further studies are needed to isolate the active ingredients and understand their mechanism of action.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nutritional Value and in vitro Antigiardial Activity of Anise (Pimpinella anisum L.) Seeds

Alrasheid,

Kabbashi,

Ali

et al. 2024

Chemistry & Biodiversity

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“…Metronidazole (MTZ) is the most used drug to address Giardiasis . However, emerging studies are showing an increasingly developing Giardia resistance to MTZ [ 71 , 72 ]. In this context, nutritional sources have shown promise in mitigating parasite removal.…”

Section: Nutritional Interventionsmentioning

confidence: 99%

“…Although supplementation of micronutrients such as zinc have been suggested to control parasitic activity in gut [ 72 ], it has been shown that in the infant gut, supplementation of micronutrients such as iron and vitamins (A, C, D, folate), but without zinc, decrease gut microbiome diversity and aid the growth of protozoal parasites, such as Entamoeba [ 77 ]. Therefore, it is important to ascertain the impact of certain nutritional interventions.…”

Section: Nutritional Interventionsmentioning

confidence: 99%

Intelligent Biological Networks: Improving Anti-Microbial Resistance Resilience through Nutritional Interventions to Understand Protozoal Gut Infections

2023

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Enteric protozoan pathogenic infections significantly contribute to the global burden of gastrointestinal illnesses. Their occurrence is considerable within remote and indigenous communities and regions due to reduced access to clean water and adequate sanitation. The robustness of these pathogens leads to a requirement of harsh treatment methods, such as medicinal drugs or antibiotics. However, in addition to protozoal infection itself, these treatments impact the gut microbiome and create dysbiosis. This often leads to opportunistic pathogen invasion, anti-microbial resistance, or functional gastrointestinal disorders, such as irritable bowel syndrome. Moreover, these impacts do not remain confined to the gut and are reflected across the gut–brain, gut–liver, and gut–lung axes, among others. Therefore, apart from medicinal treatment, nutritional supplementation is also a key aspect of providing recovery from this dysbiosis. Future proteins, prebiotics, probiotics, synbiotics, and food formulations offer a good solution to remedy this dysbiosis. Furthermore, nutritional supplementation also helps to build resilience against opportunistic pathogens and potential future infections and disorders that may arise due to the dysbiosis. Systems biology techniques have shown to be highly effective tools to understand the biochemistry of these processes. Systems biology techniques characterize the fundamental host–pathogen interaction biochemical pathways at various infection and recovery stages. This same mechanism also allows the impact of the abovementioned treatment methods of gut microbiome remediation to be tracked. This manuscript discusses system biology approaches, analytical techniques, and interaction and association networks, to understand (1) infection mechanisms and current global status; (2) cross-organ impacts of dysbiosis, particularly within the gut–liver and gut–lung axes; and (3) nutritional interventions. This study highlights the impact of anti-microbial resistance and multi-drug resistance from the perspective of protozoal infections. It also highlights the role of nutritional interventions to add resilience against the chronic problems caused by these phenomena.

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Herbal, Nutritional, and Traditional Remedies for Giardiasis

Cited by 2 publications

References 95 publications

Nutritional Value and in vitro Antigiardial Activity of Anise (Pimpinella anisum L.) Seeds

Nutritional Value and in vitro Antigiardial Activity of Anise (Pimpinella anisum L.) Seeds

Intelligent Biological Networks: Improving Anti-Microbial Resistance Resilience through Nutritional Interventions to Understand Protozoal Gut Infections

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